Django is a Python-based MVC web framework. It follows an MTV pattern where the Model represents the business logic and database, the Template displays data, and the View connects Models and Templates by handling requests and returning responses. The presentation discusses why use Python and Django, what MVC is, and each component of MTV in Django - Models define database schemas, Views handle requests and return responses using Templates, and the framework handles common tasks like authentication, internationalization, and more. It also introduces Django Admin which automatically generates interfaces to manage database objects.