This document provides a summary of key trends related to vaccination. It discusses how vaccine hesitancy has increased around the world in recent decades, potentially undermining public health efforts to respond to the COVID-19 pandemic. Employers have an important role to play in encouraging vaccination and responsible behavior during pandemics in order to protect public health and enable businesses and the economy to return to normal. However, the spread of misinformation about health issues and vaccines has undermined trust and compliance with public health recommendations. As research on a COVID-19 vaccine continues, effectively countering misinformation will be important for building confidence in any potential vaccine.