This study evaluates the effect of the YMCA High School Youth Institute on the academic performance of urban high school students, particularly focusing on low-income youth. Participants in the program showed significantly higher standardized test scores and GPAs compared to a matched comparison group, suggesting that high-quality out-of-school programs can effectively enhance academic achievement. The findings underscore the importance of such programs in addressing educational disparities faced by low-income youth and provide insights for future educational practices.