2 8 Mutation
- 1. 1. Convert the following mRNA strand into DNA : … CUGACGUACG…. 2. Take the following DNA strand through Central Dogma and produce the protein : GACATACTCAACTGCAATT
- 2. Convert the following mRNA strand into DNA: … CUGACGUACG… GACTGCATGC Take the following DNA strand through Central Dogma and produce the amino acid chain: GACATACTCAACTGCAATT CUGU AUG-AGU-UGA-CGUUAA Met- Ser-Stop
- 3. DNA and DNA replication (Mon) Transcription (Wed) CSI Las Vegas (Thu) Translation and Transcription Practice (Fri)
- 4. B1 B2 B3 B5
- 6. A mutation is a change in DNA sequence (order of nucleotides).
- 7. Mutations are important because they increase genetic variation .
- 8. Mutations can be good as well as bad. Ex: A Protein to run faster Ex: A protein that causes Sickle Cell Anemia
- 9. A mutagen is something that causes a mutation. Ex: radiation, chemicals, high temp.
- 10. There are 2 main types of gene mutations. Point mutations Frameshift mutations
- 11. Point mutation-a change in one base pair in a DNA sequence. Example: A U G=Met A A G=Lys
- 12. A point mutation may cause an amino acid to change, which will change the structure of the protein being made. We call this a MISSENSE mutation
- 13. Normal Point mutation mRNA Protein Stop Stop mRNA Protein Replace G with A
- 14. If the point mutation results in the same amino acid produced, we call this a SILENT mutation AG U AG C SER SER
- 15. Frameshift mutation- adding or deleting nucleotides to a DNA sequence. A frameshift mutation is much worse than a point mutation because it causes the entire sequence to be thrown off
- 16. A mutation the ends in an early stop codon is called a nonsense mutation.
- 17. DNA: THE CAT ATE THE HAT We get: HEC ATA TET HEH AT Delete this T
- 18. mRNA Protein Frameshift mutation
- 20. Is this a point mutation or a frameshift mutation? It’s a point mutation because only one nucleotide changed!
- 21. THE DOG BIT THE CAT THE DOG BIT THE CAR Point or frameshift? Point!
- 22. THE DOG BIT THE CAT THE DOB ITT HEC AT Point or frameshift? -frameshift