Antiplatelet Pharmacology Drugs for disorder of blood.pptx.pptx
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- 3. 3 objective • Definition Drugs of antipletlet Mechanism of action Uses of antipletlet Side effect Contraindication
- 4. 4 Definition The antipletlet drug eliminate or reduce the risk of blood clot. they often called blood thinners, but these medication don't really thin your blood .instead,they help prevent or break up dangerous blood clots that form in your blood vessels or heart
- 5. 5 Conti Decrease platelet function Prevent thrombus formation in arteries
- 7. 7 Other Drugs Clopidogrel Prasugrel
- 8. 8 Mechanism of action Aspirin. As shown in the figure, aspirin inhibits platelet cyclooxygenase, a key enzyme in thromboxane A2 (TXA2) generation. Thromboxane A2 triggers reactions that lead to platelet activation and aggregation, aspirin acts as a potent antipletlet agent by inhibiting generation of this mediator
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- 10. 10 Mechanism of action: Thienopyridines act by inhibiting the ADP-dependent pathway of platelet activation. These drugs have no direct effect on prostaglandin metabolism
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- 12. 12 Uses of antipletlet Prevent blood clots Stop bleeding Antiaggregant Effective in arterial circulation CVD prevention Treatment for arteriosclerosis
- 13. 13 Side Effect Bruising or bleeding under the skin Nose bleed Diarrhea Tummy pain Indigestion Increase bleeding from wound
- 14. 14 Contraindication Antipletlet drugs cause bleeding Hypersensitivity and allergy Aspirin can cause bronchospasm Hypertension should be controlled (BP<150/90mmHg) before commencing treatment.
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