This document discusses single complete dentures opposing natural teeth. It defines a single complete denture as a prosthesis that replaces all lost teeth in one arch. Challenges include managing high occlusal forces from natural teeth and accommodating the occlusal form of remaining teeth. Diagnosis requires evaluating support, interarch relationships, and preserving remaining structures. Various combinations are described, like a maxillary complete denture opposing natural mandibular teeth. Methods to achieve balanced occlusion include functional jaw movements to record occlusal schemes or articulator-based equilibration.