![Association of diabetes with age-related macular degeneration in the EUREYE study † Adjusted for age and sex. ‡ Adjusted for age, sex, smoking, education, BMI, alcohol consumption, cardiovascular disease, aspirin use, systolic blood pressure, alpha-tocopherol ratio, vitamin C and lutein. Topouzis F & al. Br J Ophthalmol. 2009 Aug;93(8):1037-41. OR* (95% CI)† OR* (95% CI)‡ AMD grade 1 1.03 1.04 n = 1552 [0.77 to 1.38] [0.76 to 1.40] p = 0.8 p = 0.8 AMD grade 2 0.75 0.75 n = 430 [0.54 to 1.06] [0.54 to 1.04] p = 0.1 p = 0.1 AMD grade 3 1.09 1.14 n = 108 [0.69 to 1.75] [0.77 to 1.71] p = 0.7 p = 0.5 Geographic atrophy 1.08 1.07 n = 38 [0.31 to 3.70] [0.28 to 4.04] p = 0.9 p = 0.9 Neovascular AMD 1.75 1.81 n = 95 [1.11 to 2.76] [1.10 to 2.98] p = 0.016 p = 0.02](https://image.slidesharecdn.com/biblio-dmla-2010-assodmla-200906252824/85/Biblio-association-DMLA-2010-19-320.jpg)
![Retina. 2009 Nov-Dec;29(10):1424-31. Retina. 2010 May 28. [Epub ahead of print]](https://image.slidesharecdn.com/biblio-dmla-2010-assodmla-200906252824/85/Biblio-association-DMLA-2010-29-320.jpg)
![Résultats ≈ PrONTO Nombre comparable d’injections Moins de visites (20 en 3 ans, 7 par an) Retina. 2009 Nov-Dec;29(10):1424-31. Retina. 2010 May 28. [Epub ahead of print]](https://image.slidesharecdn.com/biblio-dmla-2010-assodmla-200906252824/85/Biblio-association-DMLA-2010-30-320.jpg)
Biblio association DMLA 2010
- 1. 2009-2010 : Les (5) articles qu’il fallait lire Dr JF. Girmens Service d’ophtalmologie / CIC503 CHNO des Quinze-Vingts
- 2. 2009-2010 : Les (5) articles qu’il fallait lire
- 3. GENETIQUE
- 4. rs5888 variant of SCARB1 gene is a possible susceptibility factor for age-related macular degeneration Rechercher de nouveaux facteurs de risque génétiques chez des patients sans variant à risque (CFH et ARMS2) 2 populations Française (1241 DMLA / 297 contrôles) Nord-américaine (1257 DMLA / 1732 contrôles) Zerbib J et al. PLoS One. 2009 Oct 5;4(10):e7341.
- 5. rs5888 variant of SCARB1 gene is a possible susceptibility factor for age-related macular degeneration Zerbib J et al. PLoS One. 2009 Oct 5;4(10):e7341.
- 6. rs5888 variant of SCARB1 gene is a possible susceptibility factor for age-related macular degeneration Zerbib J et al. PLoS One. 2009 Oct 5;4(10):e7341.
- 7. rs5888 variant of SCARB1 gene is a possible susceptibility factor for age-related macular degeneration SCARB1 ? Zerbib J et al. PLoS One. 2009 Oct 5;4(10):e7341.
- 8. rs5888 variant of SCARB1 gene is a possible susceptibility factor for age-related macular degeneration SCARB1 code pour un récepteur de surface Métabolisme du cholestérol Exprimé dans l’EP (interaction avec ApoE) Métabolisme de la lutéine et vitamine E Impliqué dans le métabolisme de 3 molécules avec un rôle dans la physiopathogénie de la DMLA Zerbib J et al. PLoS One. 2009 Oct 5;4(10):e7341.
- 9. Genetic variants near TIMP3 and high-density lipoprotein–associated loci influence susceptibility to age-related macular degeneration Chen W & al. Proc Natl Acad Sci U S A. 2010 Apr 20;107(16):7401-6. Epub 2010 Apr 12.
- 10. Genetic variants near TIMP3 and high-density lipoprotein–associated loci influence susceptibility to age-related macular degeneration TIMP3 : metalloprotéinase Dégradation de la matrice extracellulaire Mutation dans la maculopathie de Sorsby LIPC : lipase hépatique CETP : Pn. de transfert du cholestérol estérifié Associés avec hypercholestérolémie (HDL) Chen W & al. Proc Natl Acad Sci U S A. 2010 Apr 20;107(16):7401-6. Epub 2010 Apr 12.
- 11. Applications ?
- 12. Genotypic influences on severity of exudative age-related macular degeneration Leveziel N & al. Invest Ophthalmol Vis Sci. 2010 May;51(5):2620-5. Epub 2009 Dec 30.
- 15. Folic Acid, Pyridoxine, and Cyanocobalamin Combination Treatment and Age-Related Macular Degeneration in Women Christen WG & al. Arch Intern Med. 2009;169(4):335-341.
- 16. Vitamin E and Age-Related Macular Degeneration in a Randomized Trial of Women Christen WG & al. Ophthalmology. 2010 Jun;117(6):1163-8. Epub 2010 Feb 13.
- 17. DMLA ET DIABETE
- 18. Association of diabetes with age-related macular degeneration in the EUREYE study Topouzis F & al. Br J Ophthalmol. 2009 Aug;93(8):1037-41. AMD No diabetes n (%) Diabetes n (%) Total No AMD 1954 (87.0) 292 (13.0) 2246 AMD grade 1 1491 (86.6) 231 (13.4) 1722 AMD grade 2 430 (89.6) 50 (10.4) 480 AMD grade 3 100 (86.2) 16 (13.8) 116 Late AMD 131 (82.9) 27 (17.1) 158 Total 4106 (87.0) 616 (13.1) 4722
- 19. Association of diabetes with age-related macular degeneration in the EUREYE study † Adjusted for age and sex. ‡ Adjusted for age, sex, smoking, education, BMI, alcohol consumption, cardiovascular disease, aspirin use, systolic blood pressure, alpha-tocopherol ratio, vitamin C and lutein. Topouzis F & al. Br J Ophthalmol. 2009 Aug;93(8):1037-41. OR* (95% CI)† OR* (95% CI)‡ AMD grade 1 1.03 1.04 n = 1552 [0.77 to 1.38] [0.76 to 1.40] p = 0.8 p = 0.8 AMD grade 2 0.75 0.75 n = 430 [0.54 to 1.06] [0.54 to 1.04] p = 0.1 p = 0.1 AMD grade 3 1.09 1.14 n = 108 [0.69 to 1.75] [0.77 to 1.71] p = 0.7 p = 0.5 Geographic atrophy 1.08 1.07 n = 38 [0.31 to 3.70] [0.28 to 4.04] p = 0.9 p = 0.9 Neovascular AMD 1.75 1.81 n = 95 [1.11 to 2.76] [1.10 to 2.98] p = 0.016 p = 0.02
- 21. Risk of advanced age-related macular degeneration after cataract surgery in the Age-Related Eye Disease Study: AREDS report 25. Ophthalmology. 2009 Feb;116(2):297-303. Epub 2008 Dec 16. 2009
- 23. Blue-blocking IOLs Decrease Photoreception Without Providing Significant Photoprotection Diminution de 43-57% de lumière bleue / violette affecterait : Contraste photopique Sensibilité des cones S Contraste mésopique Sensibilité scotopique Rythme circadien Mainster MA & al. Surv Ophthalmol. 2010 May-Jun;55(3):272-83
- 24. Blue-Blocking IOLs: A Complete Review of the Literature Pas d’effet significatif (10/11 publications) sur Acuité visuelle Sensibilité aux contrastes Vision des couleurs Sensibilités photopique, mésopique et scotopique (Quelle significativité clinique ?) Henderson BA & al. Surv Ophthalmol. 2010 May-Jun;55(3):290-96
- 25. Blue-Blocking IOLs: A Complete Review of the Literature Pas d’effet significatif (10/11 publications) sur Acuité visuelle Sensibilité aux contrastes Vision des couleurs Sensibilités photopique, mésopique et scotopique (Quelle significativité clinique ?) … mais aucune preuve non plus de leur intérêt ! Henderson BA & al. Surv Ophthalmol. 2010 May-Jun;55(3):290-96
- 27. Ranibizumab for exudative age-related macular degeneration: 24-month outcomes from a single-centre institutional setting Querques G & al. Br J Ophthalmol. 2010 Mar;94(3):292-6. Epub 2009 Dec 1.
- 29. Retina. 2009 Nov-Dec;29(10):1424-31. Retina. 2010 May 28. [Epub ahead of print]
- 30. Résultats ≈ PrONTO Nombre comparable d’injections Moins de visites (20 en 3 ans, 7 par an) Retina. 2009 Nov-Dec;29(10):1424-31. Retina. 2010 May 28. [Epub ahead of print]
- 32. En attendant CATT, GEFAL, IVAN, VIBERA, MANTA, LUCAS …
- 33. En attendant CATT, GEFAL, IVAN, VIBERA, MANTA, LUCAS …
- 34. En attendant CATT, GEFAL, IVAN, VIBERA, MANTA, LUCAS …
- 35. En attendant CATT, GEFAL, IVAN, VIBERA, MANTA, LUCAS …
- 36. POUR FINIR…
Editor's Notes
- #4: Vers de nouvelles pistes et de nouveaux traitements ?
- #6: CT hetero. A risque augmenté de DMLA
- #7: Dans les populations sans autre facteurs de risque, heterozygte CT augmente le risque de DMLA, surtout exsudativce
- #18: DMLA et rétinopathie diabétique sont les deux patjologies les plus fréquentes dans les pays développés Peu de données sur un éventuel lien entre les deux Peu d’association entre DMLA et RD Or un lien semble exister, uniquement pour les formes exsudatives
- #19: Eureye 2182 oatients comparés à 2117 contrôles 49 atrophiques 101 exsudatives
- #20: Association significative entre diabéte et néovaisseaux choroidiens Mais pas avec formes précoces et atrophie gféographique NV et atrophie resulteraient donc de mécanismes différents
- #22: The results from the Cox proportional hazards models used to examine AREDS data show little evidence of a detrimental effect of cataract surgery on progression to advanced AMD. Use of the Cox regression model allows us to take advantage of a unique feature of AREDS, the ability to examine the effect of important covariates, including time-dependent covariates, on progression to late AMD. Results from the Cox models are not statistically significant and there are no consistent trends among models, with point estimates for risk of neovascular AMD in the harmful direction for the matched pair analyses and in the protective direction for the logistic regression analyses. For GA results, all models had point estimates in the direction of protection, suggesting that it is unlikely that there is any risk of cataract extraction on the development of GA. The absence of any consistent pattern in the direction of harm across models reinforces the conclusion that AREDS data provide little evidence that cataract surgery increases the risk of progression to late AMD.