Bioinfo intro
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Bioinformatics uses databases and computers to answer biological questions through activities like annotating biological data and manipulating information. It involves fields like molecular biology, genomics, systems biology, and more. The history of bioinformatics began in the pre-1970s with early sequence alignment algorithms and studies on protein structure and evolution. It expanded in the 1970s and 1980s with more advanced algorithms and resources for tasks like sequence analysis, molecular databases, and protein structure prediction. The course will cover topics like biological databases, nucleotide sequence analysis, statistical methods, protein structure modeling, and applications like genomics, proteomics, and drug design.
Bioinfo intro
- 1. What is Bioinformatics? Use of databases and computers to ask and answer biological questions
- 2. What is Bioinformatics? Major activities are, 1.Annotation of biological information 2.Transformation and Manipulation of data
- 3. Areas - Molecular biology - Genomics - Systems biology - Protein design and engineering - Pharmaceutical development - Medicine - Ecology/ Population genetics
- 4. History The pre-70’s -The first sequence alignment algorithms -Preferential substitution of amino acids in protein sequences -Studies on protein primary structure -Use of mol bio data in evolutionary studies -Theory of evolution by gene duplication -Central dogma
- 5. History The 70’s -Studies of substitution mutation rates -Calculation of solvent accessibility on protein structures -Parsimonial determination of tree topology -RNA structure prediction -Sequence alignment methods
- 6. History The 80’s More algorithms and resources 1.Sequence analysis 2.Molecular databases 3.Protein structure prediction 4.Molecular evolution
- 7. Twenty publications that influenced present view
- 8. Applications Genomics Proteomics Cheminformatics and Drug design Molecular phylogenetics Drug modification
- 9. What we are going to study?
- 10. Unit I Introduction to bioinformatics and Biological databases
- 11. Unit II Nucleotide sequence analysis and RNA structures
- 12. Unit III Statistical methods in Bioinformatics
- 13. Unit IV Structure and modeling of Proteins
- 14. Unit V Bioinformatics applications and drug modeling