This document discusses the challenges and opportunities for autonomous systems in space. While the 1998 Deep Space 1 mission demonstrated the feasibility of spacecraft autonomy, its adoption has been slow. Some key successes that demonstrated aspects of autonomy include Earth Observing 1, which autonomously acquired science data, and the Mars Exploration Rovers, which have received incremental autonomy upgrades. However, for full adoption there remain challenges in meeting both functional requirements like long-term reliability without human intervention, as well as perceived requirements regarding risk, complexity, and cost. Adoption may increase by ensuring rigorous software verification and validation processes and facilitating software reuse across missions.