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Skin Cancer
             Diagnosis and
             Management


Dr Rob Paver
Medical Director
Skin and Cancer Foundation Westmead
Skin Cancer Statistics
Skin Cancer accounts for more than 80% of newly
diagnosed cancer in Australia

2 out of 3 Australians will be diagnosed with skin
cancer in their lifetime     (DHA 2010)

GP’s in Australia have about 1 million patient
consultations per year for skin cancer related
concerns

Australia’s incidence of skin cancer is the highest in
the world and nearly 4 times the rate of Canada, USA
and UK
         (Australian Institute of Health and Welfare Cancer in Australia 2001)
Non Melanoma Skin Cancer
More than 430,000 patients are treated each year
for non melanoma skin cancer
296000 BCC     138000 SCC           (2008)

More than 400 die of NMSC per year(2008)

Skin cancer is our most expensive cancer

NMSC cost the government $264,000,000 in 2001

Melanoma cost $30,000,000 in 2001 (more now)
            (Australian Institute of Health and Welfare Cancer in Australia
2001)
Non Melanoma Skin Cancer

Actinic Keratoses
Basal Cell Carcinoma
Squamous Cell Carcinoma
Benign Differential Diagnoses
Treatment Options
Actinic Keratoses
Macular – telangiectatic
Papular – keratotic
Hypertrophic – hyperkeratotic
Cutaneous Horn
Single, few or multiple
Actinic Keratoses
Multiple Macular              Single Papular




                              Cutaneous Horn
 Hypertrophic
Actinic Keratoses



       Keratotic      Actinic Cheilitis




Diffuse Macular     Diffuse Inflammatory
Differential diagnoses of Actinic
Keratoses – Seborrhoeic Warts



    Verrucal           Standard




    Superficial         Skin Tags
Differential diagnoses of Actinic
Keratoses – Seborrhoeic Warts



    Verrucal            Lichenoid




    Macular             Multiple
Differential diagnoses of Actinic
            Keratoses



Bowens Disease          Superficial BCC’s




Actinic Porokeratoses   Lupus Erythematosus
Differential diagnoses of Actinic
            Keratoses




                          Stucco Keratoses


 Seborrhoeic Dermatitis
Treatment Options for Actinic
          Keratoses
Cryotherapy
Solaraze
Efudix
Aldara
PDT
Chemical Peel
Laser resurfacing
Curettage and cautery
Excision
Cryotherapy
Solaraze (3%Diclofenac gel)
Apply bd for 2 to 3 months
Cease for a week if too inflamed

Adverse effects - local irritation
             - like NSAID: bleeding etc
Efficacy - less effective than Efudix but
may have less noticeable inflammation
Efudix bd for 3 weeks
Aldara for Solar Keratoses
Dose: 3x per week for up to 16 weeks with
1 week holidays from Rx for severe
inflammation
Always titrate the duration of treatment
against the severity of response
Adverse effects: local inflammation,
hypopigmentation, headache and flu like
illness
Efficacy: longer lasting response than
efudix/solaraze, but higher cost and
variable response
Aldara
PDT
Good field treatment
Painful
More expensive
Need special
equipment
Resurfacing / Chemical Peel
Basal Cell Carcinoma
Superficial Multifocal
Nodular
Noduloulcerative
Micronodular
Pigmented
Morphoeic
Infiltrative
Recurrent
Superficial - Basal Cell Carcinoma
Nodular – Basal Cell Carcinoma
Ulcerative - Basal Cell Carcinoma
Pigmented and Micronodular BCC
Morphoeic - Basal Cell Carcinoma
Infiltrating - Basal Cell Carcinoma
Recurrent - Basal Cell Carcinoma
Recurrent - Basal Cell Carcinoma
Differential Diagnoses of BCC
  Dermal Nevus
                              Bowens




  Granuloma Annulare   Syringomas
Differential Diagnoses of BCC
 Nevus Sebaceous        Dermatofibroma

                           Dermatofibroma




  Amyloidosis      Sebaceous Hyperplasia
Differential Diagnoses of BCC



       Achrocordon                SCC


                            Amelanotic Melanoma
Minimally Pigmented Nevus
BCC Treatment Options
Cryotherapy
Curettage and Cautery
Aldara
PDT
Excision
Radiation Therapy
Mohs Surgery
Cryotherapy
Curettage and Cautery
Aldara (Imiquimod)
Primary Superficial BCCs
5x per week for 6 weeks
Treatment Holidays if too inflammatory
80% cure rate
Aldara – Before, During, After
This is presentation is continued in the next
 file…

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