Bookshelf.js is a JavaScript ORM for Node.js that provides a framework for managing relations and querying a relational database. It supports MySQL, Postgres, and SQLite databases and follows Backbone conventions for models, collections, and entity relationships like hasOne, hasMany, belongsTo, and belongsToMany. Bookshelf.js also provides features like polymorphism, eager/lazy loading, events, promises/callbacks, utilities like Knex for querying and migrations, and plugins. To use it, an application first connects to a database via Knex and defines models as Bookshelf classes that extend the knex connection before performing queries and other operations.