This document summarizes a numerical study that simulated natural convection heat transfer in a cubical cavity filled with nanofluids. The cavity is heated by a partition maintained at a hot temperature, while the right and left walls are kept at a cold temperature and the rest are adiabatic. Results show that increasing the Rayleigh number, volume fraction of nanoparticles, and size of the heating partition all improve heat transfer. Copper-based nanofluids provided the best thermal transfer. The study analyzes temperature, velocity and heat transfer to understand how nanofluids affect natural convection in 3D enclosures.