2015_ASD-PFO.pdf

ASE GUIDELINES & STANDARDS
Guidelines for the Echocardiographic Assessment of
Atrial Septal Defect and Patent Foramen Ovale: From
the American Society of Echocardiography and
Society for Cardiac Angiography and Interventions
Frank E. Silvestry, MD, FASE, Chair, Meryl S. Cohen, MD, FASE, Co-Chair, Laurie B. Armsby, MD, FSCAI,
Nitin J. Burkule, MD, DM, FASE, Craig E. Fleishman, MD, FASE, Ziyad M. Hijazi, MD, MPH, MSCAI,
Roberto M. Lang, MD, FASE, Jonathan J. Rome, MD, and Yan Wang, RDCS, Philadelphia, Pennsylvania;
Portland, Oregon; Thane, India; Orlando, Florida; Doha, Qatar; and Chicago, Illinois
(J Am Soc Echocardiogr 2015;28:910-58.)
TABLE OF CONTENTS
Target Audience 911
Objectives 911
Introduction 911
Development and Anatomy of the Atrial Septum 912
Normal Anatomy 912
Anatomy of Atrial Septal Defects and Associated Atrial Septal
Abnormalities 912
Patent Foramen Ovale 912
Ostium Secundum Atrial Septal Defect 913
Ostium Primum Atrial Septal Defect 915
Sinus Venosus Defects 915
Coronary Sinus Defects 916
Common Atrium 916
Atrial Septal Aneurysm 916
Eustachian Valve and Chiari Network 916
Imaging of the Interatrial Septum 917
General Imaging Approach 917
Three-Dimensional Imaging of the Interatrial Septum 917
Role of Echocardiography in Percutaneous Transcatheter Device
Closure 917
Transthoracic Echocardiography Imaging Protocol for Imaging the
Interatrial Septum 924
Subxiphoid Frontal (Four-Chamber) TTE View 924
Subxiphoid Sagittal TTE View 924
Left Anterior Oblique TTE View 924
Apical Four-Chamber TTE View 924
Modified Apical Four-Chamber TTE View (Half Way in Between
Apical Four-Chamber and Parasternal Short-Axis View) 924
Parasternal Short-Axis TTE View 924
High Right Parasternal View 924
Transesophageal Echocardiography Imaging Protocol for the Interatrial
Septum 925
Upper Esophageal Short-Axis View 925
Midesophageal Aortic Valve Short-Axis View 926
Midesophageal Four-Chamber View 926
Midesophageal Bicaval View 926
Mid-Esophageal Long-Axis View 926
3D TEE Acquisition Protocol for PFO and ASD 927
3D TTE Acquisition Protocol for PFO and ASD 927
3D Display 927
Intracardiac Echocardiographic Imaging Protocol for IAS 928
Assessment of Shunting 928
Techniques, Standards, and Characterization Visualization of Shunting:
TTE and TEE 928
Transcranial Doppler Detection/Grading of Shunting 931
Impact of Shunting on the Right Ventricle 932
Pulmonary Artery Hypertension 935
RV Function 935
From the Hospital of the University of Pennsylvania, Perelman School of Medicine,
Philadelphia, Pennsylvania (F.E.S.); Children’s Hospital of Philadelphia, Perelman
School of Medicine, Philadelphia, Pennsylvania (M.S.C., J.J.R., Y.W.);
Doernbecher Children’s Hospital, Oregon Health and Sciences University,
Portland, Oregon (L.B.A.); Jupiter Hospital, Thane, India (N.J.B.); Arnold Palmer
Hospital for Children, University of Central Florida College of Medicine, Orlando,
Florida (C.E.F.); Sidra Medical and Research Center, Doha, Qatar (Z.M.H.); and
University of Chicago Hospital, University of Chicago School of Medicine,
Chicago, Illinois (R.M.L.).
The following authors reported no actual or potential conflicts of interest in relation
to this document: Frank E. Silvestry, MD, FASE Chair, Meryl S. Cohen, MD, FASE
Co-Chair, Laurie B. Armsby, MD, FSCAI, Nitin J. Burkule, MD, DM, FASE, Jona-
than J. Rome, MD, and Yan Wang, RDCS. The following authors reported relation-
ships with one or more commercial interests: Craig E. Fleishman, MD, FASE, has
served as a consultant for W.L. Gore Medical; Ziyad M. Hijazi MD, MPH, MSCAI
has served as a consultant for Occlutech; Roberto M. Lang, MD, FASE, has
received grant support and served on the speakers bureau and advisory board
for Philips.
Attention ASE Members:
The ASE has gone green! Visit www.aseuniversity.org to earn free continuing
medical education credit through an online activity related to this article.
Certificates are available for immediate access upon successful completion
of the activity. Nonmembers will need to join the ASE to access this great
member benefit!
Reprint requests: American Society of Echocardiography, 2100 Gateway Centre
Boulevard, Suite 310, Morrisville, NC 27560 (E-mail: ase@asecho.org).
0894-7317/$36.00
Copyright 2015 by the American Society of Echocardiography.
http://dx.doi.org/10.1016/j.echo.2015.05.015
910

LV Function 935
Imaging of IAS and Septal
Defects 935
Patent Foramen Ovale 935
Atrial Septal
Aneurysm 938
Eustachian Valve and Chiari
Network 938
Assessment of ASDs:
Standards and
Characterization 939
Role of Echocardiography
in Transcatheter Device
Closure 941
Description of Available
Transcatheter Devices and
Techniques 942
Device Embolization and
Erosion 944
Imaging Modalities in
Transcatheter Guidance:
TTE, TEE, ICE 947
Intraprocedural Guidance of
Transcatheter
Interventions 949
ICE Guidance of PTC 950
Imaging the IAS Immediately
After the Procedure 951
Follow-Up 953
Conclusion 953
Notice and Disclaimer 954
References 954
TARGET AUDIENCE
This document is designed for
those with a primary interest
and knowledge base in the field
of echocardiography and for
other medical professionals with
a specific interest in the abnor-
malities of the interatrial septum
and the use of cardiac ultraso-
nography. This includes cardio-
vascular physicians, other
cardiovascular providers, cardiac
sonographers, surgeons, cardiac
interventionalists, neurologists,
residents, research nurses, clini-
cians, intensivists, and other
medical professionals.
OBJECTIVES
On completing the reading of
the proposed guideline, the par-
ticipants will better be able to
1. Describe the conventional two-
dimensional, three-dimensional,
and Doppler echocardiographic methodology required for optimal evalua-
tion and characterization of the interatrial septum from transthoracic echo-
cardiographic, transesophageal echocardiographic, and intracardiac
echocardiographic ultrasound technologies.
2. Describe the echocardiographic parameters to characterize the normal in-
teratrial septum and the abnormalities of atrial septal defect, atrial septal
aneurysm, and patent foramen ovale. This will include the best practices
for measurement and assessment techniques.
3. Identify the advantages and disadvantages of each echocardiographic tech-
nique and measurements of the interatrial septum as supported by the avail-
able published data.
4. Recognize which images should be used and measurements that should be
included in the standard echocardiographic evaluation of patients with
atrial septal defect, atrial septal aneurysm, and patent foramen ovale.
5. Explain the clinical and prognostic significance of the echocardiographic
assessment of atrial septal defect, atrial septal aneurysm, and patent fora-
men ovale, including not only the interatrial septum assessment, but also
evaluation of the chamber size and function and the pulmonary circulation.
6. Recognize what are the relevant features used to evaluate patients for po-
tential transcatheter (i.e., device) closure of atrial septal abnormalities.
7. Describe the important features and potential findings in the echocardio-
graphic assessment of the patient after surgical and transcatheter interven-
tions for atrial septal abnormalities.
INTRODUCTION
Atrial septal communications account for approximately 6%–10% of
congenital heart defects, with an incidence of 1 in 1,500 live births.1
The atrial septal defect (ASD) is among the most common acyanotic
congenital cardiac lesions, occurring in 0.1% of births and accounting
for 30%–40% of clinically important intracardiac shunts in adults.2-4
The patent foramen ovale (PFO) is more common and is present in
greater than 20%–25% of adults.5
The clinical syndromes associated
with ASD and PFO are extremely variable and represent a significant
health burden that spans pediatric and adult medicine, neurology, and
surgery. The evaluation of abnormalities of the interatrial septum and
their associated syndromes require a standardized, systematic
approach to their echocardiographic and Doppler characterization,
including the use of transthoracic echocardiographic (TTE), transeso-
phageal echocardiographic (TEE), and intracardiac echocardiographic
(ICE) ultrasound, three-dimensional (3D) imaging, Doppler, and
transcranial Doppler (TCD) modalities.
A thorough echocardiographic evaluation of PFO and ASD in-
cludes the detection and quantification of the size and shape of the
septal defects, the rims of tissue surrounding the defect, the degree
and direction of shunting, and the remodeling and changes in size
and function of the cardiac chambers and pulmonary circulation.
The emergence of 3D visualization, especially with the TEE-based
characterization of septal abnormalities has contributed incremental
information in the evaluation of the interatrial septum.6,7
As such, a
guideline document to integrate the available diagnostic modalities
is presented to aid clinical practice, training, and research.
Previous American Society of Echocardiography (ASE) guidelines
have focused on the description of performing a comprehensive trans-
esophageal examination, standards for acquisition and presentation of
3D echocardiographic imaging, echocardiographic guidance of intera-
trial defect device closure,and assessmentofthe right ventricle (RV).8-12
Guidelines for the comprehensive assessment of the interatrial septum
(IAS) have the potential to reduce variation in the quality of
echocardiographic studies, guide the complete characterization of
defects, standardize the measurements and techniques used to
describe the anatomy and physiology, and improve the assessment of
suitability for surgical and transcatheter therapies.
Abbreviations
2D = Two-dimensional
3D = Three-dimensional
AoV = Aortic valve
ASA = Atrial septal aneurysm
ASD = Atrial septal defect
ASO = Amplatzer septal
occluder
AV = Atrioventricular
CS = Coronary sinus
EV = Eustachian valve
DTI = Doppler tissue imaging
FDA = Food and Drug
Administration
IAS = Interatrial septum/
septal
ICE = Intracardiac
echocardiography
IVC = Inferior vena cava
LA = Left atrium/atrial
LV = Left ventricle/ventricular
PA = Pulmonary artery
PFO = Patent foramen ovale
Qp/Qs ratio = Pulmonary to
systemic blood flow ratio
RA = Right atrium/atrial
RT3DE = Real-time three-
dimensional
echocardiography
RUPV = Right upper
pulmonary vein
RV = Right ventricle/
ventricular
SCAI = Society for Cardiac
Angiography and Intervention
SVC = Superior vena cava
SVD = Sinus venosus defect
TCD = Transcranial Doppler
TEE = Transesophageal
echocardiography/
echocardiographic
TTE = Transthoracic
echocardiography/
echocardiographic
VTI = Velocity time integral
Journal of the American Society of Echocardiography
Volume 28 Number 8
Silvestry et al 911

As such, clinicians and researchers, device manufacturers, and reg-
ulatory agencies all stand to benefit from these standards, because
they will bring greater uniformity into clinical care, clinical trial design,
and the conduct of imaging core laboratories.
Finally, the echocardiographic and Doppler study of patients
before and after surgical and transcatheter therapies involving the
IAS also requires guidelines and standardization of the methodology.
The results of these therapies and their complications must be fully
and competently assessed, characterized, and reported by the mod-
ern echocardiography laboratory.
DEVELOPMENT AND ANATOMY OF THE ATRIAL SEPTUM
Normal Anatomy
Understanding atrial septal communications requires comprehension
of the underlying development and anatomy of the IAS.13
The atrial
septum has three components: the septum primum, septum secun-
dum, and atrioventricular (AV) canal septum. The sinus venosus is
not a component of the true atrial septum but is an adjacent structure
through which an atrial communication can occur.14
Septal defects
can be classified according to their anatomic location in the IAS
(Figure 1).
Figure 2 depicts a schematic of normal atrial septal development.
The atria first develop as a common cavity. At approximately
28 days of gestation, the septum primum, derived from the atrial
roof, begins to migrate toward the developing endocardial cushions.
During this transition, the space between the septum primum and
the endocardial cushion is termed the ‘‘embryonic ostium primum’’
or the ‘‘foramen primum.’’14
The septum secundum, in contrast, is
an infolding of the atrial roof rather than a true membranous struc-
ture; it develops adjacent to the developing truncus and to the right
of the septum primum.14
In the normal heart, the ostium primum
closes by fusion of the mesenchymal cells of the septum primum
(the so-called mesenchymal cap of the vestibular spine) with the supe-
rior and inferior endocardial cushions.14
The leading edge of the
septum secundum becomes the superior limbic band. By 2 months
into gestation, the septum secundum and septum primum fuse, leav-
ing the foramen ovale as the only residual communication. The flap of
the foramen ovale is termed the ‘‘fossa ovalis’’ and is formed by the
septum secundum, septum primum (which attaches on the left atrial
[LA] side of the septum secundum), and the AV canal septum.15
The
septum primum becomes contiguous with the systemic venous tribu-
taries to form the inflow of the superior and inferior vena cavae. The
sinus venosus septum is an adjacent structure to the atrial septum that
separates the right pulmonary veins from the superior vena cava
(SVC) and posterior right atrium (RA).15
The coronary sinus is sepa-
rated from the LA by a wall of tissue called the coronary sinus septum.
The anterosuperior portion of the atrial septum is adjacent to the right
aortic sinus of Valsalva. A more detailed description of atrial septum
development is available for additional information.14
Anatomy of Atrial Septal Defects and Associated Atrial
Septal Abnormalities
Patent Foramen Ovale. A (PFO is not a true deficiency of atrial
septal tissue but rather a potential space or separation between the
septum primum and septum secundum located in the anterosuperior
portion of the atrial septum (Figure 3A,B).16
It is not considered a true
ASD, because no structural deficiency of the atrial septal tissue is pre-
sent.14,17
The foramen remains functionally closed as long as the LA
pressure is greater than the RA pressure. In many cases, a PFO might
be only functionally patent and have a tunnel-like appearance,
because the septum primum forms a flap valve. The relative differ-
ences in left and RA pressure can result in intermittent shunting of
blood. A PFO can also be a circular or elliptical true opening between
the two atria. Some cases of PFO result from ‘‘stretching’’ of the supe-
rior limbic band of the septum secundum from atrial dilation and re-
modeling (Figures 4–6). In other cases, the septum primum is truly
aneurysmal and as such cannot completely close the atrial
communication18
(Figure 7). In fetal life, patency of the foramen ovale
is essential to provide oxygenated blood from the placenta to the vital
organs, including the developing central nervous system.18
After birth,
the foramen ovale generally closes within the first 2 months of age. Up
to 20%–25% of the normal population has a PFO present in adult-
hood.18-21
The incidence and size of a PFO can change with age. In an autopsy
study of 965 human hearts, the overall incidence of PFO was 27.3%,
but it progressively declined with increasing age from 34.3% during
the first 3 decades of life to 25.4% during the 4th through 8th decades
and 20.2% during the 9th and 10th decades.5
The size of a PFO on
autopsy in that series ranged from 1 to 19 mm in the maximal diam-
eter (mean 4.9 mm). In 98% of these cases, the foramen ovale was
1–10 mm in diameter. The size tended to increase with increasing
age, from a mean of 3.4 mm in the first decade to 5.8 mm in the
10th decade of life.5
For purposes of consistency in nomenclature, a ‘‘patent foramen
ovale’’ has been referred to when right to left shunting of blood has
been demonstrated by Doppler or saline contrast injection without
a true deficiency of the IAS. A ‘‘PFO with left to right flow’’ has
been referred to when the atrial hemodynamics have resulted in
opening the potential communication of the foramen, resulting in
left to right shunting of blood demonstrated by Doppler imaging
(Figures 4–6). When a PFO is stretched open by atrial
hemodynamics, thus creating a defect in the septum, it is referred
to as a ‘‘stretched’’ PFO. This can result in left to right or right to left
shunting of blood flow demonstrated by Doppler, depending on
the differences in the right and LA pressure.
Closure of the foramen ovale occurs by fusion of the septum pri-
mum and septum secundum at the caudal limit of the zone of overlap
Figure 1 Subtypes of atrial septal communications when
viewed from RA. PFO not illustrated.
912 Silvestry et al Journal of the American Society of Echocardiography
August 2015

of these structures. Incomplete fusion results in a pouch-like anatomic
region that, in most instances, communicates with the LA cavity.22
The phrase ‘‘LA septal pouch’’ refers to the blind pouch from the re-
sidual overlap of the septum primum and septum secundum and has
been suggested as a possible location for thrombus formation and em-
bolism.23-26
This can mimic LA myxoma.27
Ostium Secundum Atrial Septal Defect. An ostium secundum
ASD most often occurs as the result of a true deficiency of septum pri-
mum tissue; it is the most common form of a true ASD.28
The supe-
rior and posterior margins of the defect are composed of the septum
secundum, the anterior margin is composed of the AV canal septum,
and the inferior margin is composed of the septum primum and left
venous valve of the inferior vena cava.18
These defects can vary in
shape and can be elliptical or round (Figure 8). With large ostium
secundum defects, the septum primum is often nearly or completely
absent. In some cases, persistent strands of septum primum will be
present and will cross the defect, resulting in multiple
Figure 2 (A) The septum primum grows from the roof of the atria. (B) Fenestrations develop within the septum primum. (C) The
septum secundum develops by an infolding of the atrial walls. The ostium secundum acts as a conduit for right-to-left shunting of
oxygenated blood. (D) At the anterior superior edge of the fossa ovalis, the primum and secundum septa remain unfused, which con-
stitutes a PFO. Arrow denotes blood flowing through the PFO from the embryonic RA to the LA. The blue and pink dots represent the
development of the caval and pulmonary venous inflow to the atria. EC, endocardial cushion; FO, fossa ovalis; OP, ostium primum;
OS, ostium secundum; SP, septum primum; SS, septum secundum. Reproduced with permission from Calvert et al.16
Figure 3 (A) Photograph of autopsy specimen from LA perspective demonstrating PFO by way of the passage of a metal probe; it
also demonstrates adjacent structures. SP, septum primum; SS, septum secundum. Reprinted with permission from Cruz-Gonz
alez
I, Solis J, Inglessis-Azuaje I, Palacios IF. Patent foramen ovale: current state of the art. Rev Esp Cardiol 2008;61:738-751. (B) The
septum primum is dark green, and the septum secundum is light green. A PFO typically exists at the anterior superior border adjacent
to the aortic root. The arrow denotes the passage of blood through the PFO from the right to left atrium.
Volume 28 Number 8
Silvestry et al 913

communications and creating multiple fenestrations (Figures 9–12).
These ASDs typically range in size from several millimeters to as
large as more than 3 cm in diameter. For example, in an autopsy
series of 50 patients with secundum ASD, all the defects were
classifiable into one of four morphologic categories: (1) virtual
absence of the septum primum such that the ASD was the entire
fossa ovalis (n = 19, 38%); (2) deficiency of the septum primum
(n = 16, 32%); (3) a fenestrated septum primum creating multiple
ASDs (n = 2, 4%); and (4) fenestrations in a deficient septum
primum creating multiple ASDs (n = 13, 26%).29
These anatomic var-
iations can have significant implications for device closure and could
favor the use of devices designed for multiple fenestrations or require
multiple devices for closure. Secundum ASDs can enlarge over time
with age and cardiac growth.28
Figure 4 Two-dimensional TEE of a PFO (yellow arrow) in bicaval views (A) without and (B) with color Doppler in an adult patient.
Figure 5 Two-dimensional TEE of a ‘‘stretched’’ PFO (yellow arrow) in bicaval views (A and B) with color Doppler flow from left to right
in an adult patient. See also Video 1.
August 2015

An ostium secundum ASD is often amenable to percutaneous
transcatheter closure.30-33
The evaluation for the suitability of
transcatheter closure is reviewed in detail in the present document.
A rare form of ostium secundum ASD occurs when the superior
limbic band of the septum secundum is absent. In such cases, the atrial
communication is ‘‘high’’ in the septum, in close proximity to the SVC.
However, these defects should not be confused with the sinus veno-
sus defect of the SVC type. Importantly, the high ostium secundum
ASD is not associated with anomalous pulmonary venous return.
An absence of the septum secundum can also occur in the presence
of left-sided juxtaposition of the atrial appendages. Juxtaposition of
the atrial appendages describes the condition in which both atrial ap-
pendages (or one appendage and part of the other) lie beside each
other and to one side of the great arterial vessels. The juxtaposition
is commonly associated with significant congenital heart disease,
including transposition of the great vessels.34
In juxtaposition, the
normal infolding of the atrial roof (that forms the septum secundum)
often does not occur because the great arteries are positioned abnor-
mally (such as is seen with a double outlet ventricle or transposition of
the great arteries).18
Although these defects do not involve the vena
cavae, AV valves, pulmonary veins, or coronary sinus, it is important
to recognize how close the defect is to these surrounding structures
when considering catheter-based device closure.31
Ostium Primum Atrial Septal Defect. An ostium primum ASD
is a congenital anomaly that exists within the spectrum of an AV canal
defect (Figure 13). In early embryologic development, these defects
occur when the endocardial cushions fail to fuse because of abnormal
migration of mesenchymal cells.35
With an endocardial cushion
defect, the canal portion of the AV septum and the AV valves can
all be variably affected. Ostium primum ASD is otherwise known as
partial or incomplete AV canal defect; these names are used inter-
changeably. The defect is characterized by an atrial communication re-
sulting from absence of the AV canal portion of the atrial septum in
association with a common AV valve annulus and two AV valve ori-
fices. The AV valve tissue is adherent to the crest of the ventricular
septum such that no ventricular level shunt is present. The leaflets of
the two AV valves are abnormal with two bridging leaflets that straddle
from the RV to the left ventricle (LV) rather than a normal anterior
mitral valve leaflet and septal tricuspid valve leaflet. The bridging leaf-
lets (superior and inferior) meet at the ventricular septum and are thus
often erroneously termed ‘‘cleft mitral valve.’’ This term is indelibly in
the lexicon of congenital heart disease. However, it is more accurate to
use the left and right AV valves when describing an ostium primum
ASD because both valves will always be abnormal in this setting. AV
valve regurgitation through the so-called cleft is extremely common
because of an abnormality or absence of valve tissue.
The borders of an ostium primum ASD include the septum pri-
mum superiorly and posteriorly and the common AV valve annulus
anteriorly. Because these communications have the AV valve orifice
as one of the margins, percutaneous transcatheter device closure is
not possible.31
Sinus Venosus Defects. Sinus venosus defects are less common
than ostium secundum ASDs and are not true ASDs.28
These defects
occur as a result of a partial or complete absence of the sinus venosus
septum between the SVC and the right upper pulmonary vein (SVC
type) or the right lower and middle pulmonary veins and the RA (infe-
rior vena cava [IVC] type; Figures 14–16). In most cases of sinus
venosus defects of the SVC type, the right upper pulmonary vein is
connected normally but drains anomalously to the RA. However, in
some cases, the right pulmonary vein or veins will be abnormally
connected to the SVC superior to the RA. The shunt that occurs is
therefore similar to that seen in a partial anomalous pulmonary
venous connection in that the pulmonary venous flow is directed
toward the RA. The resulting left-to-right shunt is typically large.
Occasionally, the patient will be mildly desaturated because SVC
blood is able to enter the LA. Sinus venosus defects of the IVC type
Figure 6 (A) Two-dimensional ICE of a ‘‘stretched’’ PFO and (B) with color Doppler in an adult patient. Yellow arrow indicates the
septum secundum; white arrow, septum primum; blue arrow, left to right flow through PFO. See also Video 2.
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Silvestry et al 915

are more unusual and typically involve anomalous drainage of the
right middle and/or lower pulmonary veins. Sinus venosus defects
cannot be closed by device and typically require baffling of the right
pulmonary veins to the LA by way of an ASD patch. Reimplantation
of the SVC (Warden procedure) is sometimes required if the right pul-
monary veins are connected directly to the SVC.
Coronary Sinus Defects. A coronary sinus septal defect or an
‘‘unroofed’’ coronary sinus is one of the more rare forms of atrial
communication. In this defect, the wall of the coronary sinus within
the LA is deficient or completely absent (Figures 17–19). In a heart
without other major structural anomalies, LA blood enters the
coronary sinus and drains into the RA through the coronary sinus
os, which is typically enlarged to accommodate the increased flow.
When a patent left SVC is associated with a coronary sinus septal
defect, it is termed ‘‘Raghib syndrome.’’36
Contrast injection with agitated saline is often helpful to make the
diagnosis. Two-dimensional (2D) and 3D TEE could be particularly
useful in establishing the diagnosis and correlating with the surgical
findings.6,37
In the setting of partial coronary sinus unroofing,
percutaneous transcatheter device closure might be possible in
some cases.38,39
Common Atrium. Rarely, all components of the atrial septum,
including the septum primum, septum secundum, and AV canal
septum are absent, resulting in a common atrium.28,40-42
This is
typically seen in association with heterotaxy syndrome. Some
remnants of tissue might still be present in these patients.
Atrial Septal Aneurysm. An atrial septal aneurysm (ASA) is a
redundancy or saccular deformity of the atrial septum and is associated
with increased mobility of the atrial septal tissue. ASA is defined as
excursion of the septal tissue (typically the fossa ovalis) of greater
than 10 mm from the plane of the atrial septum into the RA or LA or
a combined total excursion right and left of 15 mm (Figure 10). The
prevalence ofASA is 2%–3%.43
ASA has beenassociatedwiththe pres-
ence of a PFO, as well as an increased size of a PFO, and an increased
prevalence of cryptogenic stroke and other embolic events. ASA has
also been associated with multiple septal fenestrations, and this should
be evaluated for carefully using color Doppler imaging.44-46
Eustachian Valve and Chiari Network. The eustachian valve is a
remnant of the valve of the IVC that, during fetal life, directs IVC flow
across the fossa ovalis. A large or prominent eustachian valve in the
setting of a PFO might indirectly contribute to paradoxical embolism
by preventing spontaneous closure of the foramen.47
The eustachian
valve extends anterior from the IVC–RA junction.
A Chiari network is a remnant of the right valve of the sinus veno-
sus and appears as a filamentous structure in various places in the RA,
including near the entry of the IVC and coronary sinus into the RA
(Figure 20). A Chiari network is present in 2%–3% of the general
population and is associated with the presence of PFO and ASA.48
Figure 7 Biplane TEE of IAS with PFO demonstrating excessive mobility of the fossa ovalis and an associated PFO (arrow). Contrast
is seen in the RA. See also Video 3.
August 2015

KEY POINTS
PFO
PFO is not a true deficiency of atrial septal tissue but rather a potential space or
separation between the septum primum and septum secundum that occurs in
up to 20%–25% of the population.
PFO is defined by the demonstration of right to left shunting by contrast or color
Doppler, and a ‘‘stretched’’ PFO is present when atrial hemodynamics have opened
the foramen and result in left to right or right to left shunting demonstrated by
Doppler imaging.
ASD
Ostium secundum ASD occurs as a deficiency in septum primum and is the most
common form of ASD.
Ostium secundum ASD is often amenable to percutaneous transcatheter closure.
Ostium secundum ASD defects can vary in shape and can be elliptical or round
and can contain multiple fenestrations.
Ostium primum ASD occur as a result a failure of fusion of the endocardial cush-
ions and are within the spectrum of AV septal defects.
Sinus venosus defects are not true ASDs and result from the absence of sinus ve-
nosus septum between right upper pulmonary veins and SVC (SVC type) or right
middle and lower pulmonary veins and RA (IVC type).
Coronary sinus defects (or unroofed coronary sinus) are not true ASDs and permit
a left-to-right shunt from the LA to coronary sinus to the RA.
ASA
ASA is defined as an excursion of septal tissue of 10 mm from the plane of the
atrial septum into the atrium or a total excursion of 15 mm.
IMAGING OF THE INTERATRIAL SEPTUM
General Imaging Approach
The most widely used ultrasound modality to evaluate the IAS is TTE,
which remains the preferred initial diagnostic modality for the detec-
tion and diagnosis of PFO, ASD, and ASA.20,49-61
TTE is especially
useful in small children in whom the ultrasound image quality will
typically permit a full diagnostic study. It can also be used for
patient selection and real-time transcatheter ASD or PFO closure pro-
cedural guidance in pediatric patients.31,57,62-64
TTE can be used for the initial evaluation of ASD and PFO in adults;
however, TEE is required to further characterize the atrial septal ab-
normalities, because the TTE image quality will not always permit a
comprehensive evaluation of the IAS. TEE is not invariably required
for assessment of a PFO if transcatheter closure is not being consid-
ered. Also, 2D and 3D TEE offers significant incremental anatomic in-
formation compared with TTE and should be performed in all adult
patients being evaluated for percutaneous transcatheter closure or sur-
gical therapy.31,65-67
In adults, TEE can identify the margins or rims of
the ASD (see section on Assessment of ASDs: Standards and
Characterization) and assess the surrounding structures (e.g., aorta,
cavae, pulmonary veins, AV valves, and coronary sinus).
ICE has been used extensively to guide percutaneous ASD/PFO
closure procedures and provides comparable (but not identical) imag-
ing to TEE. ICE is discussed extensively in the subsequent sections (see
sections on Intracardiac Echocardiographic Imaging Protocol for IAS
and Role of Echocardiography in Transcatheter Device Closure).
Contrast echocardiography with agitated saline plays an important
role in the evaluation of PFO and assessing residual shunts after trans-
catheter closure and has a more limited role in the diagnosis of
ASD.52,61,63,68-75
Contrast echocardiography and contrast TCD is
discussed further in sections on Assessment of Shunting; Techniques,
Standards, and Characterization Visualization of Shunting: TTE and
TEE; and Transcranial Doppler Detection/Grading of Shunting.
Table 1 summarizes the recommended general imaging approach
to atrial septal abnormalities stratified by the patient characteristics,
imaging modality, and intended application (e.g., diagnosis, proce-
dure selection or guidance, follow-up).
Three-Dimensional Imaging of the Interatrial Septum
Most recently, 3D TEE has been described to improve the visualiza-
tion of PFO and ASD, their surrounding tissue rims, and surrounding
structures and can be used for guidance during percutaneous trans-
catheter closure.6,7,53,63,65,66,76-81
Because the IAS is a complex,
dynamic, and 3D anatomic structure, limitations exist in its
evaluation using any single form of 2D echocardiography. The IAS
(and associated abnormalities such as ASD or PFO) does not exist
in a true flat plane that can be easily aligned or interrogated using
2D imaging. Both ASD and PFO exist in a wide variety of
heterogeneous sizes, shapes, and configurations (Figures 8 and 21).
Also, 3D imaging provides unique views of the IAS and, in
particular, allows for en face viewing of the ASD and surrounding
fossa, allowing for accurate determination of the ASD size and
shape. Furthermore, 3D imaging offers the potential to clearly and
comprehensively define the dynamic morphology of the defect,
which has been shown to change during the cardiac cycle. Also, 3D
imaging delineates the relationship of the ASD to the surrounding
cardiac structures and the rims of tissue surrounding it (Figure 22).
Two-dimensional biplane (or triplane) imaging, a feature of
currently commercially available 3D imaging systems, is a unique mo-
dality that takes advantage of 3D technology. The advantages of
biplane imaging include the display of simultaneous additional echo-
cardiographic views, with high frame rates and excellent temporal res-
olution. Complimentary simultaneously displayed orthogonal plane
imaging provides incremental information compared with that from
a single plane, and this imaging modality is uniquely suited to trans-
catheter procedure guidance. Numerous reports of the advantages
of 3D TEE in guiding catheter interventions have been published
and include the use of biplane imaging.7,65,66,80,82
Figure 23 illustrates
the use of biplane imaging during percutaneous transcatheter closure
of ASD before deployment of the device.
Also, 3D imaging allows for multiple acquisition modes, including
narrow-angle, zoomed, and wide-angle gated acquisition of multiple
volumes. Once 3D volumes are acquired, postprocessing using
commercially available 3D software packages such as QLAB (Philips,
Best, The Netherlands) or 4D Cardio-View (TomTec, Munich,
Germany) is performed to align the plane of the IAS with multiple
3D plane slices. This approach facilitates an assessment of the shape
of an ASD and allows for measurement of the en face diameters in mul-
tiple orthogonal views, without the potential for bias due to malalign-
ment of the ultrasound planes (Figure 24). The images should be
reviewed in both systole and diastole to assess for the dynamic change
in size that can occur. This 3D en face display can also aid in the recog-
nition and quantification of rim deficiencies, because the extent of the
deficiency relative to the surrounding structures such as the aorta can be
easily demonstrated and quantified. The distance between the defect
and the aorta can be easily measured, just as can the area of the defect
and length of rim deficiency when present.
Role of Echocardiography in Percutaneous Transcatheter
Device Closure
The role of TTE, TEE, and ICE during the assessment and
transcatheter management of ASD/PFO is essential.31,63,80,83
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Echocardiography in patients undergoing transcatheter closure is
critically important for appropriate patient selection, real-time proce-
dure guidance, assessment of device efficacy and complications, and
long-term follow-up.
TTE provides information about the type of defect, its hemody-
namic significance, and any associated anomalies and can be used
comprehensively in smaller pediatric patients for the diagnosis of
ASD and PFO and for patient selection and procedure guidance.
TTE has the advantage of offering unlimited multiple planes to eval-
uate the atrial septum, but it has limited ability to interrogate the lower
rim of atrial septal tissue above the IVC after device placement
because the device shadowing interferes with imaging in virtually
all planes. In addition, because the septum is relatively far from the
transducer, the image quality is often suboptimal in larger pediatric
and adult patients. If percutaneous closure is clinically indicated, a
detailed assessment of the IAS anatomy and surrounding structures
using TEE is typically required for patient selection and procedure
guidance or ICE for procedure guidance in such patients.
Figure 8 Three-dimensional TEE images of various shapes and sizes of ostium secundum ASD. Representative examples of (A)
round, small, (B) round, large, (C) oval, small, and (D) oval, large secundum ASD. See also Video 4. Reprinted with permission
from Seo et al.77
Figure 9 Subxiphoid TTE demonstrating multifenestrated IAS without and with color Doppler flow from left to right in a pediatric pa-
tient. See also Video 5.
August 2015

Transesophageal echocardiography provides real-time, highly
detailed imaging of the IAS, surrounding structures, catheters, and
closure device during transcatheter closure. It requires either
conscious sedation, with the attendant aspiration risk in a supine pa-
tient, or general anesthesia, with an endotracheal tube placed to
minimize aspiration risk. This approach also requires a dedicated
echocardiographer to perform the TEE, while the interventionalist
performs the transcatheter closure procedure. The advent of 3D
Figure 11 Three-dimensional TEE of one medium and one small ostium secundum ASDs (white arrows). (A) Bicaval view demon-
strating two discrete ASDs. (B) Bicaval view with color Doppler demonstrating two discrete left to right shunts. (C) Zoom acquisition
of both ASDs en face from RA perspective. (D) Minimally invasive surgical repair demonstrating identical pathologic findings to 3D
TEE.
Figure 10 Two-dimensional TEE (bicaval view) of IAS with ASA demonstrating excessive mobility of the fossa ovalis (A–C) and asso-
ciated multiple fenestrations (D–E) (yellow arrows).
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Silvestry et al 919

Figure 13 (A) Primum ASD by 2D TTE in apical four-chamber view. (B) Primum ASD by 2D TTE in subcostal left anterior oblique view.
CAVV, common AV valve.
Figure 12 Three-dimensional TEE of multiple secundum ASDs (white arrows) resulting in a ‘‘Swiss cheese’’ configuration. (A) Bicaval
view demonstrating at least two discrete ASDs with left to right color Doppler flow. (B) En face zoom acquisition from RA perspective
demonstrating four discrete ASDs. (C) Zoom acquisition after minimally invasive surgical repair with a single pericardial patch. See
also Videos 6 and 7.
August 2015

TEE has enhanced the evaluation of ASD and PFO by clearly defining
the IAS anatomy and enables an en face view of the defect and its sur-
rounding structures. Multiplanar reconstruction of the 3D data
set allows accurate measurement of the minimum and maximum di-
mensions of the defect or defects, facilitating selection of the optimal
size and type of closure device. Moreover, intraprocedural real-time
3D TEE provides superior visualization of wires, catheters and de-
vices, and their relationships to neighboring structures in a format
that is generally more intuitively comprehended by the interventional
cardiologist (Figure 25).
Figure 14 (A) Representative example of 2D TTE (left) and with color Doppler (right) of an SVC type sinus venosus ASD from the high
right parasternal view. (B) Representative example of 2D TTE (left) and with color Doppler (right) of an SVC type sinus venosus ASD
from the subcostal sagittal view. RPA, right pulmonary artery. See also Video 8.
Figure 15 Transthoracic echocardiogram of a SVC type venosus ASD in subxiphoid sagittal view without and with color in a pediatric
patient. The yellow arrow represents the right superior pulmonary vein and the white arrow, the defect entering the atrium. See also
Video 9.
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Intracardiac echocardiography has been used extensively to guide
percutaneous ASD/PFO closure procedures and is the imaging
modality of choice in many centers in the cardiac catheterization
laboratory.84-88
The advantages of ICE include an image quality
that is similar (but not identical) to that of TEE, facilitating a
comprehensive assessment of the IAS, location and size of the
defects, the adequacy of the rims, and location of the pulmonary
veins. It also retains an advantage compared with TEE in imaging
Figure 16 (A) Inferior vena cava type sinus venosus ASD by 2D TTE (left) and with color Doppler (right) in the parasternal short-axis
view with left to right flow. (B) IVC type sinus venosus ASD by 2D TTE in the subcostal view. See also Video 10.
Figure 17 (A) Two-dimensional TTE (left) and with color Doppler (right) demonstrating unroofed coronary sinus interatrial communi-
cation in four-chamber view. Note dilated CS. (B) Two-dimensional TTE (left) and with color Doppler (right) demonstrating unroofed
coronary sinus interatrial communication in subcostal left anterior oblique view. CS, coronary sinus. See also Videos 11 and 12.
August 2015

the inferior and posterior portions of the IAS.89
Finally, the use of ICE
eliminates the need for general anesthesia and endotracheal intuba-
tion and can be performed with the patient under conscious sedation.
An interventionalist can perform ICE without the need for additional
echocardiography support personnel. However, the potential disad-
vantages of ICE include a limited far-field view, catheter instability,
the expense of single-use ICE catheters, the need for additional
training, the risk of provocation of atrial arrhythmias, and increased
Figure 18 Two-dimensional TEE of unroofed coronary sinus. (A) Two-dimensional image demonstrating enlarged coronary sinus
with unroofing communicating with LA (arrow). (B and C) Color Doppler flow into the coronary sinus from the LA and into the RA,
creating an interatrial communication through the unroofed coronary sinus. (D) Two-dimensional image demonstrating enlarged cor-
onary sinus with unroofing communicating with LA (arrow). (B and E) Color Doppler flow into the coronary sinus from the LA and into
the RA, creating an interatrial communication through the unroofed coronary sinus. See also Video 13.
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Silvestry et al 923

technical difficulty for a single operator. Table 2 provides a summary
of the advantages and disadvantages of TTE, TEE, and ICE in percu-
taneous transcatheter guidance of PFO and ASD.
Transthoracic Echocardiography Imaging Protocol for
Imaging the Interatrial Septum
The atrial septum can be evaluated fully using TTE. Ideally, multiple
views should be used to evaluate the size, shape, and location of an
atrial communication and the relationship of the defect to its sur-
rounding structures (Figures 9 and 13–17 and 26–28). In particular,
special attention must be paid to determine the relationship of the
defect to the venae cavae, pulmonary veins, mitral and tricuspid
valves, and coronary sinus. Assessment of the amount of the
surrounding rims of tissue present is crucial. A deficiency of rim
tissue between the defect and pulmonary veins, AV valve, or IVC
will preclude transcatheter closure, and a deficiency of aortic rim
can increase the risk of device erosion in certain circumstances.
Additional views of other structures such as the ventricles and great
arteries are necessary to assess for secondary findings related to the
hemodynamic consequences of an ASD such as RA, right ventricular
(RV), and pulmonary artery (PA) dilation. In the pediatric population,
the subxiphoid window typically allows the best visualization of the
atrial septum and its related structures. In adolescence and adulthood,
the subxiphoid window is often inadequate because of the distance
from the probe to the atrial septum. Thus, other views such as the par-
asternal windows should be used to assess the atrial septum. In some
cases, a full assessment of the atrial septum might not be possible with
TTE. Thus, TEE could be required.
Subxiphoid Frontal (Four-Chamber) TTE View. The subxi-
phoid frontal (four-chamber) view allows imaging of the atrial septum
along its anterior–posterior axis from the SVC to the AV valves. This
is the preferred view for imaging the atrial septum, because the atrial
septum runs near perpendicularly to the ultrasound beam, providing
the highest axial resolution and permitting measurement of the defect
diameter along its long axis. Because the septum is thin (especially in
its midportion), placing the septum perpendicular to the ultrasound
beam helpsdistinguisha true defect fromdropout resultingfroman arti-
fact. Aneurysms of the atrial septum primum composed of tissue
attached to the edges of the ASD are also well visualized from the sub-
costal frontal view. ASAs could be fenestrated (Figure 9) but also can be
intact with no resultant atrial level shunt. Color Doppler interrogation
and contrast studies should be used to detect shunting. Thesurrounding
rimfromthedefecttothe right pulmonary veins can be measuredinthis
view. Sinus venosus defects will be difficult to visualize because the
venae cavae are not viewed longitudinally in this view.
Subxiphoid Sagittal TTE View. Thesubxiphoidsagittal TTE viewis
acquired by turning the transducer 90
clockwise from the frontal view.
This view is ideal for imaging the atrial septum along its superior–inferior
axis in a plane orthogonal to the subxiphoid frontal four-chamber
view. Sweeping the transducer from right to left in this axis allows
determination of the orthogonal dimension of the ASD (Figures 15
and 17). This dimension can be compared with the dimension
measured in the subxiphoid frontal view to help determine the shape
(circular or oval) of the defect. This view can be used to measure the
rim from the defect to the SVC and IVC and is an excellent window
to image a sinus venosus type defect (Figures 14B and 15).
Left Anterior Oblique TTE View. The left anterior oblique TTE
view is acquired by turning the transducer approximately 45
coun-
terclockwise from the frontal (four-chamber) view. This view allows
imaging of the length of the atrial septum and is therefore ideal to
identify ostium primum ASDs and for assessment of coronary sinus
dilation (Figures 13B and 17B). In addition, it allows evaluation of
the relation of the SVC to the defect. Furthermore, this view can be
used to evaluate the entrance of the right-sided pulmonary veins
into the heart.
Apical Four-Chamber TTE View. In the apical four-chamber TTE
view, the diagnosis and measurement of ASDs should be avoided
because the atrial septum is aligned parallel to the ultrasound beam.
Thus, artifactual dropout is frequently seen in this view, which could
result in overestimation of the defect size. This view is used to assess
the hemodynamic consequences of ASDs, such as RA and RV dila-
tion, and to estimate RV pressure using the tricuspid valve regurgitant
jet velocity. This view is also used to evaluate for right-to-left shunting
with agitated saline (Figure 29).
Modified Apical Four-Chamber TTE View (Half Way in Be-
tween Apical Four-Chamber and Parasternal Short-Axis
View). The modified apical four-chamber TTE view is obtained by
sliding the transducer medially from the apical four-chamber view
to the sternal border. This view highlights the atrial septum at an
improved incidence angle to the sound bean (30
–45
). In the pa-
tients in whom the subcostal views are difficult to obtain, the modified
apical four-chamber view is an alternative method for imaging the
atrial septum in the direction of the axial resolution of the equipment.
Parasternal Short-Axis TTE View. In the parasternal short-axis
TTE view at the base of the heart, the atrial septum is visualized pos-
terior to the aortic root running in an anterior–posterior orientation.
This view is ideal to identify the aortic rim of the defect (Figures 26
and 27). It also highlights the posterior rim (or lack thereof) in sinus
venosus and posteroinferior secundum defects. The size of the
defect itself should not be measured in this view, because the beam
orientation is parallel to the septum, and drop out resulting from
artifact can occur.
High Right Parasternal View. The high right parasternal view is a
parasagittal view performed with the patient in the right lateral decu-
bitus position with the probe in the superior–inferior orientation. In
Figure 19 Unroofed coronary sinus on 3D TEE image as viewed
from LA aspect. Oval indicates perimeter of unroofed portion of
sinus in LA.
August 2015

this view, the atrial septum is aligned perpendicular to the beam and is
ideal for diagnosing sinus venosus defects, particularly when the sub-
xiphoid windows are inadequate (Figure 16).
Table 3 summarizes the key imaging views for TTE for the evalua-
tion of the IAS and surrounding structures.
Transesophageal Echocardiography Imaging Protocol for
the Interatrial Septum
As with TTE, multiple and sequential TEE views should be used to
completely and systematically evaluate the IAS, the size, shape, and
location of any atrial communication present, and the relationship
of the defect to its surrounding structures. A comprehensive guide
to performing multiplane TEE has been previously published by the
ASE and the Society of Cardiovascular Anesthesiologists, and should
be referred to for recommendations on performing a comprehensive
TEE examination.11
We recommend sequential interrogation and the digital capture of
images starting from the standard views and then by stepwise in-
creases in the transducer angle in a series of 15
increments to pan
or sweep the ultrasound beam through the areas of interest. Two-
dimensional images should be optimized and color Doppler mapping
subsequently applied. The color Doppler scale can be reduced slightly
to approximately 35–40 cm/sec to capture low-velocity flow across a
small fenestration, PFO, or smaller ASD. Pulsed and continuous wave
Doppler should then be used to measure the velocity, direction, and
timing of flow in the representative views.
Capturing 3D volumes with and without color Doppler of the IAS
allows for even greater data acquisition without the need for sequen-
tial multiplane interrogation and acquisition and is discussed sepa-
rately in the section on 3D TEE Acquisition Protocol for PFO and
ASD.
When an ASD or PFO is present, attention must be given to deter-
mining the relationship of the defect to the venae cavae, pulmonary
veins, mitral and tricuspid valves, and coronary sinus. An assessment
of the amount of the surrounding rims of tissue is critical for evalua-
tion of patient candidacy for percutaneous transcatheter closure. A
deficient rim is defined as less than 5 mm in multiple sequential views,
and this should be evaluated in at least three sequential related multi-
plane views in 15
increments.
As with TTE, additional views of the other cardiac structures are
necessary to assess for secondary findings related to the hemody-
namic consequences of an ASD such as right heart and pulmonary
arterial dilation. Please refer to the ASE guidelines on comprehensive
TEE assessment and the assessment of the right heart.9-11
When using TEE, five base views are used to assess the IAS and sur-
rounding structures, which are summarized in Table 4. These key
views include the upper esophageal short-axis view, midesophageal
aortic valve (AoV) short-axis view, midesophageal four-chamber
view, midesophageal bicaval view, and midesophageal long-axis view.
Upper Esophageal Short-Axis View. The upper esophageal
short-axis view is obtained from the upper esophagus starting at multi-
plane angles of 0
, with stepwise sweeping and recording at 15
, 30
,
and 45
. This view facilitates imaging of the superior aspects of the
atrial septum, including the septum secundum, the roofs of the RA
and LA, and the surrounding great vessels (SVC and ascending aorta).
Entry of the right pulmonary veins can be demonstrated by insertion
Figure 20 Transthoracic echocardiogram from the RV inflow view demonstrating mobile Chiari network (yellow arrows) attached to
eustachian ridge.
Table 1 Imaging strategy in overall evaluation of atrial septal abnormalities
Patient population
Establishing diagnosis
of ASD or PFO
Imaging for transcatheter
procedure guidance
Routine postprocedure
follow-up study
Pediatric patients 35–40 kg TTE or TEE* TEE or ICE†
TTE
Pediatric patients 35–40 kg TTE, TEE, 3D TEE TEE, 3D TEE, or ICE†
TTE
Adult patients TTE, TEE, or 3D TEE TEE, 3D TEE, or ICE†
TTE
*Depending on body surface area and adequacy of image quality, TEE is highly recommended for assessment of an ASD but is generally performed
in intubated patients; if the weight is 35–40 kg, 3D TEE can be performed.
†
Some centers use ICE for procedure guidance of all defects; others use ICE for uncomplicated small ASD closure only, reserving TEE or 3D TEE for
complicated or larger septal defects.
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Silvestry et al 925

into the mid-esophagus and by clockwise rotation of the probe in
these views (Figure 30). Anomalous pulmonary venous drainage
and an SVC type sinus venosus defect can be noted in this view.
Midesophageal Aortic Valve Short-Axis View. The mideso-
phageal AoV short-axis view is obtained from the mid-esophagus
starting with a multiplane angle of approximately 30
and stepwise
sweeping through and recording additional views at 45
, 60
, and
75
. This progression of transducer angles allows transitional interro-
gation of the IAS from the AoV short-axis view to the modified bicaval
tricuspid valve view. The AoV short-axis view is typically obtained to
present short-axis views of the AoV and its surrounding septum. This
view facilitates imaging of the anterior and posterior planes of the atrial
septum (and aortic and posterior rims if an ASD is present), the ante-
roposterior diameter of the ASD, and the overlap of septum primum
and septum secundum when a PFO is present (Figures 31 and 32).
Midesophageal Four-Chamber View. The midesophageal four-
chamber view is obtained from the mid-esophagus beginning with a
multiplane angles of 0
and stepwise increases of the multiplane angle
to 15
and 30
. This view is used to evaluate the AV septum (deficient
in primum ASD) and the relationship of any ASD to the AV valves
(Figure 33). Larger devices used to close secundum ASD can interfere
or impinge on AV valve function, and this must be carefully evaluated
before device deployment (Figure 34).
Midesophageal Bicaval View. The midesophageal bicaval view is
obtained from the mid-esophagus with multiplane angles of 90
,
105
, and 120
. It is used to image the inferior and superior plane
of the atrial septum and the surrounding structures, such as the
SVC and right pulmonary veins (Figures 4, 5, 7, 10A–C,11A and B,
12A, 35, and 36). This view is important for evaluating sinus
venosus defects of the SVC type and to evaluate for anomalous
pulmonary vein insertion. This view is also important in evaluating
the roof or dome of the RA, which must be visualized before
release of ASD closure devices.
Mid-Esophageal Long-Axis View. The midesophageal long-axis
view is obtained from the mid-esophagus with multiplane angles of
Figure 21 Three-dimensional TEE images of a PFO. (A–C) Excessive movement of the septum primum (fossa ovalis) in a patient with
an ASA and a PFO. White arrow indicates PFO opened fully under influence of pressure difference between RA and LA. (D) PFO ‘‘tun-
nel’’ as viewed from the LA perspective. Blue arrow indicates the PFO exit into the LA. (E) PFO tunnel exiting into LA (white arrow).
Figure 22 Three-dimensional ASD assessment allows for delin-
eation of an ASD (blue arrow) and its relationship between adja-
cent structures—the aortic valve is seen and the entire aortic rim
(white arrow) is visualized en face.
August 2015

120
, 135
, and 150
to evaluate the roof or dome of the LA when a
percutaneous device is placed (see the section on the Role of
Echocardiography in Percutaneous Transcatheter Device Closure).
Rotation past the LA appendage demonstrates the entry of the left
pulmonary veins into the LA (Figure 37).
3D TEE Acquisition Protocol for PFO and ASD
Three-dimensional transesophageal images of the IAS should be ac-
quired from multiple views and multiple 3D imaging modes for anal-
ysis. A comprehensive description of overall 3D image acquisition,
formatting, and presentation can be found in the 2012 ASE guide-
lines.12
A comprehensive 3D examination usually begins with a real-time
or narrow-angled acquisition from the standard imaging views. To
obtain images with higher temporal and spatial resolution, electrocar-
diographically gated, 3D wide-angled acquisitions are then per-
formed. When evaluating the IAS using TEE, we recommend
narrow-angled, zoomed, and wide-angled acquisition of 3D data
from several key views:
Midesophageal short-axis view: acquired from the mid-esophagus starting at
a multiplane angle of 0
. The probe is rotated toward the IAS. This view is
particularly suited to narrow- and wide-angled acquisitions.
Basal short-axis view: acquired from the mid-esophagus starting at 30
to
60
multiplane angles. This view is particularly suited to narrow- and
wide-angled acquisitions. This view can also be used for zoom mode imag-
ing during procedure guidance. Processing the 3D images from this view fa-
cilitates the demonstration of an ASD en face and demonstrates the
relationship to the surrounding structures (e.g., the aorta and aortic rim)
(Figures 38 and 39A and B). Wide-angled acquisition from this view should
be acquired with and without color Doppler flow mapping for precise off-
line measurements of ASD size, shape, dynamic change, and relationship
to surrounding structures.
Bicaval view: acquired from the midesophageal level with the transducer
starting at the 90
to 120
multiplane orientation. This view can also be
captured by each of the 3D imaging modalities. The depth of pyramidal
data sets should be adjusted to include only the left and right sides of the
atrial septum in this view. This specific setting will allow the entire septum
to be acquired in a 3D format without incorporating the surrounding struc-
tures. With a 90
up–down angulation of the pyramidal data set, the entire
left-sided aspect of the septum can shown in an ‘‘en face perspective’’
(Figure 40). Once the left side of the atrial septum has been acquired, a
180
counterclockwise rotation will show the right side of the atrial septum
and the fossa ovalis as a depression on the septum (Figure 41). Sometimes
the use of fine cropping using the arbitrary crop plane will be necessary to
remove the surrounding atrial structures that can obscure the septum. A
gain setting at medium level is usually required to avoid the disappearance
of the fossa ovalis and creating a false impression of an ASD. This view is also
used to measure the size and shape of the ASD in systole and diastole.
Sagittal bicaval view: can be obtained from the deep transgastric position
with a transducer orientation of 100
to 120
. The recommendations for
the settings and processing are identical to the midesophageal bicaval view.
Four-chamber view: acquired from the midesophageal level starting at 0
to
20
transducer orientations.
3D TTE Acquisition Protocol for PFO and ASD. Transthoracic
3D images of the IAS can be obtained from the narrow-angle apical
four-chamber, narrow-angle parasternal long-axis color, and apical
four-chamber zoom views. However, image resolution can limit its
utility in larger pediatric and adult patients.
3D Display. When the IAS is viewed from the LA (left), the atrial
septum should be oriented with the right upper pulmonary vein at the
1-o’clock position. When displayed as viewed from the RA (right), the
SVC should be located at the 11-o’clock position (Figures 40 and 41).
Images should be acquired from these transducer positions as an
initial starting point using all three different 3D echocardiographic
modes, including narrow-angled, zoomed, and wide-angled gated
3D acquisition modes.
Multiple examples of images from each modality are provided in
the present report. In still images that are carefully acquired and
Figure 23 Biplane imaging performed during percutaneous transcatheter closure imaging of multiple planes simultaneously. The
aortic rim and superior rim is seen (left arrow) and device interaction with the aorta (left arrow) and atrial roof (right arrow) can be as-
sessed simultaneously.
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Silvestry et al 927

cropped, it will not always be apparent which 3D echocardiographic
mode was used. In video images, the 3D zoomed acquisition mode
will be noticeable by its slow volume rate and smooth images, and
the 3D wide-angled gated acquisition mode will be noticeable by
stitch artifacts, if present.
The qualitative anatomic parameters delineated from the 3D data
set should include the type of ASD (e.g., secundum, primum, sinus ve-
nosus, common atrium, or coronary sinus), location within the atrial
septum, shape, and orientation (Figures 8, 11, 12, and 39). The
ASD shape can be defined as oval, round, or triangular or, at times,
shaped somewhat like an egg or a pear or slightly irregular
(Figure 8). The ASD orientation is defined according to the long-
axis orientation of the defect as vertical, horizontal, oblique with an
anterior tilt, or oblique with a posterior tilt. Defects in which the
lengths of the long-axis and short-axis dimensions are within 1 mm
should be designated as round.
Quantitative analysis of ASD using 3D echocardiography should
include the maximum length, width, and area measured at atrial
end-diastole (Figure 24). The ASD dimensions should also be
measured at atrial end-systole to determine the change in the dimen-
sions during the cardiac cycle (dynamic ASD). The ASD dimensions
are measured in en face views from either the RA or LA perspective
using dedicated quantitative software. The parameters calculated can
include the percentage of change in ASD length, width, and area from
atrial end-diastole to atrial end-systole. Atrial end-diastole is defined as
the frame with the largest ASD dimension and atrial end-systole as the
frame with the smallest ASD dimension. The number of defects in the
atrial septum should be quantified if multiple.
Intracardiac Echocardiographic Imaging Protocol for IAS
A comprehensive assessment of the atrial septum, any septal defects,
and surrounding tissue rims can be performed with radial or phased
array ICE.83,90-93
The key ICE views used in the evaluation of the
IAS as described are listed in Table 5. The currently available ICE sys-
tems and their present specifications are listed in Table 6. The currently
available ICE systems do not have electronic beam steering or multi-
plane transducer angle capabilities. Instead, they offer a radial rota-
tional or phased area imaging plane that is manipulated by insertion
and withdrawal of the catheter, axial rotation, and, in the case of the
phased array systems, by manipulating the steering controls with
adjustable tension, such that the catheter can be held in a flexed posi-
tion in up to four directions (anterior, posterior, left, and right).
Insertion and withdrawal of the phased array ICE probe will result
in imaging more superiorly and inferiorly. Axial rotation allows for
sweeping of the image through multiple planes. Three-dimensional
ICE has recently become commercially available.94-96
Limited data
exist regarding the role of 3D ICE in percutaneous transcatheter
procedures at present. The use of 3D ICE offers the potential to
provide greater anatomic information during structural interventions
but requires additional investigation to fully define its role.95,97
A standard assessment of the IAS and surrounding structures is pre-
sented here and summarized in Table 5:
The phased array ICE probe is initially positioned in the mid-RA in a neutral
catheter position to visualize the tricuspid valve in the long axis. This is referred
to as the ‘‘home view’’ (Figure 42A). In this view, the RA, tricuspid valve, RV,
RVoutflow tract, pulmonary valve, proximal main PA, a portion of the AoV,
and any ASD that is present with adjacent septum in the partial short-axis view
can be seen. This view visualizes the lower portion of the AV septal rim.
From this position, applying posterior deflection of the posterior–anterior
knob and applying slight rightward rotation of the right–left knob will obtain
the septal long-axis view (Figure 42B).
Advancing the catheter cephalad will produce a bicaval view from which the
superior and inferior rims of an ASD and the defect diameter and configu-
ration can be measured (Figure 42C).
Rotation of the entire catheter handle clockwise until the intracardiac trans-
ducer is near the tricuspid valve, followed by slight leftward rotation of the
right–left knob until the AoVappears creates a septal short-axis view similar
to the TEE short-axis plane, with the difference being the near field in the
present view is the RA compared with TEE showing the LA (Figure 42D
and E). From this view, the diameter of the defect and the anterior (aortic)
and posterior rims can be measured (Figure 43).
There is, however, no true four-chamber view, because the ICE catheter sits
in the RA.
The initial echocardiographic assessment includes measurement of
the defect diameter in multiple orthogonal planes, the overall septal
length, and defect rims. If multiple defects are present, each should
be characterized and the distance separating them measured. Please
refer to the section on Imaging of IAS and Septal Defects:
Assessment of ASDs: Standards and Characterization, for the features
of an ASD that should be routinely described on imaging (Table 7).
KEY POINTS
Table 1 summarizes the recommended general imaging approach using TTE, TEE,
and ICE for evaluation of atrial septal abnormalities stratified by patient character-
istics, imaging modality, and intended application (diagnosis, procedure selection
or guidance, follow-up).
TEE provides superior image quality to TTE but is not always required (e.g., a PFO
that is not being contemplated for closure).
3D imaging provides unique views of the IAS and, in particular, allows for en face
viewing of an ASD and the surrounding structures for accurate determination of
ASD size and shape, to delineate the rims of surrounding tissue, and to determine
the relationship of the ASD to the surrounding cardiac structures.
Echocardiography in patients undergoing transcatheter closure is critically impor-
tant for appropriate patient selection, real-time procedure guidance, assessment
of device efficacy and complications, and long-term follow-up.
Table 2 summarizes the advantages and disadvantages of TTE, TEE, and ICE in
percutaneous transcatheter guidance of PFO and ASD.
Table 3 summarizes the key imaging views using TTE for the evaluation of the IAS
and surrounding structures.
Table 4 summarizes the key views using TEE to assess the IAS and surrounding
structures.
Table 5 summarizes the key views using ICE to assess the IAS and surrounding
structures.
ASSESSMENT OF SHUNTING
Techniques, Standards, and Characterization
Visualization of Shunting: TTE and TEE
Shunting, and the hemodynamic significance of shunting, across an ASD
or PFO is evaluated through a combination of structural imaging, color
flow Doppler mapping, and spectral Doppler interrogation. Associated
findings, including diastolic flattening of the ventricular septum and dila-
tation of the RA, RV, and/or PA, are all potential signs of significant left-
to-right shunting. The severity of dilatation is related to the relative
compliance of these structures, as well as to the size of the ASD.
The direction of shunting though an ASD is usually left to right and
is visualized using color flow Doppler. ASD shunt flow can be right to
left or bidirectional in the setting of significant pulmonary hyperten-
sion or significant impairment of RV compliance. Pulse wave spectral
Doppler can be used for the detection of bidirectional shunting, in
addition to color Doppler. The color scale settings should be adjusted
to optimize for the expected low velocity of shunting (i.e., 25–40 cm/
sec). Occasionally, higher velocity left-to-right shunting will be present
August 2015

owing to LA hypertension from mitral stenosis, impaired left ventric-
ular (LV) compliance, or LV outflow obstruction.
In patients with ASD, measurement of the maximal dimension
(width) using color Doppler has been correlated with the maximal
dimension of the defect orifice when measured surgically. For example,
in a small series of patients undergoing surgery, the TTE- and TEE-
measured ASD color flow Doppler jet width measurements demon-
strated correlation with the anatomic maximal dimension observed at
surgery. Both TTE and TEE color flow Doppler echocardiography of
the maximal jet width correlates with direct surgical measurement of
the defectand,therefore,might provideanestimation oftheASD diam-
eter.98
Significant pitfalls exist when solely using the diameters
measured by color Doppler to evaluate the size of an ASD; therefore,
2D or 3D measurements without color should be relied on. The vari-
ability in color quality between machine vendors and the variable color
settings can result in excessive color bleed over the atrial septal tissue,
resulting in an overestimation of the true defect size.
Shunt flow can be estimated by pulsed Doppler quantification of
the pulmonary (Qp) to systemic (Qs) blood flow ratio.99,100
This is
typically performed by pulse wave Doppler using TTE by
interrogation of the RV and LV outflow tracts. The method involves
measurement of the systolic velocity time integrals (VTIs) of the RV
and LV outflow, and the maximal systolic diameters of the
pulmonary and LV outflow regions. The diameters are then used for
calculation of the corresponding outflow tract areas, assuming the
outflow region to be circular. The mathematical estimation of the
area of the RV and LV outflow tract (pr2
) multiplied by the
corresponding VTI estimates the stroke volume for the right and
left ventricle, respectively. The Qp/Qs ratio estimation is then the
ratio of the pulmonary to systemic stroke volumes (RV stroke
volume/LV stroke volume). This method has been validated and
compared with oximetric methods in a small number of patients
with secundum ASD, including those with pulmonary
hypertension, mitral and tricuspid regurgitation, ventricular septal
Figure 24 Once 3D volumes are acquired, postprocessing using commercially available 3D software packages will align the plane of
the interatrial septum with multiple 3D plane slices. This approach facilitates an assessment of the shape of an ASD and allows for
measurement of en face diameters and area in multiple orthogonal views, without the potential for bias due to malalignment of the
ultrasound planes. See the section on Imaging of the Interatrial Septum: Imaging of the Interatrial Septum for more details.
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Silvestry et al 929

defect, and Eisenmenger complex.99
Semilunar valve regurgitation
modifies the stroke volume in proportion to the degree of regurgita-
tion and can limit the estimation of shunt flow when a significant de-
gree of regurgitation is present. A similar method has been used with
inflow velocity and AV valve annular dimensions in diastole and also
correlated with oximetric methods.101
Color flow Doppler can also detect shunting across a PFO; however,
the shunting is often intermittent and might not be readily detectable
Figure 25 Intraprocedural RT3D TEE provides superior visualization of wires, catheters, and devices and their relationships to neigh-
boring structures in a format that is generally more intuitively comprehended by the interventional cardiologist than 2D echocardiog-
raphy. An ostium secundum ASD has been closed with an Amplatzer device under RT3D TEE guidance. All views are shown from the
LA perspective. (A) The LA disc of the device opening in the LA. (B) View showing continued opening of the device. (C) An undersized
device with a residual defect. This device was removed and (D) a larger closure device used.
Table 2 Advantages and disadvantages of TTE, TEE, and ICE in percutaneous transcatheter guidance of PFO and ASD
Modality Advantages Disadvantages
TTE Readily available
Low cost
Unlimited multiple planes to evaluate IAS
Noninvasive
Does not require any additional sedation
Excellent image quality in pediatric patients
Image quality in larger patients could be suboptimal
Requires technologist or echocardiographer to perform study
during closure
Lower rim of IAS not well seen after device placement owing
to shadowing in virtually all views
TEE Improved image quality over TTE
3D technique adds incremental value over 2D technique in
evaluating ASD size, shape, location
Provides en face imaging that might be more intuitively
understood to nonimagers
Requires additional sedation or anesthesia to perform
Risks include aspiration and esophageal trauma
Could require endotracheal intubation if prolonged procedure
performed
Requires additional echocardiographic operator to perform
Patient discomfort
ICE Comparable image quality to TEE
Can be performed with patient under conscious sedation
Reduces procedure and fluoroscopy times
Superior to TEE for evaluating inferior aspects of IAS
Interventionalist autonomy (can perform without additional
support)
Invasive
Risks of 8F–10F venous access and catheter, including
vascular risk and arrhythmia
Role of 3D technique to be defined
Cost of single-use ICE catheters
Limited far field views with some systems
Need for additional training of ICE operator
Operator might have two tasks (imaging and procedure)
August 2015

using color flow Doppler. When a PFO is stretched by differences in the
LA and RA pressure, a left-to-right color Doppler shunt might be seen
(Figures 4–6). First-generation contrast echocardiography with agitated
saline combined with physiologic maneuvers to provoke right-to-left
shunting, increases the sensitivity of PFO detection.102-105
The
microbubbles generated with agitation are too large to pass through
normal pulmonary vasculature and are easily detected by
echocardiographic imaging because of their increased echogenicity
(Figure 29). The provocative maneuvers used to transiently increase
RA pressure include the Valsalva maneuver and cough.
Transthoracic echocardiography with first-generation contrast can
be used to detect PFOs with reasonable sensitivity and specificity;
however, TEE is considered the reference standard for detection of
a PFO. Whether using TTE or TEE, the accuracy of the test will be
improved by the use of a standardized protocol that includes multiple
injections of agitated saline with provocative maneuvers to transiently
increase the RA pressure.50,106,107
An example of a protocol used by
many laboratories is presented:
Intravenous catheter, typically placed in antecubital vein, connected to a
three-way locking stopcock
Combine in 10-mL syringe connected to the stopcock 8 mL of saline plus
1 mL of blood from the patient plus 1 mL air; the addition of blood to
the contrast solution results in increased intensity of the microbubbles de-
tected by echocardiography108
Many laboratories prefer to avoid the use of the patient’s blood in the
contrast mixture preparation, and this can result in diagnostic quality opaci-
fication; in such cases, approximately 9 mL of saline and 1 mL of air are used
Rapidly mix back and forth with an empty 10-mL syringe attached to the
stopcock to manufacture bubbles
Inject rapidly into the antecubital vein while acquiring a long clip length (i.e.,
10 seconds) with the echocardiography system; the echocardiographic im-
ages are usually recorded from the four-chamber view for TTE, and the
angle best profiling the atrial septum is used for TEE, usually 30
–100
The use of biplane imaging might enhance detection of a small right-to-left
shunt
Theappearance of microbubbles in the LAwithin 3–6 cardiac beats
after opacification of the RA is considered positive for the presence of
an intracardiac shunt such as a PFO (Figure 29). Ideally, bubbles will be
visualized crossing the atrial septum through the PFO (Figure 38).
Physiologic maneuvers to transiently increase RA pressure are typi-
cally required to promote right-to-left shunting of microbubbles to
identify a PFO when no shunting is present without provocation.
The Valsalva maneuver using held expiration and release is one com-
mon maneuver performed. The Valsalva strain must be held long
enough for microbubbles to fill the RA. The effectiveness of the
Valsalva maneuver can be assessed echocardiographically by the pres-
ence of a leftward shift of the atrial septum with release of Valsalva,
indicating the achievement of RA pressure greater than LA pressure.
The appearance of microbubbles in the LA after 3–6 cardiac beats
indicates intrapulmonary shunting, such as an arteriovenous malfor-
mation. Intrapulmonary shunting is confirmed when the bubbles
are visualized entering the LA from the pulmonary veins and not visu-
alized crossing the atrial septum. Other reasons for a false-positive
bubble study for PFO are sinus venosus septal defect or other uniden-
tified ASD or pseudocontrast caused by the strain phase of Valsalva
with transient stagnation of blood in the pulmonary veins.
Bubble studies can result in false-negative findings because of inad-
equate opacification of the RA, an inadequate Valsalva maneuver, the
presence of a eustachian valve directing venous return from the IVC
to the atrial septum (preventing microbubbles entering from the SVC
to cross the atrial septum), an inability to increase the RA pressure
above the LA pressure such as in the presence of LV diastolic dysfunc-
tion, and poor image quality.70,109
In patients with poor image quality,
the use of second-harmonic imaging can improve the identification
and detection of microbubbles. Digital compression algorithms can
decrease the sensitivity for detection of small intracardiac shunts,
and some laboratories have continued to record contrast studies on
analogue videocassette to maximize the sensitivity for the detection
of small shunts.110
Specific routes of saline contrast administration for bubble studies
can be used in specific clinical scenarios. For example, a left antecubi-
tal vein saline contrast injection can be used to diagnose a persistent
left SVC draining into the coronary sinus. Leg vein saline contrast
administration can be used in the adult patient who has undergone
ASD closure but has persistent cyanosis after the procedure, because
an inferior sinus venosus ASD might have been incompletely closed,
with persistence of IVC flow into the LA. A leg vein injection also can
rarely be used to overcome a very large Chiari or eustachian network
that might impede the bubbles entering the RA from the SVC.
Sedated patients can have difficulty performing an adequate
Valsalva maneuver, as described in the section on Techniques,
Standards, and Characterization Visualization of Shunting: TTE and
TEE. In that circumstance, pressure on the abdomen can be applied
to transiently increase the RA pressure. If the patient is under general
anesthesia, the Valsalva maneuver can be mimicked by held inspira-
tion and then release. Reports have included attempted quantification
of right-to-left shunting based on the number of microbubbles appear-
ing in the left heart on an echocardiographic still frame; however, this
number is dependent on the amount of microbubbles injected and
the adequacy of the Valsalva maneuver.
Transcranial Doppler Detection/Grading of Shunting
Transcranial Doppler is an alternative imaging method for the detec-
tion of a PFO. This method uses power M-mode Doppler interroga-
tion of the basal cerebral arteries to detect microbubbles that have
crossed right to left into the systemic circulation. Specialized equip-
ment is used to focus the ultrasound system and display the results.
As with contrast-enhanced TTE and TEE, TCD studies are performed
with normal respiration and with the Valsalva maneuver to maximize
the sensitivity and specificity of the test. The results are reported refer-
enced to a six-level Spencer logarithmic scale, and higher grades have
been associated with larger right-to-left shunts.111,112
The advantages of TCD over TEE and TTE include increased pa-
tient comfort (compared with TEE), semiquantitative assessment of
shunt size, and the ability to identify extracardiac and intracardiac
shunting. The identification of extracardiac shunts is also a limitation
of TCD, because no anatomic information is provided regarding the
location of the shunt or associated abnormalities. Hence, TCD and
contrast echocardiography can be complementary techniques for
the evaluation of right-to-left shunting.113
Some laboratories prefer
to combine modalities and perform simultaneous contrast-
enhanced TTE or TEE with TCD.
The detection and grading of shunting by any technique is compli-
cated by physiologic variations in the presence and/or timing of the
shunting. Respiratory phasic changes in RA pressure can result in de-
layed right-to-left shunting and misclassification of interatrial flow as
an intrapulmonary shunt.70
Elevated LA pressure from LV failure,
mitral stenosis, or mitral regurgitation can prevent right-to-left shunt-
ing, because higher RA pressure is required to overcome the elevated
LA pressure. In a study comparing patients with versus without left
heart disease, the detection of PFO was 5% in the patients with left
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Silvestry et al 931

heart disease and 29% in those without left heart disease, similar to
that in the general population.114
Impact of Shunting on the Right Ventricle
Echocardiographic evaluation of hemodynamic changes to the RV
has been described in detail in previous Guidelines documents.9,115
The hemodynamic effects of ASD are primarily related to the
direction and magnitude of shunting, which is determined by the
size of the defect, the relative compliance of the RVs and LVs, and
the relative systemic and pulmonary vascular resistances. In most
patients, the greater compliance of the RV compared with the LV,
and the lower resistance of the pulmonary compared with the
systemic circulation, results in a net left-to-right shunt. The most
Figure 26 (A) Two-dimensional TTE of ostium secundum ASD from parasternal short-axis view. (B) Two-dimensional TTE (left) and
with color Doppler (right) of an ostium secundum ASD from the parasternal short-axis view with measurement of the diameter in the
anterior–posterior orientation and left to right flow by color Doppler. Ao, aortic root.
Figure 27 TTE of a secundum type ASD in the parasternal short-axis view without and with color Doppler in pediatric patient. See also
Video 14.
August 2015

Figure 28 (A and B) Examples of ostium secundum by 2D TTE (left) and with color Doppler (right) in the subcostal left anterior oblique
view. (A) Measurement of the ASD diameter (left) and left to right color Doppler flow (right). (C) Sagittal subcostal view in a patient with
secundum ASD. RPA, right pulmonary artery.
Figure 29 TTE of an apical four-chamber view during saline contrast injection. (A) Initial images demonstrate prominent artifact over
mitral valve. (B) Complete opacification of the RA and RV. (C) Delayed entry of contrast into the LA and LV, consistent with a pulmo-
nary arteriovenous malformation. If the bubbles cross within the first three cardiac cycles, an intracardiac shunt is present. Subse-
quent cardiac cycles (D and E) demonstrate continued opacification of the LA and LV consistent with intrapulmonary shunting. See
also Videos 15 and 16. Video 14 demonstrates the above sequence. Video 16 is an ICE image demonstrating a PFO, with immediate
passage of saline contrast from right to left, seen clearly to cross a PFO. INJ, injection.
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Silvestry et al 933

pronounced echocardiographic finding associated with this left-to-
right shunt is dilatation of the RV.
RV linear dimensions are best measured from a RV–focused apical
four-chamber view. Care should be taken to obtain the image demon-
strating the maximum diameter of the RV without foreshortening.
This can be accomplished by ensuring that the crux and apex of
the heart are in view. An RV diameter greater than 41 mm at the
base and greater than 35 mm at the midlevel indicates RV dilatation.
Similarly, a longitudinal dimension greater than 83 mm indicates RV
enlargement.115
The RVarea has been shown to correlate with the cardiac magnetic
resonance-derived RV volume and can serve as a semiquantitative
surrogate for the identification of RV dilatation.116,117
The 3D
echocardiographically derived RV volume is the most accurate
echocardiographic method to estimate the RV volume compared
with cardiac magnetic resonance. Compared with 2D techniques,
3D echocardiography results in better reproducibility and less
underestimation of the RV volume.118-120
An RVend-diastolic volume
indexed to the body surface area of 87 mL/m2
or greater for men and
74 mL/m2
or greater for women is considered increased.121
In the
setting of significant RV dilatation, it can be difficult to enclose the
entire RV in the 3D volume of interest for calculation of the volume.
The interventricular septal shape/ventricular configuration is
another marker of RV size. As the RV dilates in the setting of volume
overload, such as left-to-right shunting through an ASD, the interven-
tricular septum becomes displaced toward the LV in diastole, resulting
in a flattened appearance compared with the normal round appear-
ance in the normal heart. In addition to the diastolic septal flattening
associated with RV volume overload, systolic septal flattening can also
be present in those patients with an ASD who have associated pulmo-
nary hypertension. Visual assessment of the diastolic and systolic ven-
tricular septal curvature, looking for a D-shaped pattern, should be
used to help in the diagnosis of RV volume and/or pressure overload.
Although a D-shaped ventricle formed by flattening of the septum is
not diagnostic in RVoverload. With its presence, additional emphasis
should be placed on the confirmation, as well as the determination, of
the etiology and severity of right-sided pressure and/or volume over-
load.9
The severity of septal flattening increases with increasing RV
dilatation and has been quantified with an eccentricity index derived
from the perpendicular LV minor axis dimensions from the paraster-
nal short-axis view.122
The ratio of the minor axis diameter parallel to
the ventricular septum compared with the minor axis diameter that
bisects the ventricular septum can be calculated at end-diastole. A ra-
tio greater than 1 is associated with RV volume overload.
Table 3 TTE views for assessment of atrial septal anatomy
View Example Septal anatomy Procedural assessment
Subxiphoid long-axis (frontal)
or left anterior oblique (45
)
Right pulmonary vein ASD rim,
atrial septal defect diameter,
and atrial septum length
Position of device with regard
to right pulmonary veins and
assessment for residual leak
Subxiphoid short-axis (sagittal) SVC and IVC rim and atrial septal
defect diameter
Position of device with regard to
SVC and IVC and assessment
for residual leak
Apical four-chamber Rim of defect to AV valves,
assessment of RV dilation
RV pressure estimate from
tricuspid regurgitation jet
Position of device with regard
to AV valves
Parasternal short-axis Aortic and posterior atrial wall
rim, atrial septal defect diameter,
assessment of RV dilation
Device relationship to aortic valve,
assessment for impingement on
aorta or straddle, and relationship
of device to posterior wall
August 2015

Pulmonary Artery Hypertension
The pulmonary vasculature normally accommodates the increased
volume of flow secondary to ASD without a significant increase in
PA pressure. With continued RV volume overload and increased
PA flow over time, a small percentage of patients will develop pulmo-
nary hypertension, with an even smaller percentage developing irre-
versible pulmonary vascular disease.123
The type of ASD is also
associated with the frequency and rapidity of development of pulmo-
nary hypertension, with the sinus venosus defect more frequently
associated with pulmonary hypertension than secundum ASD and
at younger ages.124
Evaluation for pulmonary hypertension is there-
fore an important part of the echocardiographic evaluation of an
ASD before intervention. The systolic PA pressure is best estimated
from the RV systolic pressure using the tricuspid regurgitation jet ve-
locity (V) and the simplified Bernoulli equation: RV systolic
pressure = 4(V)2
+ estimated RA pressure. The normal peak RV sys-
tolic pressure should be less than 30–35 mm Hg. The PA diastolic
pressure can be similarly estimated from the pulmonary regurgitation
end-diastolic velocity, and the mean PA pressure can be estimated
from the peak PA velocity.125,126
Although accurate estimates of PA
pressure can be calculated using noninvasive techniques,
noninvasive estimation of the pulmonary vascular resistance is
more problematic. However, it has been described using a ratio of
peak tricuspid regurgitation velocity (in meters per second)
compared with the RV outflow tract VTI (in centimeters).125
RV Function
In general, RV function (systolic or diastolic) is not adversely affected
by the presence of an ASD; however, in some settings, RV function
will be impaired, such as in the presence of significant pulmonary hy-
pertension. When an evaluation of RV systolic function is required,
the methods available include dP/dt, myocardial performance index,
tricuspid annular plane systolic excursion, RV fractional area change,
RV ejection fraction from 3D volumetric evaluation, Doppler tissue
imaging (DTI) S0
velocity, DTI isovolumic myocardial acceleration,
and deformation evaluation with RV strain and strain rate. For evalu-
ation of RV diastolic function, the methods include transtricuspid E
and A wave velocities, E/A ratio, DTI E0
and A0
velocities, E/E0
ratio,
isovolumic relaxation time, and deceleration time. The reader is
referred to the recent Guidelines describing the ‘‘Echocardiographic
Assessment of the Right Heart in Adults’’ for details regarding the per-
formance of these techniques and their strengths and weaknesses.9
LV Function
Age-related LV diastolic dysfunction can lead to increased left-to-right
shunting across an ASD with associated worsening of RV volume
overload and late presentation of symptoms in older adults. These pa-
tients are also at increased risk of acute heart failure with pulmonary
edema after closure of their ASD. This acute presentation is thought
to be secondary to the combination of acute volume loading of
the left heart in the setting of LV diastolic dysfunction that becomes
unmasked with closure of the ASD.127,128
Preprocedural
echocardiographic evaluation of LV diastolic function with
assessment of mitral inflow and annular velocities can identify some
of these patients at risk of post-ASD closure heart failure and pulmo-
nary congestion. However, LV diastolic dysfunction can be masked by
the ASD and pressure equalization between the left heart and right
heart.129
In those cases, invasive test occlusion of the ASD and mea-
surement of the LA pressure can identify those patients at risk of
developing pulmonary edema. Pre-ASD closure treatment with di-
uretics and afterload reduction will help prevent post-ASD closure
heart failure. If medical therapy is not adequate to decrease the LA
pressure, a fenestrated ASD closure device can be used to avoid
the development of acute left heart failure.
KEY POINTS
The direction of shunting through an ASD by color Doppler is typically left to right.
The color scale settings should be optimized for the expected low velocity of shunt
flow (i.e., 25–40 cm/sec).
ASD shunt flow can be right to left or bidirectional in the setting of significant pul-
monary hypertension or impaired RV compliance. Pulse wave spectral Doppler
can be used for detection of bidirectional shunting in addition to color Doppler.
Color flow Doppler can detect shunting across a PFO when it has been stretched
open by differences in atrial pressure; however, the shunting is often intermittent
and might not be readily detectable using color flow Doppler.
TTE with first-generation contrast can be used to detect a PFO; however, TEE is
considered the reference standard for detection of a PFO.
Whether using TTE or TEE, accuracy will be improved by the use of a standardized
contrast protocol that includes multiple injections of agitated saline with provoca-
tive maneuvers to transiently increase the RA pressure.
The appearance of microbubbles in the LA after 3–6 beats indicates intrapulmo-
nary shunting, such as an arteriovenous malformation.
Bubble studies can provide false-negative findings owing to inadequate opacifica-
tion of the RA, an inadequate Valsalva maneuver, a prominent eustachian valve
directing venous return from the IVC to the IAS and preventing microbubbles
entering from the SVC to cross the IAS, an inability to increase the RA pressure
above the LA pressure, and poor image quality.
TCD is an alternative method for the detection of a PFO with advantages that
include increased patient comfort (compared with TEE), semiquantitative assess-
ment of shunt size, and the ability to identify extracardiac and intracardiac shunting.
The most pronounced echocardiographic finding associated with a left-to-right
shunt is dilatation of the RV, for which multiple echocardiographic methods are
available for measurement.
Echocardiographic assessment of the magnitude of shunting by Qp/Qs estimation
and the assessment of RV function completesthe assessment of patients with an ASD.
IMAGING OF IAS AND SEPTAL DEFECTS
Patent Foramen Ovale
The occurrence of a PFO is common, present in 20%–25% of the
population,5,130
and the anatomy has been extensively discussed
earlier in the present document. PFO has been associated with
cryptogenic stroke, decompression sickness, platypnea-orthodeoxia
syndrome, and migraine headache.131-138
Controversy exists
regarding the role of PFO in these syndromes, and currently, the
Food and Drug Administration (FDA) has not approved a role for
transcatheter procedures to close the PFO in an attempt to
decrease the incidence of these problems. Echocardiography has a
central role in the evaluation of PFO and monitoring/guidance of
PFO closure, similar to its role in ASD closure.
A TTE evaluation of PFO, including the use of agitated saline
contrast, is primarily used to identify the presence or absence of a
PFO according to the presence or absence of right-to-left shunting.
Once a PFO has been identified, and percutaneous device closure is be-
ing considered, a detailed evaluation of the atrial septal anatomy is per-
formed using TEE. TEE can also be used if a PFO is suspected; however,
TTE is technically inadequate to rule out the presence of a PFO.
The TEE views used for the evaluation of a PFO are similar to those
used for the evaluation of an ASD. Starting in the transverse plane at
the mid-esophagus with settings optimized to visualize the atrial
septum, the TEE imaging plane should be rotated or steered, starting
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Silvestry et al 935

at a 0
multiplane angle, in 15
increments, for complete evaluation of
the atrial septum. Side-by-side imaging with color Doppler at a low co-
lor Doppler scale is helpful for identifying flow through the PFO and
possible additional defects in the atrial septum. The probe will need to
be withdrawn for better evaluation of the atrial septum near the SVC
and inserted for better evaluation of the atrial septum near the IVC.
Alternatively, an initial evaluation of the atrial septum can be per-
formed in the transverse plane, starting at the high esophageal level
at the SVC and advancing the probe in the esophagus, imaging
through the fossa ovalis and ending at the level of the IVC. A similar
maneuver can be performed with the imaging plane at 90
–120
.
Starting at 30
–50
, with the AoV in cross-section, the PFO should
be visualized adjacent to the aorta. Rotation of the imaging plane in
15
increments should line the imaging plane with the pathway or
tunnel of the PFO. From this angle, the length of the PFO tunnel
can be assessed. The thickness of the septum secundum can also be
evaluated from this view.
With the PFO visualized, agitated saline contrast is injected to eval-
uate for right-to-left shunting, as described in the section on
Techniques, Standards, and Characterization Visualization of
Shunting: TTE and TEE. Provocative maneuvers such as the
Valsalva maneuver should be performed to transiently increase the
Table 4 Views for assessment of ASD by TEE
View Example Atrial septal anatomy Procedural assessment
Suggested multiplane
angles Esophageal position
Basal transverse SVC, superior aortic, RUPV Device relationship in
atrial roof
0
, 15
, 30
, 45
Mid- to upper
esophagus
Four-chamber Posterior and AV rims,
maximal ASD diameter
Device relationship
to AV valves
0
, 15
, 30
Mid-esophagus
Short-axis Posterior and aortic rims,
maximal ASD diameter
Device relationship
to AoV and posterior
atrial wall
30
, 45
, 60
, 75
Mid- to upper
esophagus
Bicaval IVC and SVC rims, maximal
ASD diameter
Device relationship
to RA roof/dome
90
, 105
, 120
Mid- to upper
esophagus and
deep transgastric
Long-axis Dome/roof of LA Device relationship
to LA dome/roof
120
, 135
, 150
Mid- to upper
esophagus
August 2015

RA pressure over the LA pressure. Sedated patients could have diffi-
culty performing an adequate Valsalva maneuver (see the section on
Techniques, Standards, and Characterization Visualization of
Shunting: TTE and TEE).
Important anatomic details of the atrial septum that should be eval-
uated because they can influence device candidacy and selection
include the location of the PFO (although, unlike secundum ASD,
the location of a PFO is fairly consistent in the anterior or superior
portion of the fossa ovalis), thickness and extent of septum secundum,
total length of the atrial septum, length of the PFO tunnel, size of the
PFO at the RA and LA ends, distance of the PFO from the venae
cavae, presence of ASA (see the section on Imaging of IAS and
Septal Defects: Atrial Septal Aneurysm), and presence of additional
atrial septal fenestrations or defects. As with ASD, partial anomalous
pulmonary venous connection should be excluded.
Real-time 3D (RT3D) TEE has been used to better define PFO var-
iations compared with 2D TEE.82
RT3D TEE has shown that the
shape of the PFO is elliptical, not circular, and that the flow area de-
creases traversing from the RA to the LA. As with secundum ASD, the
area of the PFO changes during the cardiac cycle and is larger during
ventricular systole than diastole.82
RT3D TEE has also been used for
procedural guidance of closure with en face views of the atrial septum
showing the relationship of the PFO and device with the surrounding
structures in the RA and LA139
(Figure 44).
Specific anatomic characteristics of a PFO should be evaluated
when deciding on device selection for PFO closure.140
Specifically,
the diameter of the fossa ovalis, length of the PFO tunnel, presence
and size of an ASA, thickness of the septum secundum, and
maximum size of the PFO during the cardiac cycle are all important
in appropriate patient selection for transcatheter closure. In one series,
Figure 31 TEE of small ostium secundum ASD (yellow arrow) at
the midesophageal aortic valve short-axis view from the mid-
esophagus. Ao, ascending aorta.
Figure 32 TEE of large ostium secundum ASD from midesopha-
geal AoV short-axis view. Short-axis view of ostium secundum
ASD. Note aortic rim (arrow). AV, aortic valve/aorta.
Figure 30 TEE demonstrating from the upper esophageal short-axis view demonstrating the right pulmonary veins at (A) 0
without
and (B) with color Doppler and (C) without and (D) with color Doppler at 60
. LIPV, left inferior pulmonary vein; LSPV, left superior
pulmonary vein; RIPV, right inferior pulmonary vein; RSPV, right superior pulmonary vein.
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Silvestry et al 937

using these parameters to choose from among four types of closure
devices resulted in an improved closure rate and a decreased inci-
dence of complications compared with the use of a single-device strat-
egy for all PFOs.140
Atrial Septal Aneurysm
An ASA is a redundancy or saccular deformity of the atrial septum
associated with increased mobility (Figures 7 and 10). An ASA is
defined as an excursion of 10 mm from the plane of the atrial
septum into the RA or LA or a combined excursion right and left
of 15 mm. M-mode can be used to document this motion when
the cursor can be aligned perpendicular to the plane of the septum
(Figure 45). A more detailed classification system (that has not been
widely clinically adopted) has divided ASAs into five groups based
on the excursion exclusively into the RA or LA, predominantly into
the RA or LA, or with equal excursion right and left.141
ASA has been associated with the presence of a PFO or ASD, an
increased size of a PFO, and an increased prevalence of cryptogenic
stroke and other embolic events. ASA has also been associated with
multiple septal fenestrations. TEE is a more sensitive method than
TTE for evaluation of an ASA. The presence and extent of an ASA
is a factor in device selection for PFO closure. A device can be chosen
that is relatively large to encompass and stabilize the atrial septum or a
smaller and softer device might be chosen for better conformation
with the ASA.
The excursion of the atrial septum can be documented using 2D
imaging, as well as M-mode assessment when the M-mode cursor
can be aligned perpendicular to the plane of the IAS. This can be
done in the subcostal four-chamber views on TTE, in the bicaval views
on TEE, and in the septal long-axis views on ICE (Figure 45).
Eustachian Valve and Chiari Network
The eustachian valve extends anteriorly from the IVC–RA junction
and is best visualized on TTE from the subxiphoid coronal and sagittal
views. On TEE, the eustachian valve is best visualized in the longitu-
dinal plane. The size of the eustachian valve and proximity to the IAS
geal modified bicaval view (includes the tricuspid valve). See
also Video 17.
Figure 36 Zoomed bicaval TEE view of thrombus (yellow arrow)
attached to the IAS at the left atrial septal pouch. This might
represent a thrombus in transit crossing a PFO (paradoxical em-
bolism) or an in situ thrombus in the left atrial septal pouch. SP,
septum primum; SS, septum secundum.
Figure 34 TEE of closure device in ostium secundum ASD from
midesophageal four-chamber view. Note relationship between
AV valves. Note ASD closure device (blue arrow).
geal four-chamber view. Note ASD (blue arrow).
August 2015

should be noted on the echocardiographic evaluation, because a large
eustachian valve that is close to the IAS can interfere in the deploy-
ment of the RA side of a closure device.
A Chiari network is a remnant of the right valve of the sinus ve-
nosus and appears as a filamentous structure in various places in the
RA, including near the mouth of the IVC and coronary sinus
(Figure 20). A Chiari network can interfere in the passage through
the RA of wires, catheters, sheaths, cables, and the device.
Therefore, the identification of the presence of a Chiari network
should be a part of the echocardiographic evaluation before device
closure of an ASD or a PFO.142
Assessment of ASDs: Standards and Characterization
ASDs represent a diverse group of differing anatomic lesions that all
result in intracardiac shunting. The types of ASDs and other interatrial
communications have been fully described in previous sections. The
common features of all ASD types that should be systematically eval-
uated and reported for all ASD types are listed in Table 7. These
include the type of ASD (primum or secundum) or other atrial
communication (venosus or unroofed coronary sinus), the presence
and direction of Doppler flow through the defect, and associated find-
ings such as anomalous pulmonary vein drainage, the presence and
size of an eustachian valve or a Chiari network, the size and shape
of the defect or defects, the location in the septum, the presence or
absence of multiple fenestrations, and the size of the ASD at end-
systole and end-diastole.
Ostium secundum ASD is the most common defect encountered
and most commonly occurs as a deficiency in septum primum.28
Secundum ASDs can vary considerably in their size, shape, and config-
uration, as has been described previously. A small ASD is typically
described as less than 5 mm in the maximal measured ASD diameter.143
With favorable anatomic features, ostium secundum ASDs can be
amenable to percutaneous transcatheter closure. This topic is specifically
reviewed later in the present document.30-33
Secundum ASDs have a
variable amount of surrounding tissue that borders the defect, and
these ‘‘rims’’ of surrounding tissue are named for the corresponding
surrounding adjacent anatomic structures. By convention, there are six
anatomically named rims of surrounding tissue. These rims should be
assessed carefully using echocardiography in all patients and, in
particular, before consideration of percutaneous closure. A rim length
of 5 mm or more is considered a favorable characteristic for
percutaneous transcatheter closure of a secundum ASD. An ASD rim
length of less than 5 mm is described as ‘‘deficient’’ and could present
challenges for transcatheter closure. Secundum ASD rims can be
defined as follows:
1. Aortic rim: the superior/anterior rim between the ASD and the AoV
annulus and aortic root
2. AV valve rim: the inferior/anterior rim between the ASD and the AV valves
3. SVC rim: the superior/posterior rim between the ASD and the SVC
4. IVC rim: the inferior/posterior rim between the ASD and the IVC
5. Posterior rim: the posterior rim between ASD and posterior atrial walls
6. Right upper pulmonary vein (RUPV) rim: the posterior rim between the
ASD and the RUPV
Having adequate superior, inferior, and anterior rims (SVC,
RUPV, IVC, and AV valve rims) is particularly important for success-
ful transcatheter ASD closure. A deficient aortic rim has been impli-
cated as a potential risk factor for erosion,103,104
although it might
not represent an absolute contraindication to device closure.
Erosion is discussed in greater detail in the section on Device
Embolization and Erosion. TEE evaluates these six ASD rims in
the upper esophageal short-axis, midesophageal short-axis, four-
chamber, and bicaval views, and TTE provides similar views. The
TEE views and corresponding rims evaluated are listed in Table 4.
Although TTE might be adequate for the evaluation of rims in
smaller pediatric patients, in larger pediatric and adult patients, it
will typically be inadequate. Therefore, TEE is recommended for
Figure 37 TEE demonstrating left pulmonary veins in two different views. Midesophageal views (A) without and (B) with color flow
Doppler obtained at 60
(mitral commissural view) with the probe then rotated slightly to the left to reveal the left-sided pulmonary
veins. Midesophageal long-axis views with the probe rotated toward the left pulmonary veins at 120
(C) without and (D) with color
Doppler.
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Silvestry et al 939

these patients to assess these rims before transcatheter closure. ICE
has been demonstrated to provide images of the ASD rims similar
to those with TEE, although no true four-chamber view is possible
with ICE. TEE with 3D imaging, if available, should be considered
for all patients under consideration for percutaneous closure—even
if an ICE-guided closure procedure is being planned.
Figure 38 Real-time 3D TEE images from the midesophageal short-axis views of a PFO during a saline contrast study. The PFO exit
into the LA is apparent (blue arrow). This is performed to help localize the site of bubble entry into the LA and not to quantify the size of
the shunt. (A–C) Progressive saline contrast microbubbles crossing through the PFO into the LA. Blue arrow indicates PFO tunnel.
See also Video 18.
Figure 39 Real-time 3D TEE images of an ostium secundum ASD from the (A) RA perspective demonstrating an ASD en face from the
midesophageal short-axis view, (B) RA perspective demonstrating the aortic rim (arrow) from the midesophageal short-axis view, and
(C) LA perspective from the four-chamber view also demonstrating the aortic rim. MV, mitral valve.
August 2015

KEY POINTS
TTE evaluation of a PFO, including the use of agitated saline contrast, is used to
identify the presence or absence of a PFO according to the presence of right-to-
left shunting.
Once a PFO has been identified, if catheter closure is being contemplated, a
detailed evaluation of the atrial septal anatomy should be performed using TEE
or ICE.
With the PFO in view, agitated saline contrast is injected to evaluate for right-to-left
shunting(seethesectiononTechniques,Standards,andCharacterizationVisualization
of Shunting: TTE and TEE). Provocative maneuvers such as the Valsalva maneuver
should be performed to transiently increase the RA pressure over the LA pressure.
Sedated patients might have difficulty performing an adequate Valsalva maneuver.
The anatomic details of the atrial septum when a PFO is present that should be
routinely evaluated include the location of the PFO, thickness and extent of septum
secundum, total length of the atrial septum, length of the PFO tunnel, size of the
PFO at the RA and LA ends, distance of the PFO from the venae cavae, presence
of an ASA, and presence of additional atrial septal fenestrations or defects.
An ASA is defined as excursion of 10 mm from the plane of the atrial septum into
the RA or LA or a combined excursion right and left of 15 mm.
The common features of all ASDs and other septal defect types that should be eval-
uated systematically are listed in Table 7.
Ostium secundum ASDs have six defined rims of tissue surrounding them (aortic,
AV valve, SVC, IVC, posterior, and RUPV).
A ostium secundum ASD rim of less than 5 mm is considered deficient for pur-
poses of transcatheter closure but does not represent an absolute contraindication
to the procedure.
ROLE OF ECHOCARDIOGRAPHY IN TRANSCATHETER
DEVICE CLOSURE
Echocardiography is commonly used for imaging guidance
during percutaneous transcatheter closure of ASDs and
PFOs.8,57,62,75,83,88,144-146
Real-time intraprocedural echocardiography
Figure 40 Still image depicting the two perpendicular 2D TEE planes (A and B) used to acquire a zoomed 3DE data set of the IAS (C).
The left side of the atrial septum is shown in the en face perspective visualized after a 90
up–down rotation (curved arrow) of the data
set (D). Image D can be cropped to remove the left half of the atrial septum (E) and when rotated 90
counterclockwise (curved arrow)
(F), the entire course of the crista terminalis from the SVC toward the IVC (arrows) can be visualized. Ao, aorta; AS, atrial septum; CS,
coronary sinus; CT, crista terminalis; FO, fossa ovalis; RAA, right atrial appendage.
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Silvestry et al 941

with TTE, TEE, 3D imaging, and ICE provides important incremental
information before, during, and after deployment of the device.
Although each modality has its own advantages and disadvantages,
echocardiographic augmentation of fluoroscopic imaging offers signifi-
cant information in patient selection, device selection, procedural guid-
ance, monitoring for complications, and assessment of the results.
Description of Available Transcatheter Devices and
Techniques
The American College of Cardiology/American Heart Association
guidelines have recommended ASD closure for patients with RA
and RV enlargement, regardless of symptoms (class I).147
Small
ASDs (i.e., an ASD diameter of less than 5 mm) with no evidence
of RV enlargement or pulmonary hypertension do not require
closure, because they are not considered significant enough to affect
the clinical course or hemodynamics of these individuals. Smaller
ASDs that are associated with paradoxical embolism or platypnea-
orthodeoxia can be considered for closure according to guideline rec-
ommendations (class IIa). The only absolute contraindication for ASD
closure pertains to patients with irreversible pulmonary hypertension
(pulmonary vascular resistance greater than 8 Woods units) and no
evidence of left-to-right shunting (class III).147
Sinus venosus and
ostium primum defects are not suitable for percutaneous device
closure because of poor anatomic and rim characteristics and the
lack of randomized controlled trial data supporting this approach.
The indications and contraindications to ASD and PFO closure are
listed in Table 8.
Numerous devices exist for percutaneous transcatheter closure of
ASDs and PFOs (Figure 46). However, no transcatheter closure de-
vice has yet been approved by the U.S. FDA for the percutaneous
transcatheter closure of PFOs. The two types of devices currently
approved in the United States for transcatheter closure of secundum
ASDs are the Helex (W.L. Gore, Newark, DE) and Amplatzer (St. Jude
Medical, Plymouth, MN) septal occluder devices (Figure 46). Only se-
cundum ASDs have been approved by the FDA to be treated with
these percutaneous transcatheter closure devices. Thus, patients
with sinus venosus and primum defects should be evaluated for sur-
gical repair, if appropriate.
The Helex occluder (W.L. Gore) is composed of expanded polyte-
trafluoroethylene patch material supported by a single nitinol wire
frame. The device bridges and eventually occludes the septal defect
as cells infiltrate and ultimately cover the expanded polytetrafluoro-
ethylene membrane. The Helex occluder (W.L. Gore) is not recom-
mended for closure of defects larger than 18 mm in diameter or
those in which the rim is absent over more than 25% of the circum-
ference of the defect.
The Amplatzer septal occluder (ASO) and Amplatzer multifenes-
trated ‘‘cribriform’’ septal occluder (St. Jude Medical) are double-disc
devices composed of nitinol mesh and polyester fabric. These
devices are designed to appose the septal wall on each side of the
defect, creating a platform for tissue ingrowth after implantation.
The ASO (St. Jude Medical) is a self-centering device with a waist
sized to fill the diameter of a single ASD. The narrow waist of the
cribriform device is specifically designed to allow placement through
the central defect of a fenestrated septum; the matched disc diame-
ters positioned on either side of the septum maximize coverage of
multiple fenestrations. The ASO (St. Jude Medical) is contraindi-
cated in patients in whom a deficiency (defined as less than
5 mm) of septal rim is present between the defect and the right pul-
monary vein, AV valve, or IVC. Although a deficiency of the aortic
rim is not considered an absolute contraindication to the use of the
Figure 41 The interatrial septum when viewed from the LA (left). The atrial septum should be oriented with the right upper pulmonic
vein at the 1-o’clock position. When displayed as viewed from the right atrium (right), the SVC should be located at the 11-o’clock
position. A, anterior; AS, atrial septum, Ao, aorta; L, left; LAA, left atrial appendage; P, posterior; R, right; S, superior.
August 2015

device, it has been suggested that this could increase the risk of de-
vice erosion.
A significant proportion of defects are associated with absent or
deficient aortic rims, and although erosion after ASD device closure
occurs most often in these patients, the great majority of these defects
can be successfully closed by a device without subsequent erosion.
The Helex septal occluders (W.L. Gore) and ASOs (St. Jude
Medical) are deployed using their unique delivery systems by way
Table 5 Intracardiac echocardiographic views for assessment of IAS
ICE view Example
Position of ICE
catheter
Anterior–posterior
flexion
Right–left
flexion Visualized structures
Home view Mid-RA Neutral Neutral RA, TV, RV, PV, RVOT, lower IAS
Septal view Mid-RA Posterior tilt Rightward tilt Inferior and superior IAS, septum
primum, septum secundum,
relationship to MV
Septal long-axis
or bicaval
Upper RA Posterior tilt Rightward tilt IAS, septum primum, septum
secundum, SVC
Septal short-axis Mid-RA, turn toward
tricuspid valve
Posterior tilt Leftward tilt AoV, IAS, posterior–anterior plane
of ASD, posterior and AV rims
MV, mitral valve; RVOT, right ventricular outflow tract; TV, tricuspid vale.
Table 6 Features of currently available intracardiac ultrasound systems
Ultrasound method/
name of catheter
Catheter
size (F)
Imaging frequency
range (MHz)
Viewing
sector (
)
Depth of
field (cm) Steering (
) Doppler RT3D available Cost
Rotational/UltraICE* 9 9 360 5 No No No +
Phased array/Viewflex
Plus†
9 4.5–8.5 90 21 Anterior–posterior (120) Yes No ++
Phased array/AcuNav‡
8 or 10 5–10 90 16 Anterior, posterior, left,
and right (160)
Yes Yes (10F catheter only) ++
*Boston Scientific, Natick, MA.
†
St. Jude Medical, St. Paul, MN.
‡
Siemens Medical Solutions USA, Inc., Malvern, PA.
Volume 28 Number 8
Silvestry et al 943

of venous access after careful assessment of the atrial septum and
sizing of the defect. The distinctions between techniques in device de-
livery and assessment of appropriate positioning are discussed in the
subsequent sections.
Device Embolization and Erosion
Complications of percutaneous PFO and ASD closure devices are
rare and include device embolization, cardiac perforation, tampo-
nade, and device erosion.148,149
Device embolization occurs in
approximately 0.1%–0.4% of cases and is most common with ASD
closure devices.149
Device embolization is a potential life-
threatening complication requiring immediate removal by percuta-
neous or surgical intervention. Device embolization can be readily
diagnosed by routine surveillance TTE. The risk factors for device
embolization include an undersized ASD device, deficient rims of sur-
rounding tissue, and device malpositioning. Immediate embolization
can occur after device deployment and most likely results from device
malpositioning or an incorrect device size. TTE and TEE are invalu-
able tools in evaluating the precise location of a dislodged device
and the physiologic sequelae (e.g., inflow/outflow obstruction, valve
disruption) that result from the embolization.
Figure 42 Intracardiac echocardiographic evaluation of the IAS (see the section on Intracardiac Echocardiographic Imaging Protocol
for IAS for details). (A) Home view. (B) Septal long-axis view. (C) Bicaval view. (D) Septal short-axis view of PFO. (E) Septal short-axis
view of ostium secundum ASD. The white arrow indicates the direction of PFO flow through stretched PFO. LAA, left atrial
appendage; RVOT, right ventricular outflow tract; TV, tricuspid valve. See also Video 19.
Figure 43 Intracardiac echocardiogram of an ostium secundum
ASD with left to right flow with and without color Doppler map-
ping. The white arrow indicates the direction of ASD flow; yellow
arrow, the aortic rim. AV, aortic valve.
Table 7 Specific characteristics of ASD that should be
routinely measured and reported
ASD type—PFO, primum ASD, secundum ASD, or other atrial
communication (sinus venosus defect, unroofed coronary
sinus, anomalous pulmonary vein drainage)
Doppler flow—presence of left to right, right to left or
bidirectional flow
Presence or absence of ASA
Associated findings—eustachian valve or Chiari network
ASD size—maximal and minimal diameters (optimally measured
from 3D volume data sets), ASD area
ASD location in septum (i.e., high secundum ASD, sinus venosus
defect SVC or IVC type)
Measurement of all rims—aortic, RUPV, superior, posterior,
inferior, AV septal
Shape of ASD—round, oval, irregular
Presence of multiple fenestrations
Dynamic nature of ASD—measurement of area and
maximum/minimal diameters in end-systole and
end-diastole
Stop-flow diameter of ASD (when balloon sizing is used for
percutaneous transcatheter closure)
August 2015

Device erosion is a rare but potentially fatal event. Erosion has
been reported to occur with multiple devices, including the ASO
(St. Jude Medical), the atrial septal defect occluder system, and
the Angel-Wings device (Microvena Corp., White Bear Lake, MN).
Of these, only the ASO (St. Jude Medical) is currently approved
for use in the United States.63,150,151
The estimated rate of erosion
with the ASO (St. Jude Medical) is 0.1%–0.3%.150,152-154
Device
erosion can occur at the roof of the RA or LA or at the junction
of the aorta and can result in hemopericardium, tamponade,
aortic fistula, and/or death.154
Device erosion can begin as a
Figure 44 Triplane (A, 3D; B, biplane orthogonal short-axis, and C, biplane orthogonal long-axis views) of cribriform closure device
deployed during PFO closure. The white arrow indicates LA disc of closure device. AV, aortic valve.
Figure 45 M-mode of an ASA demonstrating greater than 15 mm mobility of the fossa on ICE imaging.
Volume 28 Number 8
Silvestry et al 945

subclinical event, with the device impinging on the surrounding
structures, tenting the atrial or aortic tissue, or resulting in a subclin-
ical pericardial effusion. Erosion can also manifest clinically with
chest pain, syncope, shortness of breath, the development of a he-
mopericardium, cardiac tamponade, hemodynamic compromise,
and death.151,154
Most cases of erosion have been reported to occur within 72 hours
of device implantation, but late erosion cases have been reported
greater than 6 years after deployment.155
Most erosions occur in
the first week after implantation.63,151
Although not well defined, it
has been assumed that erosion is related to the abrasive mechanical
forces between the human tissue and the device (in contrast to
inflammation).
The cause of erosions is unknown. A thorough understanding of this
serious problem has been hampered by the infrequency of this compli-
cation and the absence of data from control populations. Extensive re-
views of imaging and device data from series of cases in which erosions
occurred have been performed. From such information and expert
consensus, the factors can be broadly divided into those generally
thought to be more significant such as device oversizing (present in
up to 40% cases), the complete absence of the aortic rim, a high/supe-
rior septal location of the defect, and a deficient anterior rim with
Figure 46 Examples of ASD closure devices. (A) ASO (St. Jude Medical). (B) Helex occluder (W.L. Gore). (C) Cartoon depicting
deployment of ASD device. 4C, four-chamber (view); Ao, aorta; SAX, short-axis (view).
Table 8 Indications and contraindications for ASD and PFO closure
Potential Indications for ASD and PFO closure
Isolated secundum ASD with a pulmonary/systemic flow (Qp/Qs) ratio 1.5:1, signs of right ventricular volume overload
PFO—cryptogenic stroke and evidence of right to left shunt (currently still under investigation and not FDA approved)
Contraindications (absolute or relative)
PFO or small ASD with Qp/Qs 1.5:1 or no signs of RV volume overload
A single defect too large for closure (38 mm)
Multiple ASDs unsuitable for percutaneous closure
Defect too close to SVC, IVC, pulmonary veins, AV valves, or coronary sinus
Anterior, posterior, superior, or inferior rim 5 mm
Abnormal pulmonary venous drainage
Associated congenital abnormality requiring cardiac surgery
ASD with severe pulmonary arterial hypertension and bidirectional or right-to-left shunting
Intracardiac thrombi diagnosed by echocardiography
August 2015

associated insufficiency of the posterior rim.154
Other morphologic risk
factors that have been proposed to predict erosion include a specific
ASD orientation such as malalignment of the defect with the aorta, a
dynamic ASD (one that changes size more than 50% throughout the
cardiac cycle), a deficient or an absent aortic rim (present in up to
90% of cases), and a device that straddles or splays around the aorta.154
No consensus has been reached, however, in the interventional com-
munity regarding the root cause of erosion.31,152
It is important to
note, for example, that a deficient aortic rim is prevalent among
populations of patients who have undergone successful device
closure of ASD with the ASO (St. Jude Medical) (40% in a recent
report).31,153,154
Important risk factors for erosion after device
placement have been suggested from a retrospective review of
available data on confirmed cases and include deformation of the
closure device at the aortic root and pericardial effusion seen within
24 hours of deployment. The proposed risk factors for erosion of the
Amplatzer device are listed in Table 9.
No one risk factor or echocardiographic feature therefore can
define the absolute risk of erosion. Thus, no clear ‘‘echocardiographic
contraindications’’ exist for device closure. In one conceptual frame-
work, for example, erosion might result from the unique combination
of certain specific high-risk ASD morphologic features that are then
combined with an oversized device and subsequent remodeling of
the heart and closure device. Echocardiographic imaging therefore
might help to identify patients at risk of erosion (e.g., aortic rim defi-
ciencies, device–patient mismatch at the atrial roof, or impingement
of the aorta before release).154
The FDA and the manufacturer
have concurred that an additional postapproval study of the ASO
(St. Jude Medical) would be beneficial to better evaluate the risk fac-
tors for erosion. A standardized rigorous protocol for the evaluation of
the atrial septum and associated rims, such as described in the present
document, has the potential to increase the quality and consistency of
the data used to analyze the root cause and prevent this rare, but
serious, complication.
Imaging Modalities in Transcatheter Guidance: TTE, TEE,
ICE
Regardless of modality, echocardiography is essential in the moni-
toring of transcatheter procedure guidance and postprocedural
complications. A comprehensive list of all potential complications
of transcatheter closure and the appropriate imaging modality to assist
with the diagnosis is provided in Table 10.
Table 9 Proposed possible risk factors for Amplatzer device
erosion
Deficient aortic rim in multiple views, absent aortic rim at 0
(‘‘bald
aorta’’)
Deficient superior rim in multiple views
Superior location of secundum ASD
Oversized ASD device (device diameter 1.5 times static
stop-flow diameter)
Dynamic ASD (50% change in size of ASD)
Use of 26-mm ASO device
Malaligned defect
Tenting of atrial septal free wall after placement of device
(into transverse sinus)
Wedging of device disc between posterior wall and aorta
Pericardial effusion present after device placement
Table
10
Acute
and
chronic
complications
of
percutaneous
transcatheter
closure
and
role
of
echocardiography
in
diagnosis
and
treatment
Complication
Consequence
Acuity
Treatment
Role
of
echocardiography
Preferred
echocardiographic
modality
Cardiac
perforation
Tamponade
Acute
Surgery
Diagnosis
TTE,
TEE,
or
ICE
Device
embolization
Embolization,
valve
obstruction
Acute
or
chronic
Percutaneous
or
surgical
retrieval
Diagnosis,
guidance
of
percutaneous
retrieval
TTE,
TEE,
or
ICE
for
diagnosis;
TEE
or
ICE
for
retrieval
Bleeding
Hypovolemia,
shock,
death
Acute
Transfusion,
surgical
intervention
Excluding
other
diagnoses
TTE
Pulmonary
embolism
Respiratory
failure,
death
Acute
Anticoagulation
Evaluating
for
right
heart
strain
TTE
Device
erosion
Hemopericardium,
tamponade,
death
Chronic
or
late
Surgical
Diagnosis
TTE
(effusion
or
hematoma);
TEE
(erosion)
Device
thrombosis
Embolism,
stroke
Chronic
or
late
Anticoagulation
Diagnosis
TEE
Infectious
endocarditis
Embolism,
sepsis,
abscess,
death
Chronic
or
late
Antibiotics,
surgery
Diagnosis
TEE
Device
fracture
Cardiac
erosion,
perforation,
shunt
Chronic
or
late
Surgical
exploration
Diagnosis
TEE
Volume 28 Number 8
Silvestry et al 947

Figure 47 Images representing three (of five) key views for assessment of ASD by TEE. Short-axis views are critical for the assess-
ment of the aortic rim and device interaction with the aorta. Bicaval and long-axis views (not shown) are critical for the assessment of
the relationship of the device with the roofs of the atrium. AV, atrioventricular valve rim; Post, posterior rim.
Figure 48 Three-dimensional TEE of medium size ostium secundum ASD with a mildly deficient aortic rim. (A) Midesophageal aortic
valve short-axis view demonstrating ASD and aortic rim deficiency. (B) Similar view demonstrating brisk left to right color Doppler
flow. (C) Zoom acquisition of ASD en face from RA perspective. White arrow indicates ASD. AV, aortic valve.
August 2015

Transthoracic echocardiography is the least invasive imaging mo-
dality for percutaneous transcatheter closure and could be adequate
for procedure guidance in smaller patients.62
Its limitations include
suboptimal imaging in larger patients and interference of the echocar-
diographic probe with fluoroscopy. In addition, the implanted device
creates artifacts, frequently precluding interrogation of the lower rim
of the atrial septal tissue above the IVC.
Transesophageal echocardiography provides detailed imaging find-
ings during percutaneous transcatheter closure.7,8,63,66,80,90,145
General anesthesia can be used when TEE is performed to enhance
patient comfort and reduce the aspiration risk. In addition to
anesthesia support personnel, a dedicated echocardiographer is
required to perform the TEE during the closure procedure.
Conscious sedation can also be used for selected cases.
Intracardiac echocardiography has emerged as an alternative, and
in some centers, the preferred, imaging modality for transcatheter
closure guidance.65,83,85,88,91,92,146,156
ICE offers imaging that is
comparable to TEE and superior to TEE with respect to LA
structures and the posterior–inferior rim of the septum. An
additional 8F–11F sheath is required for the intracardiac
echocardiographic system. If the patient’s weight is more than
35 kg, the sheaths for both the device delivery and the ICE systems
can be placed in the same femoral vein using two separate
punctures several millimeters from each other. In smaller patients,
venous access for the ICE catheter should be obtained in the
contralateral vein. Although separate echocardiographic expertise is
often used to provide assistance during the procedure, it is not
required, because the interventionalist performing the septal closure
can also manipulate the catheter. Its advantages include avoidance
of general anesthesia, shorter procedure and fluoroscopy times, and
comparable or lower cost to TEE-guided percutaneous closure
when general anesthesia is used for those undergoing TEE-guided
closure.65,83,90,146
Three-dimensional ICE has been recently intro-
duced, and the preliminary results reported from evaluating patients
with structural heart disease are beginning to emerge.95,97
Three-dimensional TEE offers RT3D imaging of the atrial septum,
providing a comprehensive analysis of the defect and its relationship
to the surrounding structures. Direct visualization of the deployed
device from both atria augment the postdeployment assessment
of the efficacy and potential complications associated with the
procedure.6,7,31,63,65
Intraprocedural Guidance of Transcatheter Interventions
All patients undergoing percutaneous transcatheter closure of septal
defects require preprocedural echocardiographic imaging with
either TTE or TEE, as outlined, to comprehensively assess the septal
anatomy and determine the suitability of an atrial defect for device
closure. This includes a thorough echocardiographic investigation of
the entire IAS and surrounding structures using multiple sequential
planes, as previously defined. The type of defect (ASD type, ASA,
PFO, stretched PFO) and the number of defects (up to 13% of pa-
tients could have more than one defect), defect size, location,
morphology, and the surrounding atrial septal tissue (rims) should
be defined (Table 7). Any associated abnormalities of the surround-
ing structures such as the pulmonary veins, IVC, SVC, coronary
sinus, eustachian valve, and AV valves should be characterized or
excluded.
The IAS defect and surrounding rims of atrial tissue should be
carefully and thoroughly interrogated. Using TEE with the mid-
esophageal four-chamber view (starting from 0
multiplane and
moving in 15
multiplane increments), the inferior–anterior and
Figure 49 Three-dimensional TEE of medium size ostium secundum ASD with a deficient aortic rim. (A) Modified midesophageal
four-chamber view. (B) Biplane image demonstrating multiple areas of deficiency. (C) Zoom acquisition of ASD en face from LA
perspective. Yellow arrow indicates a deficient rim; white arrow, ASD. AV, aortic valve. See also Videos 20 and 21.
Volume 28 Number 8
Silvestry et al 949

superior–posterior rims can be defined (Figures 47–49). The
anterior (retro-aortic) and posterior rims are measured in the
midesophageal AoV short-axis view (starting at 30
–45
multiplane
and moving in 15
increments). The midesophageal bicaval view
(110
–130
) is used to most clearly visualize the superior and infe-
rior rims. Imaging with 3D echocardiography allows for acquisition
of similar sets of data but without the need for serial assessment in
multiple stepwise views (Figures 50 and 51). Transgastric imaging
could be required to visualize the inferior rim of an ASD in some
cases and can be used to define the relationship of the inferior
aspects of the device and the IAS.
ICE Guidance of PTC
When using ICE guidance, a full assessment of the defect and surround-
ing tissue rims should be performed. The probe is initially positioned
such that the tricuspid valve is identified. From this position, a posterior
deflectionof theposterior/anterior knob with a slight rightward rotation
of the right–left knob will obtain the septal view (Figures 42C, 43).
Advancing the catheter cephalad produces the bicaval view, from
which thesuperiorand inferior rimsand the defect diameterand config-
uration are measured (Figure 52A). Rotation of the entire handle clock-
wise until the intracardiac transducer is near the tricuspid valve,
followed by a slight leftward rotation of the right–left knob until the
AoV appears creates a view similar to the TEE short-axis plane, with
the difference being the near field with ICE is the RA versus that with
TEE showing the LA (Figure 52B). From this view, the diameter of
the defect and the aortic and posterior rims can be measured.
A complete ‘‘neutral’’ sweep should be performed starting at the
‘‘home view’’ and ending back at the home view. This will, in many
instances, effectively exclude sinus venosus SVC-type ASDs, evaluate
any AV valve regurgitation, and provide a comprehensive overview of
Figure 50 Representative views and anatomic landmarks in an ostium secundum ASD. (A) RA and LA en face views. (B) Another
example of RA and LA en face views. (C) Transgastric sagittal bicaval view acquired in live 3D mode from the standard perspective
(left) and posterior perspective (right). (D) Posterior aspect views demonstrating the variable alignment between the septum primum
and septum secundum over the cardiac cycle. (Left) Alignment between the septum secundum and septum primum (arrow) compo-
nents. Mild malalignment (middle) and more malalignment (right) present between the septal components. As the malalignment in-
creases, the size of the interatrial communication (asterisk) increases. In the orientation icon, blue designates the y plane, red, the x
plane, and green, the z plane. A, anterior; Ao, aorta; C, catheter; CS, coronary sinus; L, left; LPV, left pulmonary vein; P, posterior; R,
right; RAA, right atrial appendage; RPA, right pulmonary artery; S, superior; S1, septum primum; S2, septum secundum; TV, tricuspid
valve. Reproduced with permission from Roberson et al.72
August 2015

the atrial septum. This should be performed before and after device
placement, again to evaluate for mitral regurgitation and tricuspid
regurgitation after device placement. A full sweep both of the bicaval
and AoV views usually can be done with the catheter having a poste-
rior tilt and pointing directly anterior in the RA.
The initial echocardiographic assessment should include measure-
ment of the defect diameter in the orthogonal planes, overall septal
length, and defect rims (retro-aortic, inferior–IVC, and posterior–pul-
monary vein). If multiple defects are present, each should be charac-
terized and the distance separating them measured.
In addition to echocardiographic data, a thorough right and left
heart hemodynamic assessment is performed to determine the phys-
iologic significance of the defect and exclude any anatomic or physi-
ologic contraindications to septal closure. Right upper pulmonary
venous angiography (35
left anterior oblique with 35
cranial angu-
lation) can be performed to profile the atrial septum and serve as a
fluoroscopic road map during device deployment.
Balloon sizing of the defect with fluoroscopic and echocardio-
graphic imaging is recommended for all ASD device closure cases;
however, some operators might choose not to perform balloon
sizing owing to the dimensions of the defect. The stop-flow tech-
nique involves placement of a sizing balloon (St. Jude sizing balloon,
St. Jude Medical; or NuMED sizing balloon, NuMED Inc.,
Hopkinton, NY) across the interatrial defect. During imaging with
color Doppler, slow inflation of the balloon is performed until color
flow across the defect has completely ceased (Figure 53A). The
diameter of the balloon within the atrial septum is measured in
several imaging planes at the point at which flow across the defect
has been eliminated. In addition, it is essential to interrogate the
septum during balloon occlusion of the defect in two orthogonal
views (short axis and bicaval) to identify or exclude the presence
of additional defects.
Once sizing has been completed, the ICE catheter is moved
back to the long axis to monitor the various steps of closure
(Figure 53B–E).
Imaging the IAS Immediately After the Procedure
Echocardiographic guidance during deployment of both the ASO
(St. Jude Medical) and the Helex (W.L. Gore) septal occlusion de-
vices is used to monitor all stages of device delivery. The most useful
views with TEE are the four-chamber and short-axis views. With
ICE, the bicaval view gives a panoramic image of the entire LA
(Figure 53).
For the ASO (St. Jude Medical), a device between the stop-flow
diameter and up to 2 mm greater is typically selected. The delivery
system is introduced through the venous sheath and advanced into
the left upper pulmonary vein (Figures 52 and 53). The wire and
the dilator are slowly withdrawn, taking care to eliminate the
possibility of air embolism. The device is loaded and advanced to
Figure 51 Three-dimensional TEE facilitates en face assessment of ASD shape and size and can characterize the degree of defi-
ciency of the rims. The aortic rim is shown to be deficient in the bottom center image slice.
Volume 28 Number 8
Silvestry et al 951

Figure 52 Intracardiac echocardiographically guided ASD closure of ostium secundum defect. (A and B) Preprocedure images
demonstrating ostium secundum ASD. Yellow arrow indicates ASD. (C) Passage of guidewire into left superior pulmonary vein.
(D) Passage of guide catheter into LA. DTA, descending thoracic aorta. See also Videos 22 and 23.
Figure 53 Intracardiac echocardiographically guided ASD closure of ostium secundum defect. (A) Balloon sizing of the defect with
and without color Doppler. Arrow indicates a small degree of flow around the sizing balloon. (B) Left atrial disc opens and is withdrawn
to the interatrial septum. (C) Withdrawal of the LA disc toward the IAS. (D and E) Both discs are opened and the position is checked
carefully to ensure the septum is ‘‘sandwiched’’ between the discs. See also Videos 24–28. Video 28 represents a sweep through the
ASD resulting in an en face view of a stable device.
August 2015

the tip of the sheath. The delivery sheath is then repositioned into the
body of the LA from the pulmonary vein. The interventionalist fixes
the cable and retracts the sheath, thus deploying the LA disc
(Figure 53B). It is critical that echocardiography demonstrates to the
operator at this stage that the LA disc is remote from the pulmonary
veins or LA appendage. Once the left disc is within a few millimeters
from the septum, the connecting waist is deployed partially in the LA
with continuous traction toward the defect (Figure 53C). The objec-
tive is to ‘‘stent’’ the defect with the waist. Next, with continuous trac-
tion toward the RA, the RA disc is deployed (Figure 53D and E). Once
the entire disc is free of the sheath, the delivery cable is advanced to-
ward the septum to bring the two discs of the device into approxima-
tion (Figure 53E).
For the Helex septal occluder (W.L. Gore), the ratio of the device
to defect diameter should exceed 2:1, and the selected diameter of
the device should be no more than 90% of the measured septal
length. Under fluoroscopic and echocardiographic visualization,
the catheter tip of the Helex delivery system (W.L. Gore) is
advanced across the ASD until the radiopaque marker is positioned
within the LA. The left atrial occluder disc is formed in the body of
the LA. The interventionalist relies primarily on fluoroscopic imag-
ing for this maneuver. If TEE is being used, it might be beneficial
to pull the probe back out of the fluoroscopic field. Once the LA
disc has been formed, echocardiographic imaging is used to guide
the positioning of the device against the LA aspect of the septum.
The LA disc is fixed against the septum while the delivery catheter
is withdrawn into the RA and the RA disc is formed.
Echocardiographic assessment is performed to confirm that both
right and left discs appear planar and apposed to the septum with
septal tissue between the discs.
For both the Helex (W.L. Gore) and the ASO (St. Jude Medical) de-
vices, a complete assessment of the device, atrial septum, and sur-
rounding structures is performed before release of the device. Two
orthogonal views are obtained to verify that the LA and RA discs
are located in the correct chamber. Color Doppler interrogation is
performed to exclude residual flow at the device margins, the pres-
ence of which suggests inappropriate device size or position
(Figure 54). Careful imaging is performed to identify the presence
of atrial septal tissue between the LA and RA device discs.
Although the aortic rim is generally easily seen, care must be taken
to identify the presence of posterior and inferior tissue. Interference
with the pulmonary veins, coronary sinus, AV valve function, and
deformation of the aortic root are carefully assessed and excluded
before release. Possible device interaction with the aorta and sur-
rounding tissues should be noted. After release of the device, the iden-
tical assessments should be performed again. The role of 3D ICE has
not yet been clearly defined, but it offers potential for additional
anatomic delineation at the transcatheter closure (Figure 55).97
Follow-Up
A TTE study should be performed before hospital discharge (and
repeated in 1 week when the Amplatzer device has been used).
Attention should be given to the device position, any residual shunt,
and any evidence of erosion, device instability, or deformation of the
surrounding structures. The presence of a pericardial effusion of even
modest size could be an indication of device erosion. A 12-lead elec-
trocardiography study should also be performed because rare cases of
heart block have been reported with large devices.157,158
An
increased incidence of atrial arrhythmias and conduction
abnormalities early after device closure has been reported.158
Follow-up evaluations, including TTE, should be performed at 1, 6,
and 12 months after the procedure, with a subsequent evaluation every
1–2 years. For the Helex septal occluder (W.L. Gore), attention should
also be given toward the stability of the device, because a lack of device
stability could indicate wire frame fractures. In instances in which de-
vice stability is questionable, fluoroscopic examination without contrast
is recommended to identify and assess wire frame fractures. The RV
size will typically improve rapidly in the first month after termination
of the left-to-right shunt; however, long-standing RV dilation might
improve more slowly and also might not normalize completely.159
KEY POINTS
TTE is the least invasive imaging modality for percutaneous transcatheter closure
and might be adequate for procedure guidance in smaller patients.
TEE provides detailed imaging during percutaneous transcatheter closure.
ICE has emerged as an alternative to TEE and, in some centers, is the preferred im-
aging modality for transcatheter closure guidance.
3D TEE offers RT3D imaging of the atrial septum, providing a comprehensive anal-
ysis of the defect and its relationship to surrounding structures.
Regardless of modality used, a complete assessment of the defect and surrounding
tissue rims should be performed (Table 7).
Balloon sizing of the ASD is recommended before closure. During imaging with
color Doppler, slow inflation of the balloon is performed until the color flow across
the defect has completely ceased. The diameter of the balloon within the atrial
septum is measured in several imaging planes at the point at which the flow across
the defect has been eliminated.
A complete assessment of the closure device, atrial septum, and surrounding struc-
tures should be performed before release of the device.
Careful imaging should be performed to identify the presence of atrial septal tissue
between the LA and RA device discs. Although the aortic rim is generally easily
seen, care must be taken to identify the presence of posterior and inferior tissue.
TTE should be performed on all patients before hospital discharge (and repeated in
1 week when the ASO device has been used).
Follow-up evaluations with TTE should be performed at 1, 6, and 12 months after
the procedure, with a subsequent evaluation every 1–2 years.
CONCLUSION
As presented in the present document, a comprehensive systematic
echocardiographic evaluation of the atrial septal anatomy and associ-
ated abnormalities includes the detection and quantification of the
Figure 54 Intracardiac echocardiographically guided ASD
closure of ostium secundum defect. See the section on Imaging
the IAS Immediately After the Procedure for details. The final po-
sition of device (after release from guiding cable) demonstrating
normal small residual leak (arrows) through the device (before
thrombosis and endothelialization).
Volume 28 Number 8
Silvestry et al 953

size and shape of all defects, the rims of tissue surrounding the defect,
the degree and direction of shunting, and the remodeling and changes
in size and function of the cardiac chambers and pulmonary circula-
tion. This requires integration of findings across TTE, TEE, and/or
ICE imaging for the complete assessment of patients with atrial septal
abnormalities. A standardized imaging approach and nomenclature
has been presented in the present document to facilitate the compre-
hensive assessment of these abnormalities.
The emergence of 3D visualization and characterization of
normal and abnormal septal anatomy has contributed significantly
to the evaluation of the IAS and percutaneous and surgical thera-
peutic intervention. Future imaging directions include continued
refinement of 3D imaging techniques across all modalities (TTE,
TEE, ICE), fusion of echocardiography with other imaging modal-
ities such as cardiac computed tomography and fluoroscopy for
guidance of transcatheter closure, additional refinement of the
methodology in the assessment and quantification of interatrial
shunting, and additional delineation of the pathophysiologic rela-
tionship of PFO with cryptogenic stroke. Imaging has the potential
to contribute to and enhance the understanding of factors that
lead to successful device implantation and the risk factors for
erosion and device embolization.
NOTICE AND DISCLAIMER
This report is made available by the ASE and the Society for Cardiac
Angiography and Intervention (SCAI) as a courtesy reference source
for members. This report contains recommendations only and should
not be used as the sole basis of medical practice decisions or for disci-
plinary action against any employee. The statements and recommen-
dations contained in this report were primarily based on the opinions
of experts, rather than on scientifically verified data. ASE and SCAI
make no express or implied warranties regarding the completeness
or accuracy of the information in this report, including the warranty
of merchantability or fitness for a particular purpose. In no event shall
ASE or SCAI be liable to you, your patients, or any other third parties
for any decision made or action taken by you or such other parties in
reliance on this information. Nor does your use of this information
constitute the offering of medical advice by ASE or SCAI or create
any physician–patient relationship between ASE or SCAI and your
patients or anyone else.
SUPPLEMENTARY DATA
Supplementary data related to this article can be found at http://dx.
doi.org/10.1016/j.echo.2015.05.015.
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