ApolloDx's mDx Platform - Real-Time Results Transmitted Instantly

Real-Time Mobile Diagnostics & Analytics
Confidential - Patents Pending
Real-Time Diagnostics | Data Transmission | Integration | Analytics

Current IVD Testing versus True POCT & Real-Time Analytics
Label specimen
Sort
Obtain/review results
Collect specimen
Hours to days
for results
Problem
Process samples
Perform pre-analytical
procedures
Real-time results
at a lower cost +
Solution
Bidirectional data transmission
provides real-time analytics enabling
medical professionals to make high-
quality decisions and to practice
evidence-based medicine.
Receive results
hours to days later
Send to laboratory
+
True point-of-care,
real-time testing
Servers
Note: The problem depicted above also applicable for veterinarians, biosurveillance, food security, agriculture, water testing and more.

System Description
• World’s First: Mobile diagnostic platform that
detects and wirelessly transmits GPS-tagged results
to the ApolloDx data repository
• Lightweight, handheld and battery-operated
system controlled by smart device that
provides the user interface
• Overcomes the turnaround time problem

Detecting & Connecting
This mobile phone-sized system provides
and transmits laboratory-quality GPS-tagged
results in 10 minutes or less.
MRSA

Ease-of-Use
The intuitive software enables use by
medical professionals, technicians, first
responders and civilian population. This
platform is designed to qualify for CLIA
waiver.

Broad Range of Analytes
This test system uses an electrochemical
detection method that detects a broad range of
analytes as shown below. Test results are
qualitative and/or quantitative, depending on
requirements. LITHIUM
0.53
mmol/L

Multiplexing
Unlike other diagnostic technologies, ApolloDx’s is designed
to simultaneously detect a range of heterogeneous analytes,
for example proteins and oligonucleotides.
Protein Gene

Viable versus Non-Viable Pathogen Detection
ApolloDx’s system: designed to distinguish between viable and non-viable
pathogens.
• Culture takes from 1 to 30 days depending on the species, which is problematic in the
context of life-threatening infections.
• Polymerase chain reaction (PCR) cannot distinguish viable bacterial cells from non-
viable cells.
Viable Pathogen Non-Viable Pathogen
Viable but nonculturable (VBNC) http://en.wikipedia.org/wiki/Viable_but_nonculturable

Fast Assay Development Time
Facility
External
Validation*
Internal Validation
HIV U of Nebraska Publication 2 weeks
MRSA U of Ottawa 2-3 days 2 weeks
L-selectin U of Virginia 1.5 weeks first experiment
Theophylline U of Virginia 1 week
*Using ApolloDx reagents
NOTE: Traditional diagnostic assay validation time: 6-12 months!

Thermal Stability
The electrochemical detection system works well in
harsh environmental conditions.

Long Shelf Life
Chemistry used in the test strips and cartridges is designed to
have a shelf life of 5 to 10 years in thermally challenging
environments.
Test strip Test cartridge

Low Cost, Laboratory Quality Results
Smart device, analyzer and test device are
reusable equipment intended for years of service.
Analyzer cost ~ cost of a smart device.
Test strips and cartridges are single-use
consumables competitive with current market
pricing.
Test strip Test cartridge
Analyzer
Smart Device with
ApolloDx app

Geographical Platform Deployment
Platform enables laboratory quality testing in the field and near the patient.

Transmits Real-Time Results
Results can be aggregated into a heat map for real-time and trending purposes.
Test Location Result Value Date Latitude Longitude
Theophylline Salt Lake City Negative < 1 mcg/mL 7/9/14 12:14 PM 40.75132456 111.88332136
Theophylline Dallas Positive 5 mcg/mL 7/9/14 11:48 AM 32.77580000 96.79670000
Theophylline Dallas Positive 12.5 mcg/mL 7/9/14 11:44 AM 32.77578766 96.79668149

Data Integration
The ApolloDx API provides
HIPAA compliant methods for
integrating with existing systems.
LIS Integration
EHR Integration
Heat Mapping
Health Services
Real-Time Analytics
Real-Time Trends
ApolloDx API
Only wireless system: ApolloDx

Data Analytics
Bidirectional data
transmission provides real-
time analytics enabling
medical professionals to
make high-quality decisions
and to practice evidence-
based medicine.
Healthcare provider
ApolloDx Data Repository
and Backend SystemsSmart device with
ApolloDx’s app

Intellectual Property
Multiple Patents Pending
• Diagnostic consumable design and interface with smartdevice
• Smartphone used for controlling medical devices (with
exceptions)
• Downloadable application controlling a diagnostic test
• Electro- and/or pressure-activation forces used to move fluids
within diagnostic consumable controlled by a MCD*
• Electron-generating signals used on a consumable to
quantitate results of a diagnostic test controlled by a MCD
• Analyte-specific, comprehensive support network used to
geocentrically surround the user.
*MCD: Mobile Computing Device

The ApolloDx System
Test device ServersTest strip
User Components
ApolloDx Data Repository
and Backend Systems
Smart Device
with ApolloDx app
L

How It Works
Scan IDs of provider
and patient
Collect sample,
apply to test strip
Insert test strip
into test device
Qualitative and/or
quantitative results
in ≤10 minutes
LITHIU
M
0.5
3
mmol/L
Transmits data
real-time to the ApolloDx
data repository

Current Prototype Testing Device
ApolloDx Test Device

USB Port
Smart Device
Connection
USB Power
Built in Battery
Sample Port
Inside View of Prototype Test Device

“Within any industry, as technology
becomes more decentralized, it manifests
in the form of more efficient, lower cost
and more personalized products or
services.”
Clayton Christiansen
Professor of Business Administration
Harvard University
Decentralizing Testing

“With point-of-care testing, I
think we’ll be amazed by what
happens in five years. And
we’ll be stupefied at what
we’ll be able to do in 10
years.”
Point of Care Testing
Timothy R. Hamill, MD
Vice Chair, CAP POCT Committee
Director of Clinical Laboratories
Univ. of California / San Francisco
CAP Today - May 2014

ApolloDx’s Mobile Diagnostic Platform: System Features
• Ease-of-use
• Broad range of analytes
• Multiplexing
• Thermal stability
• Long shelf life
• Low cost for laboratory-quality results
• In field and near patient use capability
World’s first mobile diagnostic platform detects and
wirelessly transmits GPS-tagged results:
• Connectivity to L.I.S.
• Globally accessible data repository
• Data integration and analytics
• Fast assay development time
• Strong intellectual property
position

ApolloDx’s Mobile Diagnostic Platform: Impact on Diagnostics
Decentralizing laboratory testing with real-time laboratory-
quality results plus data consolidation, integration and
analytics capability:
• Speeds diagnosis
• Improves outcomes
• Lowers costs
• Increases satisfaction

Contact Information
ApolloDx, LLC
310 East 300 South
Salt Lake City, UT 84111-2605 USA
+1 801 652 6334
www.apollodx.com

ApolloDx's mDx Platform - Real-Time Results Transmitted Instantly

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