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- 1. Novo Nordisk® From knowledge graphs via Lego bricks to scientific conversations Dennis Madsen Roland Hangelbroek Vinay Jethava NN GraphDay May 7, 2024
- 2. Novo Nordisk® From knowledge graphs via Lego bricks to scientific conversations Dennis Madsen Roland Hangelbroek Vinay Jethava NN GraphDay May 7, 2024
- 3. Novo Nordisk® Our knowledge graph principles Why Clear purpose with KG Relevant Pipelines to update Interoperability Entities and ontologies
- 4. Novo Nordisk® Named Entity Recognition Entity Linking Relation Extraction NovoLinker
- 5. Novo Nordisk® Named Entity Recognition
- 6. Novo Nordisk® Entity Linking Ontology Vocabulary
- 8. Novo Nordisk® Currently in NovoLinker - Entities • Genes / Proteins – Linked to HGNC, Interpro and Protein Ontology • Chemicals & Drugs – Linked to Chebi and NCIT • Diseases & Phenotypes – Linked to MONDO and HPO • Cell lines – Linked to cellosaurus • Cell types – Linked to cell type ontology (CL) • Geographical locations – Linked to Geonames • Sequence features – Linked to sequence ontology • Organizations – Linked to Wikidata, Crunchbase, ROR • Organisms - Linked to NCBITaxon • Anatomy – Linked to Uberon Gene ontology: • Biological process • Molecular function • Cell component Others: • Assays, medical procedures, devices, miRNA, sequence variants, persons
- 9. Novo Nordisk® Currently in NovoLinker – Relations • Protein – protein interactions • Chemical – protein interactions • Adverse drug effects • Gene – disease relations • Drug– drug interactions • Causal relations
- 10. Novo Nordisk® Use cases | Patents Long complex documents Rich relationships • Patent Families • CPC/IPCR classification hierarchy • References (Patents/Articles) • Inventors/Owners Additional information (figures, tables, sequences)
- 11. Novo Nordisk® Use cases | Patents 11 • Basic schema • Text-based embeddings • Node embeddings • Entity detection using Novo Linker • Enabling agentic interaction with the patent-graph
- 12. Novo Nordisk® Patents (VNJE) anansi (RLHB) (Literature, news, conference notes, pharma pipelines) N L Computational Biology (NYYL) N L Clinical Data (KEGS) NNRCO Screening Data (VMNZ) N L N L Lego bricks
- 13. Novo Nordisk® Chat with data
- 14. Novo Nordisk® 14
- 15. Novo Nordisk® LLM Functions - API Patents (VNJE) anansi (RLHB) (Literature, news, conference notes, pharma pipelines) N L Computational Biology (NYYL) N L Clinical Data (KEGS) NNRCO Screening Data (VMNZ) N L N L A P I
- 17. Novo Nordisk®