Biomarker base™ Introduction
- 1. Unified Data for Actionable Biomarkers
- 2. What Is BiomarkerBase? • A manually curated database that aggregates information from publicly available sources that describe the clinical use of biomarkers. • Provides access to biomarkers that can’t be found through searches in public sources. • Links biomarker information together by target, disease, drug, therapeutic area, and company. 2 http://www.biomarkerbase.com
- 3. - IVD Tests cleared or approved by FDA since the end of 2002 that utilize one or more biomarkers. - Drugs, all FDA-approved, that include a biomarker in the label. - Clinical Trials, phase 3 and 4, initiated since the end of 2011, which include “marker” in the record. Phase 2 trials by Nov ‘13. - Publications describing clinical studies that include biomarkers from the sources above. Current Datasets Biomarker Definition: A nucleic acid, peptide or hormone that is potentially useful for diagnosis, prognosis, or companion diagnosis. 3
- 4. Public sources of biomarker information lack connectivity and have severe querying limitations. 4
- 5. Query limitation #1: Some of the most critical information can’t even be searched. X 5
- 6. Query limitation #1: Some of the most critical information can’t even be searched. 6 X
- 7. Query limitation #2: Nomenclature isn’t standardized. Search Term Studies Returned ca 125 153 ca-125 140 mucin-16 138 mucin 16 138 MUC16 0 7
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- 10. Who Uses BiomarkerBase? Diagnostic Companies Product development; business development; marketing Drug Companies Clinical trial planning; partnering; test selection Life Science Companies Product development; business development; marketing Research Institutions Licensing 10
- 11. Subscription Pricing Single User • $1,000 / year • Access for one individual Multi User • $2,500 / year • Unlimited users at a single site within one company or institution • Multi-site licenses are also available at discounted pricing. 11
- 12. Amplion Research Inc. 1011 SW Emkay Drive, Suite 200 Bend, Oregon 97702 USA support@amplion.com +1.503.389.1157 Contact Information 12