This document analyzes the impact of masonry infill walls with central and partial openings on the structural behavior of reinforced concrete frames in seismic regions. Using various modeling techniques and ETABS software, the study presents results on displacement, stiffness, and storey drift, highlighting significant reductions in lateral movements when infill walls are incorporated. The findings advocate for considering the structural contributions of infill walls in design practices to enhance safety and stability during seismic events.