![(feinscore@gmail.com – support appendix to resume, papers technical reports presentations patents projects dissertation pg.6)
REPRESENTATIVE PUBLICATIONS out of 9, ABSTRACTS out of 8, (as Post-doc / Graduate Student for or at UAZ / UNM)
1
Inscore, F., Knottenbelt, S., Rubie, N., Joshi, H., Kirk, M., Enemark, J., “Understanding the origin of metal-sulfur vibrations in
an oxo molybdenum dithiolene complex: relevance to sulfite oxidase”, Inorg. Chem., 45, 967, 2006
2
Joshi, H.K., Cooney, J.J.A., Inscore, F.E., Gruhn, N.E., Lichtenberger, D.L., Enemark, J.H. “Investigation of metal-dithiolate
fold angle effects: Implications for molybdenum and tungsten Enzymes”, Proc. Nat. Acad. Sci., 100, 3719-3724, 2003
3
Wang, X.B., Inscore, F.E., Yang, X., Cooney, J.J.A., Enemark, J.H., Wang, L.S., “Probing the electronic structure [MoOS4]-
centers using anionic photoelectron spectroscopy”, J. Am. Chem. Soc., 124, 10182, 2002
4
Inscore, F.E., Joshi, H., McElhaney, A., Enemark, J.H., “Remote ligand substituent effects on the properties of Oxo-Mo(V)
centers with a single ene-1,2-dithiolate ligand”, Inorg. Chim. Acta., 331, 246-256 (invited paper special issue Geof Sykes) 2002
5
Hemant Joshi, Frank E. Inscore, Julien Schirlin, Ish Dhawan, Michael Carducci, Tonja Bill, John Enemark, “Six-coordinate
molybdenum nitrosyls with a single ene-1,2-dithiolate ligand”, Inorg. Chim. Acta., 337, 275-286 (invited paper Wieghardt) 2002
6
McElhaney, A.E., Inscore, F.E., Schirlin, J.T., Enemark, J.H., “Electron transfer studies of dithiolate complexes: effects of
ligand variation and metal substitution”, Inorg. Chim. Acta., 341, 85-90 (invited paper Kenneth Raymond) 2002
7
Inscore, F., Hill, J., Young, C., Enemark, J., Kirk, M. “Electronic structure contributions to reduction potentials and oxygen
atom transfer reactivity in oxo-Mo and oxo-W dithiolates: Insight into tungsten and molybdenum pyranopterin enzymatic
reactivity differences”, Abstract - Invited speaker / paper at Gordon Conference, Ventura, CA, 2001
8
Inscore, F.E., McNaughton, R., Westcott, B.L., Helton, M., Jones, R., Dhawan, I.K., Enemark, J.H., Kirk, M.L. “Spectroscopic
evidence for a unique bonding interaction in oxo-molybdenum dithiolate complexes: Implications for sigma- electron-transfer
pathways in the pyranopterin dithiolene centers of enzymes”, Inorg. Chem., 38, 1401-1410, 1999
9
Jones, R.M., Inscore, F.E., Hille, R., Kirk, M.L., “Freeze-quench magnetic circular dichroism spectroscopic study of the very
rapid intermediate in xanthine oxidase” Inorganic Chemistry, 38, 4963, 1999
PATENTS (at or for RTA)
“SERS method and apparatus for rapid extraction and analysis of drugs in saliva” U.S. Patent Number 7393691, July 2008
“SERS method rapid pharmacokinetic analysis drugs in saliva” U.S. Patent Number 7393692, July 2008
“Method effecting rapid release of signature chemical from bacterial endospores, and for Detection thereof” #7713914B2, 2010
“Method & apparatus for 2 step SERS Assays” (Dec 2011); +1 in progress (2013); +5 assists awarded to RTA (2003 - 2015)
REPRESENTATIVE PROGRAMS PROJECTS CONTRACTS COMPLETED (out of 50, hands-on directed / managed at RTA)
• Achieved on-site analysis of bulk/clinical/forensic drug samples by Raman & SERS (UK Home Office, NIH, NSF)
• Constructed Raman/NIR/SER databases to identify pharmaceuticals, counterfeit drugs & quantify API (UK, Infratrac, USPC)
• Rapid identification quantification of chemotherapy drugs, metabolites in saliva (Yale Medical School, NIH)
• Accomplished real-time urine analysis to monitor astronaut bone-loss and drug efficacy in space (NASA)
• Monitored drug synthesis in microreactors & process lines with NeSSI fluidic interface (Parker-Hannifin, NSF)
• Analyzed biofilms/bacteria, proprietary anti-tooth decay agents in oral cavity by Raman/SERS/chemometrics (Colgate)
• Introduced new microplate sensors, drug chemical explosive biological Raman & SERS-based detection platforms (DigiLab)
• Initiated feasibility study with sales of Raman & SERS analyzers for drugs, chemical agents, explosives (Swedish DoD)
• Rapid identification of blood, urine, saliva toxins / drugs & bacterial infections with SERS/LSS system (Harvard, NSF)
• Derived multivariate chemometric Raman/NIR methods for jet , diesel & gasoline fuel analysis (USMC, Navy, Army, DoD)
• Proposed & tested feedback controls to monitor biomass conversions; catalyst/enzyme; biofuels; by Raman (UConn, DOE)
• Evaluated IR, and performed Raman and SERS chemometric analysis for embryo viability assessment (Viagen, NSF)
• Tested and evaluated real-time anthrax & hoax material Raman detectors, spectral libraries, chemometrics (NSF, DoD)
• Developed label-free capture assay for category A B bioagents / clinical pathogens in air water food (DARPA NSF INESCO)
• Provided novel food analyzer & methods for measuring food-borne pathogens in on food matrices (Kraft Foods, NSF)
• Field-usable analyzer measuring pesticide residues, chemical agents, organic pollutants in food and water (USDA, EPA)
• Supervised lab-on-chip, microchip development to detect biochemical proof-of-life signatures from soil (JPL, NASA, ASTID)
• Developed chem-bio warfare agent sensors; capillaries, microplates, disks, slides, tubing, vials (ECBC, U.S. Army, URI)
• Benchmarked hand-held Raman analyzer for non-contact identification of chemicals, CAIS & hazardous agents (CBD)
• Performed Raman & SERS feasibility contracts (e.g. NY Museum of Art, Miami Medical School, RJ Reynolds, Monsanto)
PUBLISHED Ph.D. DISSERTATION (at UNM)
“Electronic Structure Studies of Mo- and W-dithiolate Complexes: Electronic Structure Contributions to Reactivity in
Pyranopterin Molybdenum and Tungsten Enzymes”, PhD / Doctor of Philosophy / Chemistry, conferred on May 5, 2000
Doctorate Defense Committee:
Prof. M. Kirk, (Mentor/Advisor) Dept. Chem.; Bio-Inorganic Chemistry UNM
Prof. M. Ondrias, (Bell Lab Fellow) Dept. Chem.; Physical Chemistry UNM & Sandia National Laboratories (SNL) NM
Prof. E. Walters, (Regent Chair) Dept. Chem.; Physical Chemistry UNM
Prof. G. Kynner, (Emeritus, Brown Chair) Dept. Math & Computer Programming for Engineers; Applied Mathematics UNM
Prof. M. Hampden-Smith, Dept. Chem.; Inorganic Chemistry UNM & National Institute of Materials and Surfaces NM
Prof. F. Allen, (Dept Chair), Dept. Chem.; Analytical and Physical Chemistry UNM, founder of Chromex (bought out by Kaiser)
Dr. P.J. Hay, Theoretical Division; Computational Chemistry Group, Los Alamos National Laboratory (LANL) NM](https://image.slidesharecdn.com/1efeishortsupportappendix2015-150410170907-conversion-gate01/85/1e-fei-short-support-appendix-2015-2-320.jpg)
1e fei short support appendix 2015
- 1. (feinscore@gmail.com – support appendix to resume, papers technical reports presentations patents projects dissertation pg.5) REPRESENTATIVE PUBLICATIONS (out of 41, while at or for RTA) 1 S. Farquharson, C. Shende, W. Smith, H. Huang, F. Inscore, A. Sengupta, J. Sperry, T. Sickler, A. Prugh, J. Guicheteau “Selective detection of 1000 B. anthracis spores in 15min using peptide functionalized SERS assay” Analyst, 139, 6366, 2014 2 S. Farquharson, C. Shende, A. Gift, F. Inscore “Detection of Bacillus spores by surface-enhanced and Raman spectroscopy” In Bioterrorism, Stephen S. Morse, Ed., ISBN 978-953-307-636-2, 2012 3 Atanu Sengupta, Chetan Shende, Stuart Farquharson, and Frank Inscore, “Detection of Bacillus anthracis-Sterne Spores using peptide functionalized SERS-active substrates” International Journal of Spectroscopy, August 2012 4 Sengupta, A., C. Shende, H. Huang, S. Farquharson, F. Inscore “Rapid analysis of food borne pathogens by SERS; Listeria monocytogenes, Salmonella enterica and E. coli OH157” Proc. SPIE, 8369-19, 2012 5 Huang, H., C. Shende, A. Sengupta, F. Inscore, S. Farquharson “Evaluation of SERS substrates for chemical agent detection” Proc. SPIE, 8373-22, 2012 6 Hermes Huang, Chetan Shende, Atanu Sengupta, Frank Inscore, Carl Brouillette, Wayne Smith and Stuart Farquharson “SERS/Raman of Melamine /Other Chemicals Using 1550 nm (Retina-Safe) Laser” J. Raman Spectroscopy, 43, 01-705, 2012 7 Inscore, F., Shende, C., Sengupta, A., Huang, H., and Farquharson, S. “Detection of drugs of abuse in saliva by surface- enhanced Raman spectroscopy” Applied Spectroscopy, 65, 1004-1008, 2011 8 Farquharson, S., Shende, C., Sengupta, A., Huang, H., and Inscore, F. “Rapid detection and identification of overdose drugs in saliva by Surface-enhanced Raman scattering using fused gold colloids” Pharmaceutics, 3, 425-439, 2011 9 Inscore, F., Shende, C., Farquharson, S. “Astronaut health monitoring and urine analysis” NASA Medical tech briefs, 2010 10 Drapcho, D., Zlatkin, I., Inscore, F., Shende, C., Sengupta, A., Huang, H., Farquharson, S. “High throughput trace analysis using SERS-coated microtiter plates with a Raman plate reader” Spectroscopy (Special issue), 42-50, June 2010 11 Shende, C., Inscore, F., Sengupta, A., Stuart, J., and Farquharson, S. “Extraction and detection of part-per-billion Chlorpyrifos-methyl in orange juice in 12 minutes” Sensing and Instrumentation for Food Quality and Safety, 4, 101-107, 2010 12 Shende, C., Inscore, F., Sengupta, A., Farquharson, S. “Surface-enhanced Raman spectroscopy: Theory and application to the analysis of Chlorpyrifos in orange juice” Applications of Vibrational Spectroscopy in Food Science, Eds. ECY Li-Chan, PR Griffiths, JM Chalmers, John Wiley & Sons, West Sussex, UK, V1, 195-209, 2010 13 Farquharson, S., Gift, A., Shende, C., Inscore, F., Ordway, B., Farquharson, C., Murren, J. “Spectral measurements of 5- fluorouracil in saliva” Molecules, 13, 2608-2627, 2008 14 Farquharson, S., Inscore, F. “SERS-based analyzer for point and continuous water monitoring of chemical agents and their hydrolysis products” International Journal of High Speed Electronics and Systems, 101-111, 2007 15 Inscore, F., Shende, C., Maksymiuk, P., Farquharson, S. “Astronaut health monitoring” Proc. SPIE, 2006 16 Farquharson, S., Shende, C., Maksymiuk, P., Inscore, F. “Real-time control of small-scale reactor by Raman spectroscopy (a NeSSI application)” Proc. SPIE, 6371, 2006 17 Inscore, F., Farquharson, S., Smith, W. “Determination of jet and diesel fuel properties by chemometrics using a portable Raman analyzer” Proc. SPIE, 6371, 2006 18 S. Farquharson, F. Inscore, S. Christesen “Detecting chemical agents and their hydrolysis products in water” In K. Kneipp, M. Moskovits, H. Kneipp, Eds. Surface-Enhanced Raman Scattering - Physics and Applications (Springer-Verlag, Berlin) 2006 19 Inscore, F., Shende, C., Maksymiuk, P., Farquharson, S. “Ten-minute analysis of drugs and metabolites in saliva by surface-enhanced Raman spectroscopy” Proc. SPIE, 6007, 2005 20 Farquharson, S., Smith, W., Brouillette, C., Inscore, F. “Detecting Bacillus spores by Raman and surface-enhanced Raman spectroscopy” Spectroscopy, June supplement, 8-15, 2005 21 Farquharson, S., Gift, A., Maksymiuk, P., Inscore, F. “Surface-enhanced Raman spectra of VX and its hydrolysis products by surface-enhanced Raman spectroscopy” Applied Spectroscopy, 59, 654-660, 2005 22 Farquharson, S., Gift, A., Maksymiuk, P., Inscore, F. “Rapid dipicolinic acid extraction from Bacillus spores detected by surface-enhanced Raman spectroscopy” Applied Spectroscopy, 58, 351- 354, 2004 23 Farquharson, S., Gift, A., Maksymiuk, P., Inscore, F. “The pH dependence of methylphosphonic acid, dipicolinic acid, and cyanide by surface-enhanced Raman spectroscopy” Proc. SPIE, 5269, 117-125, 2003 REPRESENTATIVE TECHNICAL REPORTS (examples containing new papers submitted to federal govt. agencies for RTA) 1 Inscore, F., Farquharson, S. “SERS assay for Bacillus anthracis spores, Yersinia pestis & Francisella tularemia bacteria, Clostridium botulinum toxin A, and other bioagents (e.g. H1N1 virus, TB, SEB, SA, ECOH157, ST)” DARPA D21054 final 2013 2 Inscore, F., Farquharson, S. “Multiplexed chemical sensor for water security, NeSSI application” EPA EPD06084 2010/ 2009 3 Inscore, F., Farquharson, S. “Surface-enhanced Raman spectroscopic characterization of chemical warfare agent vesicant HD and related mono-sulfides” in U.S. Army DAAD13-02-C-0015, Joint Service Agent Water Monitor program final report 2006 REPRESENTATIVE PRESENTATIONS as INVITED SPEAKER (gave 50 talks for RTA, supported additional 50+ since 2003) 1 PITTCON 2013, Homeland security, analysis of drugs, explosives & chemical warfare agents; “B. anthracis spores, Y. pestis bacteria and C. botulinum A toxin detection by a field usable SERS assay”, F. Inscore, C. Shende, H. Huang, S. Farquharson 2 PITTCON 2012, Application of surface-enhanced Raman spectroscopy to real-world problems, arranged by S. Farquharson, “Detection of single-digit Bacillus anthracis spores in 15 minutes by SERS”, Frank Inscore, H. Huang, S. Farquharson 3 EAS 2011, Surface-enhanced Raman spectroscopy; application to real-world trace chemical & biological analysis, organized by Coblentz Society; “Drugs in Saliva”, Frank Inscore 4 SPIE 2006 “Determination of jet diesel fuel properties by chemometrics using portable Raman analyzer” F. Inscore W. Smith
- 2. (feinscore@gmail.com – support appendix to resume, papers technical reports presentations patents projects dissertation pg.6) REPRESENTATIVE PUBLICATIONS out of 9, ABSTRACTS out of 8, (as Post-doc / Graduate Student for or at UAZ / UNM) 1 Inscore, F., Knottenbelt, S., Rubie, N., Joshi, H., Kirk, M., Enemark, J., “Understanding the origin of metal-sulfur vibrations in an oxo molybdenum dithiolene complex: relevance to sulfite oxidase”, Inorg. Chem., 45, 967, 2006 2 Joshi, H.K., Cooney, J.J.A., Inscore, F.E., Gruhn, N.E., Lichtenberger, D.L., Enemark, J.H. “Investigation of metal-dithiolate fold angle effects: Implications for molybdenum and tungsten Enzymes”, Proc. Nat. Acad. Sci., 100, 3719-3724, 2003 3 Wang, X.B., Inscore, F.E., Yang, X., Cooney, J.J.A., Enemark, J.H., Wang, L.S., “Probing the electronic structure [MoOS4]- centers using anionic photoelectron spectroscopy”, J. Am. Chem. Soc., 124, 10182, 2002 4 Inscore, F.E., Joshi, H., McElhaney, A., Enemark, J.H., “Remote ligand substituent effects on the properties of Oxo-Mo(V) centers with a single ene-1,2-dithiolate ligand”, Inorg. Chim. Acta., 331, 246-256 (invited paper special issue Geof Sykes) 2002 5 Hemant Joshi, Frank E. Inscore, Julien Schirlin, Ish Dhawan, Michael Carducci, Tonja Bill, John Enemark, “Six-coordinate molybdenum nitrosyls with a single ene-1,2-dithiolate ligand”, Inorg. Chim. Acta., 337, 275-286 (invited paper Wieghardt) 2002 6 McElhaney, A.E., Inscore, F.E., Schirlin, J.T., Enemark, J.H., “Electron transfer studies of dithiolate complexes: effects of ligand variation and metal substitution”, Inorg. Chim. Acta., 341, 85-90 (invited paper Kenneth Raymond) 2002 7 Inscore, F., Hill, J., Young, C., Enemark, J., Kirk, M. “Electronic structure contributions to reduction potentials and oxygen atom transfer reactivity in oxo-Mo and oxo-W dithiolates: Insight into tungsten and molybdenum pyranopterin enzymatic reactivity differences”, Abstract - Invited speaker / paper at Gordon Conference, Ventura, CA, 2001 8 Inscore, F.E., McNaughton, R., Westcott, B.L., Helton, M., Jones, R., Dhawan, I.K., Enemark, J.H., Kirk, M.L. “Spectroscopic evidence for a unique bonding interaction in oxo-molybdenum dithiolate complexes: Implications for sigma- electron-transfer pathways in the pyranopterin dithiolene centers of enzymes”, Inorg. Chem., 38, 1401-1410, 1999 9 Jones, R.M., Inscore, F.E., Hille, R., Kirk, M.L., “Freeze-quench magnetic circular dichroism spectroscopic study of the very rapid intermediate in xanthine oxidase” Inorganic Chemistry, 38, 4963, 1999 PATENTS (at or for RTA) “SERS method and apparatus for rapid extraction and analysis of drugs in saliva” U.S. Patent Number 7393691, July 2008 “SERS method rapid pharmacokinetic analysis drugs in saliva” U.S. Patent Number 7393692, July 2008 “Method effecting rapid release of signature chemical from bacterial endospores, and for Detection thereof” #7713914B2, 2010 “Method & apparatus for 2 step SERS Assays” (Dec 2011); +1 in progress (2013); +5 assists awarded to RTA (2003 - 2015) REPRESENTATIVE PROGRAMS PROJECTS CONTRACTS COMPLETED (out of 50, hands-on directed / managed at RTA) • Achieved on-site analysis of bulk/clinical/forensic drug samples by Raman & SERS (UK Home Office, NIH, NSF) • Constructed Raman/NIR/SER databases to identify pharmaceuticals, counterfeit drugs & quantify API (UK, Infratrac, USPC) • Rapid identification quantification of chemotherapy drugs, metabolites in saliva (Yale Medical School, NIH) • Accomplished real-time urine analysis to monitor astronaut bone-loss and drug efficacy in space (NASA) • Monitored drug synthesis in microreactors & process lines with NeSSI fluidic interface (Parker-Hannifin, NSF) • Analyzed biofilms/bacteria, proprietary anti-tooth decay agents in oral cavity by Raman/SERS/chemometrics (Colgate) • Introduced new microplate sensors, drug chemical explosive biological Raman & SERS-based detection platforms (DigiLab) • Initiated feasibility study with sales of Raman & SERS analyzers for drugs, chemical agents, explosives (Swedish DoD) • Rapid identification of blood, urine, saliva toxins / drugs & bacterial infections with SERS/LSS system (Harvard, NSF) • Derived multivariate chemometric Raman/NIR methods for jet , diesel & gasoline fuel analysis (USMC, Navy, Army, DoD) • Proposed & tested feedback controls to monitor biomass conversions; catalyst/enzyme; biofuels; by Raman (UConn, DOE) • Evaluated IR, and performed Raman and SERS chemometric analysis for embryo viability assessment (Viagen, NSF) • Tested and evaluated real-time anthrax & hoax material Raman detectors, spectral libraries, chemometrics (NSF, DoD) • Developed label-free capture assay for category A B bioagents / clinical pathogens in air water food (DARPA NSF INESCO) • Provided novel food analyzer & methods for measuring food-borne pathogens in on food matrices (Kraft Foods, NSF) • Field-usable analyzer measuring pesticide residues, chemical agents, organic pollutants in food and water (USDA, EPA) • Supervised lab-on-chip, microchip development to detect biochemical proof-of-life signatures from soil (JPL, NASA, ASTID) • Developed chem-bio warfare agent sensors; capillaries, microplates, disks, slides, tubing, vials (ECBC, U.S. Army, URI) • Benchmarked hand-held Raman analyzer for non-contact identification of chemicals, CAIS & hazardous agents (CBD) • Performed Raman & SERS feasibility contracts (e.g. NY Museum of Art, Miami Medical School, RJ Reynolds, Monsanto) PUBLISHED Ph.D. DISSERTATION (at UNM) “Electronic Structure Studies of Mo- and W-dithiolate Complexes: Electronic Structure Contributions to Reactivity in Pyranopterin Molybdenum and Tungsten Enzymes”, PhD / Doctor of Philosophy / Chemistry, conferred on May 5, 2000 Doctorate Defense Committee: Prof. M. Kirk, (Mentor/Advisor) Dept. Chem.; Bio-Inorganic Chemistry UNM Prof. M. Ondrias, (Bell Lab Fellow) Dept. Chem.; Physical Chemistry UNM & Sandia National Laboratories (SNL) NM Prof. E. Walters, (Regent Chair) Dept. Chem.; Physical Chemistry UNM Prof. G. Kynner, (Emeritus, Brown Chair) Dept. Math & Computer Programming for Engineers; Applied Mathematics UNM Prof. M. Hampden-Smith, Dept. Chem.; Inorganic Chemistry UNM & National Institute of Materials and Surfaces NM Prof. F. Allen, (Dept Chair), Dept. Chem.; Analytical and Physical Chemistry UNM, founder of Chromex (bought out by Kaiser) Dr. P.J. Hay, Theoretical Division; Computational Chemistry Group, Los Alamos National Laboratory (LANL) NM