ACUPUNCTURE
IN PALLIATIVE CARE
EVIDENCE BASED MEDICINE
Sara Bowling, MD
Family Medicine and Medical Acupuncture
Family Care Network
INTEGRATIVE MEDICINE
CONVENTIONAL CARE
Symptom A
Symptom D
Symptom C
Symptom B
THE PILL BURDEN
Average elderly patient is on 8-13 medications
Anorexia
Anxiety
Constipation
Delirium
Depression
Diarrhea
SYMPTOMS IN END OF LIFE
Dyspnea
Fatigue
Nausea andVomiting
Pain
Respiratory tract secretions
Dexamethasone
Diazepam and Lorazepam
Docusate and Senna
Haloperidol
Amitriptyline and
Fluoxetine
WORLD HEALTH ORGANIZATION
ESSENTIAL MEDICATIONS LIST FOR PALLIATIVE CARE
Loperamide
Morphine
Metoclopramide
Ibuprofen
Hyoscine butyl-bromide
Dexamethasone - A
Diazepam/ Lorazepam- D
Docusate and Senna-D
Haloperidol - A
Amitriptyline and
Fluoxetine
EVIDENCE BEHIND MEDICATIONS
Loperamide - D
Morphine - A
Metoclopramide
Ibuprofen
Hyoscine butyl-bromide
SIDE EFFECTS
Dexamethasone
Anaphylactic reactions, acute
myopathy, perineal irritation,
psychiatric disturbances
Haloperidol
QT prolongation, anticholinergic
effects, leukopenia, CNS depression,
extrapyramidal symptoms, esophageal
dysmotility, orthostatic hypotension
Morphine
Constipation, CNS
depression, hypotension,
hypersensitivity reaction,
respiratory depression
ACUPUNCTURE
SAFE & EFFECTIVE
ACUPUNCTURE
IS SAFE
Rare Adverse Events
Dizziness
Subcutaneous bleeding
Mild burn
ACUPUNCTURE IS SAFE
Special Considerations
Never placed in tumor or ulcerated area
Never placed in limbs prone to lymphedema
Care when treating over chest wall in cachectic patients
No electroacupuncture if pacemaker
IS ACUPUNCTURE PAINFUL?
WHAT IS
ACUPUNCTURE?
Originated 2000 years ago
North America in the 1970s
as useful for anesthesia
A series of meridians through
which energy ïŹ‚ows
THE SCIENCE OF ACUPUNCTURE?
Acupuncture sara bowling may2016 pci conference
PAIN MODULATION
ENDOGENOUS OPIOIDS
Stimulates release of dynorphin,
enkephalin, beta-endorphin.
Increases endogenous
cannabinoid receptors
Up-regulates opioids in inïŹ‚amed
tissues
ENDOGENOUS OPIOIDS
Opioid antagonists such as naloxone, can reverse the analgesic
effects of acupuncture.
NATIONAL INSTITUTE OF HEALTH
CONSENSUS STATEMENT, 1997
“Acupuncture is an effective treatment modality for adult
postoperative and chemotherapy nausea and vomiting.”
“There is sufïŹcient evidence of acupuncture’s value to
expand its use into conventional medicine and encourage
further studies of its physiology and clinical value”
ACUPUNCTURE IS
EVIDENCE BASED MEDICINE
Research / DataClinical Expertise
PatientValues
& Expectations
The challenges of the acupuncture control:
SHAM acupuncture
SYSTEMATIC REVIEWS
Fatigue*
Nausea-Vomiting**
Pain*
Hot ïŹ‚ashes*
Xerostomia
Dyspnea
Anxiety
Anorexia
Constipation
Paresthesia
Insomnia
Limb edema
WHO’S 3- STEP LADDER FOR
CANCER PAIN RELIEF
PAIN
PAIN
NAUSE ANDVOMITING
FATIGUE
HOT FLASHES
INTEGRATIVE
EVIDENCE BASED MEDICINE
Research / DataClinical Expertise
PatientValues
& Expectations
Acupuncture is effective for
Pain control
Nausea and vomiting
Fatigue
Hot ïŹ‚ashes
It is best used alongside conventional medicine early on
in treatment, rather than as last resort
Alimi D, Rubino C, Pichard-Leandri E. et al.Analgesic Effect of Auricular Acupuncture for Cancer Pain:A Rondomized,
Blinded, Controlled Trial. J Clin Oncol. 2003; 21: 4120-6
Bardia A, Barton DL, Prokop LJ et al. EfïŹcacy of complementary and alternative medicine therapies in relieving
cancer pain: a systematic review. J Clin Oncol 2006; 24: 5457-5464
Langevin H,Yandow J. Relationship of Acupuncture Points and Meridians to Connective Tissue Plans. The Anatomical
Record 2002: 269: 257-265.
Lau C,Wu X, ChungV. et al. Acupuncture and Related Therapies for Symptom Management in Palliative Cancer Care:
Systematic Review and Meta-analysis. 2016: 95: 2901
Lee H, Schmidt K, Ernst E.Acupuncture for the relief of cancer-related pain: a systematic review. Eur J Pain 2005; 9:
437-444.
Lesi G, Razzini G, Musti M, et al.Acupuncture As an Integrative Approach for the Treatment of Hot Flashes in Women
with Breast Cancer:A prospective Multicenter Randomized Control Trial. Journal of Clin Oncology 2016; 2893.
Mao JJ, Xie SX, Farrar JT, et.al.A Randomised trial of electro-acupuncture for arthralgia related to amromitase
inhibitor use. Euro J Cancer. 2014; 50: 267-76
McCarthy L, Dolovich L, Haq M. et al. Frequency of risk factors that potentially increase harm from medications in
older adults receiving primary care. Can J Clin Pharmacol. 2007:14; 283-90
Mehling WE, Jacobs B,Acree M, et. al. Symptom Management with massage and acupuncture in postoperative cancer
patietns: a randomized controlled trial. J Pain Symptom Manage. 2007; 33: 258-66
Molassiotis A, Bardy J, Finnegan-John J, et. al.Acupuncture for cancer-related fatigue in patients with breast cancer: a
pragmatic randomized controlled trial. J Clin Oncol. 2012; 30: 4470-6.
Quin MX, Xi CY, Zhou H. Observation on effect of acupoint injection for treatment of morphine induced
constipation. J Qiqihar Med Coll. 2010: 31:3921.
Rostock M, Jaroslawski K, Guethlin C. Chemotherapy induced, peripheral neuropathy in cancer patients: a four arm
randomized trial on the effectiveness of acupuncture. Evid Based Complement Alternat Med. 2013; 349653.
Shen J,Wegner N, Glaspy J. et al. Electroacupuncutre for control of myeloablative chemotherapy-induced emesis: a
randomized controlled tiral. JAMA 2000; 284: 2755-61
Smith C, Carmady B,Thornton C, et al.The effect of acupuncture on post-cancer fatigue and well-being for women
recovering from breast cancer: a pilot randomized controlled tiral.Acupunct Med. 2013;31:9-15.
Tang WR, Chen WJ,Yu CT, et al. Effects of acupressure on fatigue of lung cancer patients undergoing chemotherapy:
an experimental pilot study. ComplementTher Med. 2014; 22: 581-591
Tao W, JIang H,Tao X. et al. Effects of Acupuncture,Tuina,Tai Chi, Qigong, and Traditional Chinese Medicine Five-
Element Music Therapy on Symptom Management and Quality of Life for Cancer Patients:A Meta-analysis. J Pain
Symptom Manage. 2016 51; 728-47
Towler P, Molassiotis A, Brearley SG.What is the evidence for use of acupuncture as an intervention for symptom
management in cancer supportive and palliative care: an integrative overview of reviews. Support Care Cancer 2013:
21:2913-2923
ZengY, Luo T, Finnegan-John J, et al. Meta-analysis of randomized controlled trials of acupuncture for cancer-related
fatigue. Integr CancerTher 2013; 13: 193-200

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Acupuncture sara bowling may2016 pci conference

  • 1. ACUPUNCTURE IN PALLIATIVE CARE EVIDENCE BASED MEDICINE Sara Bowling, MD Family Medicine and Medical Acupuncture Family Care Network
  • 5. THE PILL BURDEN Average elderly patient is on 8-13 medications
  • 6. Anorexia Anxiety Constipation Delirium Depression Diarrhea SYMPTOMS IN END OF LIFE Dyspnea Fatigue Nausea andVomiting Pain Respiratory tract secretions
  • 7. Dexamethasone Diazepam and Lorazepam Docusate and Senna Haloperidol Amitriptyline and Fluoxetine WORLD HEALTH ORGANIZATION ESSENTIAL MEDICATIONS LIST FOR PALLIATIVE CARE Loperamide Morphine Metoclopramide Ibuprofen Hyoscine butyl-bromide
  • 8. Dexamethasone - A Diazepam/ Lorazepam- D Docusate and Senna-D Haloperidol - A Amitriptyline and Fluoxetine EVIDENCE BEHIND MEDICATIONS Loperamide - D Morphine - A Metoclopramide Ibuprofen Hyoscine butyl-bromide
  • 9. SIDE EFFECTS Dexamethasone Anaphylactic reactions, acute myopathy, perineal irritation, psychiatric disturbances Haloperidol QT prolongation, anticholinergic effects, leukopenia, CNS depression, extrapyramidal symptoms, esophageal dysmotility, orthostatic hypotension Morphine Constipation, CNS depression, hypotension, hypersensitivity reaction, respiratory depression
  • 11. ACUPUNCTURE IS SAFE Rare Adverse Events Dizziness Subcutaneous bleeding Mild burn
  • 12. ACUPUNCTURE IS SAFE Special Considerations Never placed in tumor or ulcerated area Never placed in limbs prone to lymphedema Care when treating over chest wall in cachectic patients No electroacupuncture if pacemaker
  • 14. WHAT IS ACUPUNCTURE? Originated 2000 years ago North America in the 1970s as useful for anesthesia A series of meridians through which energy ïŹ‚ows
  • 15. THE SCIENCE OF ACUPUNCTURE?
  • 18. ENDOGENOUS OPIOIDS Stimulates release of dynorphin, enkephalin, beta-endorphin. Increases endogenous cannabinoid receptors Up-regulates opioids in inïŹ‚amed tissues
  • 19. ENDOGENOUS OPIOIDS Opioid antagonists such as naloxone, can reverse the analgesic effects of acupuncture.
  • 20. NATIONAL INSTITUTE OF HEALTH CONSENSUS STATEMENT, 1997 “Acupuncture is an effective treatment modality for adult postoperative and chemotherapy nausea and vomiting.” “There is sufïŹcient evidence of acupuncture’s value to expand its use into conventional medicine and encourage further studies of its physiology and clinical value”
  • 21. ACUPUNCTURE IS EVIDENCE BASED MEDICINE Research / DataClinical Expertise PatientValues & Expectations
  • 22. The challenges of the acupuncture control: SHAM acupuncture
  • 24. WHO’S 3- STEP LADDER FOR CANCER PAIN RELIEF
  • 25. PAIN
  • 26. PAIN
  • 30. INTEGRATIVE EVIDENCE BASED MEDICINE Research / DataClinical Expertise PatientValues & Expectations
  • 31. Acupuncture is effective for Pain control Nausea and vomiting Fatigue Hot ïŹ‚ashes It is best used alongside conventional medicine early on in treatment, rather than as last resort
  • 32. Alimi D, Rubino C, Pichard-Leandri E. et al.Analgesic Effect of Auricular Acupuncture for Cancer Pain:A Rondomized, Blinded, Controlled Trial. J Clin Oncol. 2003; 21: 4120-6 Bardia A, Barton DL, Prokop LJ et al. EfïŹcacy of complementary and alternative medicine therapies in relieving cancer pain: a systematic review. J Clin Oncol 2006; 24: 5457-5464 Langevin H,Yandow J. Relationship of Acupuncture Points and Meridians to Connective Tissue Plans. The Anatomical Record 2002: 269: 257-265. Lau C,Wu X, ChungV. et al. Acupuncture and Related Therapies for Symptom Management in Palliative Cancer Care: Systematic Review and Meta-analysis. 2016: 95: 2901 Lee H, Schmidt K, Ernst E.Acupuncture for the relief of cancer-related pain: a systematic review. Eur J Pain 2005; 9: 437-444. Lesi G, Razzini G, Musti M, et al.Acupuncture As an Integrative Approach for the Treatment of Hot Flashes in Women with Breast Cancer:A prospective Multicenter Randomized Control Trial. Journal of Clin Oncology 2016; 2893. Mao JJ, Xie SX, Farrar JT, et.al.A Randomised trial of electro-acupuncture for arthralgia related to amromitase inhibitor use. Euro J Cancer. 2014; 50: 267-76 McCarthy L, Dolovich L, Haq M. et al. Frequency of risk factors that potentially increase harm from medications in older adults receiving primary care. Can J Clin Pharmacol. 2007:14; 283-90 Mehling WE, Jacobs B,Acree M, et. al. Symptom Management with massage and acupuncture in postoperative cancer patietns: a randomized controlled trial. J Pain Symptom Manage. 2007; 33: 258-66
  • 33. Molassiotis A, Bardy J, Finnegan-John J, et. al.Acupuncture for cancer-related fatigue in patients with breast cancer: a pragmatic randomized controlled trial. J Clin Oncol. 2012; 30: 4470-6. Quin MX, Xi CY, Zhou H. Observation on effect of acupoint injection for treatment of morphine induced constipation. J Qiqihar Med Coll. 2010: 31:3921. Rostock M, Jaroslawski K, Guethlin C. Chemotherapy induced, peripheral neuropathy in cancer patients: a four arm randomized trial on the effectiveness of acupuncture. Evid Based Complement Alternat Med. 2013; 349653. Shen J,Wegner N, Glaspy J. et al. Electroacupuncutre for control of myeloablative chemotherapy-induced emesis: a randomized controlled tiral. JAMA 2000; 284: 2755-61 Smith C, Carmady B,Thornton C, et al.The effect of acupuncture on post-cancer fatigue and well-being for women recovering from breast cancer: a pilot randomized controlled tiral.Acupunct Med. 2013;31:9-15. Tang WR, Chen WJ,Yu CT, et al. Effects of acupressure on fatigue of lung cancer patients undergoing chemotherapy: an experimental pilot study. ComplementTher Med. 2014; 22: 581-591 Tao W, JIang H,Tao X. et al. Effects of Acupuncture,Tuina,Tai Chi, Qigong, and Traditional Chinese Medicine Five- Element Music Therapy on Symptom Management and Quality of Life for Cancer Patients:A Meta-analysis. J Pain Symptom Manage. 2016 51; 728-47 Towler P, Molassiotis A, Brearley SG.What is the evidence for use of acupuncture as an intervention for symptom management in cancer supportive and palliative care: an integrative overview of reviews. Support Care Cancer 2013: 21:2913-2923 ZengY, Luo T, Finnegan-John J, et al. Meta-analysis of randomized controlled trials of acupuncture for cancer-related fatigue. Integr CancerTher 2013; 13: 193-200