The ATLS 10th Edition Updates document outlines several changes to the Advanced Trauma Life Support course, including updates to the initial assessment, management of coagulopathy, thoracic trauma, abdominal/pelvic trauma, head trauma, spinal trauma, musculoskeletal trauma, pediatric trauma, geriatric trauma, pregnancy considerations, burn management, and transfer to definitive care chapters. Key changes include the recommendation of prehospital tranexamic acid administration, use of massive transfusion protocols, needle decompression of tension pneumothoraces in an altered location, and limiting crystalloid resuscitation in pediatrics.