1. Lawrence F. Andrews observed 120 non-orthodontic patient casts and identified six keys that define normal occlusion: molar relationship, crown angulation, crown inclination, rotations, spaces, and occlusal plane.
2. The six keys provide objective standards to diagnose optimal occlusion and proper treatment planning. They include specifications for the interarch relationship of molars, distal angulation and lingual inclination of crowns, lack of tooth rotations, tight contact points between teeth, and a flat occlusal plane.
3. Achieving all six keys through orthodontic treatment results in optimal occlusion and orofacial harmony according to Andrews' research. The keys establish natural occlusion standards to guide orthodont