Aging kidney-structural-and-functional-changes ayman seddik
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The document discusses how aging impacts the kidneys. As people age, their kidneys undergo structural and functional changes such as loss of mass and function, granularity on the external surface, and thickening of arteries. The prevalence of conditions like diabetes, hypertension, and high cholesterol increase with age and contribute to declining kidney function. Studies show that while chronic kidney disease risk increases with age, elderly patients are less likely than younger patients to progress to end-stage renal disease, though a subset will eventually need renal replacement therapy. Nephrologists face the challenge of identifying older patients with declining kidney function who would benefit from interventions to slow progression.
Aging kidney-structural-and-functional-changes ayman seddik
- 1. Dr Ayman Seddik , Msc , MD Assistant Professor of Nephrology Ain Shams University , Consultant nephrologist Dubai Hospital , Dubai Hospital Dubai Health Authority
- 2. OUTLINE 1. Prevalence of CKD and other comorbidties with aging 2. Our kidneys and aging structural and functional changes
- 3. Hilary Cronin and Rose Anne Kenny Part 2: The Aging Kidneys Morphological and Functional Changes Gross granularity and pitting of the external surface Loss of Mass & Loss of Function But with preserved homeostasis
- 4. Diabetes prevalence in the aging
- 6. High cholesterol and statin use in the aging
- 7. Prevalence of Chronic Kidney Disease (CKD) Stages by Age Group in NHANES 1988-1994 and 1999-2004
- 8. Effects of CKD on mortality and cardiovascular disease in the elderly - mean 75yr 0 1 2 3 4 5 6 7 8 All cause death CV death Non-CV death Heart failure MI Stroke Events/100yrs Normal kidney function CKD 1-2 CKD 3-5 Shilpak at al Ann Int Med 2006;145:237
- 9. Baseline eGFR threshold below which risk for ESRD exceeded risk for death for each age group O’Hare 2007 JASN 18: 2758–2765
- 11. ., Sir William Osler, M.D 1849 -1919
- 14. The Hallmarks of the Aging Kidney Intimal Thickening of Interlobular Artery Hyaline Atherosclerosis Reduplication of Internal Elastica Lamina Glomerulosclerosis, Tubular Atrophy, Vascular Changes Hypertrophic Glomerulus, Compensating for Obsolete Ones
- 15. KI (2008) 74, 710–720 Global glomerulosclerosis Moderate IF/TA Arteriolar reveal hyalinosis
- 19. • Age‐associated decrease in GFR is due to reduction in RPF and in Kf (UF coef)
- 23. Factors that mediate and moderate age-related glomerulosclerosis and tubulointerstitial fibrosis. Brenner and Rector's The Kidney, 9th ed.
- 25. CONCLUSION In conclusion, a large and growing number of elderly people meet criteria for CKD. However, many of these patients are less likely than their younger counterparts with similar levels of renal function to progress to ESRD.
- 26. CONCLUSION HOWEVER a subset of older patients with CKD will EVENTUALLY progress to ESRD and these individuals account for a growing proportion of the ESRD population. Thus, a major challenge for nephrologists is to somehow identify the small proportion but large and growing number of older patients with CKD who are most likely to experience progressive loss of renal function and benefit from aggressive efforts to slow progression and to prepare for ESRD management .