Apc tcell stimulation animation
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The document discusses T cell activation and the role of calcium signaling. Upon antigen presentation by a cell through peptide-MHC complexes and co-receptors, T cells activate several signaling pathways that increase intracellular calcium levels. The rise in calcium activates calcineurin which dephosphorylates NFAT, allowing it to enter the nucleus and induce IL-2 transcription along with other transcription factors like AP-1 and NF-κB.
Apc tcell stimulation animation
- 1. TCR complex Ca2 + Ca2+ Ca2+ T Cell AP-1 Ca2 + Ca2+ Ca2+ κB IκB κBNFAT DAG IP3 PIP2 Ca2+ Ca2+ Ca2+ Ca2+ Ca2 + Ca2+ Calcineurin U b U b U b IKK PKCθ Antigen Presentation CellPeptide-MHC & Co-receptors Ub NFAT PMA NFκB ERK/JNK activation MAP Kinase Ionomycin IL-2 transcription PKCθ