Advance Design

This document summarizes a randomized controlled trial called ADVANCE that studied the effects of intensive blood pressure lowering and glucose control on vascular outcomes in patients with type 2 diabetes. Over 11,000 patients aged 55 and older from 21 countries with elevated vascular risk were enrolled and randomized to different treatment groups. The primary outcomes were macrovascular and microvascular events. Substudies also examined effects on heart function and eye disease.