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Bio-Talk-Nowledge-y
Communicating the Science of Science Communication
Kevin M. Folta
Professor and Chair
Horticultural Sciences Department
kfolta.blogspot.com
@kevinfolta
kfolta@ufl.edu
"There is a path to truth and sincerity that you must
guard and defend“
-- Teruyuki Okazaki
1. Misuse of Science
1. Bad experiments, bad data, big impacts.
2. Good experiments, misrepresented.
2. What are your problems, your solutions?
Misuse of Science
For fame, fortune and political victories
There is money to be made in manufacturing risk.
Activists can hijack venues that appear scientific
Predatory publishing allows publication of work that lacks scientific rigor
What we’re seeing
Bad science --- lots of press!
Good science incorrectly interpreted
Manufacturing Risk
What are some facts about science and
publishing?
-- It is an ugly process!
-- It is the gold standard.
-- Everybody wants to be number 2!
-- Good science grows.
-- Science careers are tough. A breakthrough
changes everything.
2015 unc class
2015 unc class
2015 unc class
2015 unc class
2015 unc class
2015 unc class
2015 unc class
2015 unc class
2015 unc class
Number of Starbucks
Organic food sales
Wi Fi hotspots
Manufacturing the Perception of Risk
confusing correlation and causality
Manufactured Risk
Scientist claiming mysterious
GMO organism that causes
disease in humans, livestock and
plants (>8 years, no evidence)
Statistically-insignificant work
with missing controls
http://farmandranchfreedom.org/let
ter-dr-huber-roundup-animal-
miscarriage-infertility/
Seralini et al 2012
Figure 3
Bad Science and the “Link” to Tumors
2015 unc class
Moms Across America
2015 unc class
True or False?
Kathage and Qian 2012
2015 unc class
Good Science,
Badly represented.
2015 unc class
Change in
herbicide use
Change in
insecticide use
What the Report Really Said:
You could detect glyphosate at a few ng / m3
Measured 3-100 m outside of field.
Glyphosate replaced other herbicides
The use of GM cotton has reduced insecticide use, massively
2015 unc class
2015 unc class
How do we possibly know what to trust?
If it is true, more scientists will get invovled and
the discipline will expand.
Rely on peer-reviewed research, not websites.
Real breakthroughs will be in the best journals.
Correlations must lead to mechanisms.
GMO 2.0
Kevin M. Folta
Associate Professor and Chair
Horticultural Sciences Department
kfolta.blogspot.com
@kevinfolta
kfolta@ufl.edu
What are some of the challenges in
agriculture?
What are some of your solutions?
Technology Exists NOW
Research has been published demonstrating that
transgenic techniques can:
Biofortify foods with vitamins, minerals, phytonutrients
Grow plants in marginal areas
Grow plants with fewer inputs
Efficient use of fertilizers
Insect resistance
Disease resistance
Strawberries requiring less fungicide
Strawberries are the most fungicide-intensive crop
Overexpression of the NPR1 gene allows them to grow
in presence of high fungal pressure.
Plants overexpressing NPR1 were inoculated with a
series of pathogens and moved to warm, humid
conditions.
2015 unc class
Golden Rice
X
Farmers
Consumers
Environment
Needy
Opposition to golden rice cost $2 billion to
farmers in developing countries and 1.4
million human years – Wesseler et al., 2014
Cassava
Virus Resistant Cassava (VIRCA)
Biocassava Plus (BC Plus)
250 million depend on cassava
50 million tons lost to virus.
X
X Farmers
Consumers
Environment
Needy
Golden Bananas Beta carotene producing
X
Farmers
Consumers
Environment
Needy
Survives moderate drought, especially at key times like flowering
It is based on overexpression of a maize stress gene
Non transgenic transgenic
X
X Farmers
Consumers
Environment
Needy
Allergy-Free Peanuts
Peanut – RNAi suppression Ara h2 X
Farmers
Consumers
Environment
Needy
Allergy Free Wheat
Using RNAi to repress gliadin levels
BS2 Tomato
A pepper gene in tomato eases black spot and wilt.
X
X Farmers
Consumers
Environment
Needy
High Anthocyanin Tomato
A transcription factor excites anthocyanin production in fruits
X
X Farmers
Consumers
Environment
Needy
X
Longer shelf life too.
Acrylamide Free, non Browning Potatoes
X
X
Farmers
Consumers
Environment
Needy
Non Browning Apples
Silencing a gene that leads to discoloration
X
X
Farmers
Consumers
Environment
Needy
Small Business!X
Grapes resistant to Pierce’s Disease
X
X
Farmers
Consumers
Environment
Needy
X
Virus Resistant Beans
Embrapa, Brazil
Important Central American Crop
transgenic
Non-transgenic
2015 unc class
Improved Oil Composition
One acre of omega-3 producing soybeans yields as much oil as
10,000 fish!
Stopping Citrus Greening
Spinach defensin
NPR1
Lytic peptides
Many show promise
Earliest deregulation is
2019
Edible Cotton Seeds!
Gossypol- free
Defense compound to
protect seeds
Protein rich seeds
could feed 500 M
people
Transgenic cotton with
suppressed gossypol
synthesis
Edible Cotton Seeds!
Chestnut blight has
destroyed the American
Chestnut.
A single gene confers
resistance to the
disease.
Not food… so
deregulation is an
interesting question.
Bacterial Wilt in Bananas
>70% of calories for some areas
GM trials in Uganda
X
X
Farmers
Consumers
Environment
Needy
X
Where to Learn More
About the Pipeline?
www.isaaa.org
National Academies of Sciences
Academics Reviews
kevinfolta@gmail.com
@kevinfolta
Illumination (blog)
Biofortified.org
Genetic Literacy Project.com
gmoanswers.com
Provide a Trail to Good Information
Academics Review : GMOLOL on Facebook : GMO Skeptiform (facebook)
Illumination (my blog) :
In Conclusion
We have to be able to separate the legitimate science from
that which is a suspect.
We need to be able to better interpret actual science, and
note cases where interpretations overstep the data.
What are ways this technology can be used to solve
problems, helping farmers, consumers, the environment
and the needy?

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2015 unc class

  • 1. Bio-Talk-Nowledge-y Communicating the Science of Science Communication Kevin M. Folta Professor and Chair Horticultural Sciences Department kfolta.blogspot.com @kevinfolta kfolta@ufl.edu
  • 2. "There is a path to truth and sincerity that you must guard and defend“ -- Teruyuki Okazaki
  • 3. 1. Misuse of Science 1. Bad experiments, bad data, big impacts. 2. Good experiments, misrepresented. 2. What are your problems, your solutions?
  • 4. Misuse of Science For fame, fortune and political victories There is money to be made in manufacturing risk. Activists can hijack venues that appear scientific Predatory publishing allows publication of work that lacks scientific rigor What we’re seeing Bad science --- lots of press! Good science incorrectly interpreted
  • 6. What are some facts about science and publishing? -- It is an ugly process! -- It is the gold standard. -- Everybody wants to be number 2! -- Good science grows. -- Science careers are tough. A breakthrough changes everything.
  • 16. Number of Starbucks Organic food sales Wi Fi hotspots Manufacturing the Perception of Risk confusing correlation and causality
  • 17. Manufactured Risk Scientist claiming mysterious GMO organism that causes disease in humans, livestock and plants (>8 years, no evidence) Statistically-insignificant work with missing controls http://farmandranchfreedom.org/let ter-dr-huber-roundup-animal- miscarriage-infertility/
  • 18. Seralini et al 2012 Figure 3 Bad Science and the “Link” to Tumors
  • 22. True or False? Kathage and Qian 2012
  • 28. What the Report Really Said: You could detect glyphosate at a few ng / m3 Measured 3-100 m outside of field. Glyphosate replaced other herbicides The use of GM cotton has reduced insecticide use, massively
  • 31. How do we possibly know what to trust? If it is true, more scientists will get invovled and the discipline will expand. Rely on peer-reviewed research, not websites. Real breakthroughs will be in the best journals. Correlations must lead to mechanisms.
  • 32. GMO 2.0 Kevin M. Folta Associate Professor and Chair Horticultural Sciences Department kfolta.blogspot.com @kevinfolta kfolta@ufl.edu
  • 33. What are some of the challenges in agriculture? What are some of your solutions?
  • 34. Technology Exists NOW Research has been published demonstrating that transgenic techniques can: Biofortify foods with vitamins, minerals, phytonutrients Grow plants in marginal areas Grow plants with fewer inputs Efficient use of fertilizers Insect resistance Disease resistance
  • 35. Strawberries requiring less fungicide Strawberries are the most fungicide-intensive crop Overexpression of the NPR1 gene allows them to grow in presence of high fungal pressure. Plants overexpressing NPR1 were inoculated with a series of pathogens and moved to warm, humid conditions.
  • 37. Golden Rice X Farmers Consumers Environment Needy Opposition to golden rice cost $2 billion to farmers in developing countries and 1.4 million human years – Wesseler et al., 2014
  • 38. Cassava Virus Resistant Cassava (VIRCA) Biocassava Plus (BC Plus) 250 million depend on cassava 50 million tons lost to virus. X X Farmers Consumers Environment Needy
  • 39. Golden Bananas Beta carotene producing X Farmers Consumers Environment Needy
  • 40. Survives moderate drought, especially at key times like flowering It is based on overexpression of a maize stress gene Non transgenic transgenic X X Farmers Consumers Environment Needy
  • 41. Allergy-Free Peanuts Peanut – RNAi suppression Ara h2 X Farmers Consumers Environment Needy
  • 42. Allergy Free Wheat Using RNAi to repress gliadin levels
  • 43. BS2 Tomato A pepper gene in tomato eases black spot and wilt. X X Farmers Consumers Environment Needy
  • 44. High Anthocyanin Tomato A transcription factor excites anthocyanin production in fruits X X Farmers Consumers Environment Needy X Longer shelf life too.
  • 45. Acrylamide Free, non Browning Potatoes X X Farmers Consumers Environment Needy
  • 46. Non Browning Apples Silencing a gene that leads to discoloration X X Farmers Consumers Environment Needy Small Business!X
  • 47. Grapes resistant to Pierce’s Disease X X Farmers Consumers Environment Needy X
  • 48. Virus Resistant Beans Embrapa, Brazil Important Central American Crop transgenic Non-transgenic
  • 51. One acre of omega-3 producing soybeans yields as much oil as 10,000 fish!
  • 52. Stopping Citrus Greening Spinach defensin NPR1 Lytic peptides Many show promise Earliest deregulation is 2019
  • 53. Edible Cotton Seeds! Gossypol- free Defense compound to protect seeds Protein rich seeds could feed 500 M people Transgenic cotton with suppressed gossypol synthesis
  • 54. Edible Cotton Seeds! Chestnut blight has destroyed the American Chestnut. A single gene confers resistance to the disease. Not food… so deregulation is an interesting question.
  • 55. Bacterial Wilt in Bananas >70% of calories for some areas GM trials in Uganda X X Farmers Consumers Environment Needy X
  • 56. Where to Learn More About the Pipeline? www.isaaa.org
  • 57. National Academies of Sciences Academics Reviews kevinfolta@gmail.com @kevinfolta Illumination (blog) Biofortified.org Genetic Literacy Project.com gmoanswers.com Provide a Trail to Good Information Academics Review : GMOLOL on Facebook : GMO Skeptiform (facebook) Illumination (my blog) :
  • 58. In Conclusion We have to be able to separate the legitimate science from that which is a suspect. We need to be able to better interpret actual science, and note cases where interpretations overstep the data. What are ways this technology can be used to solve problems, helping farmers, consumers, the environment and the needy?