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Dr. Brian J. Spiering
Building Better Models in
Cognitive Neuroscience:
THEORY
Building better models in cognitive neuroscience. Part 1: Theory
Building better models in cognitive neuroscience. Part 1: Theory
Building better models in cognitive neuroscience. Part 1: Theory
Better models
help solve
better problems
How to Build Better
A) Why?
B) Ideals
C) Modeling
Cognitive Neuroscience
Models
Building better models in cognitive neuroscience. Part 1: Theory
Increased
Constraints
Find Unexpected
Relationships
Make Novel
Predictions
Better Model
Testing
IDEALS
Neuroscience
1) Be consistent only known connections
2) Excitatory or Inhibitory Connections: Pick One
3) Predicted behavior consistent with known behavior
4) Predicted learning consistent with known learning
Simplicity
Set-in-Stone
Input
Black Box
Output
Goodness-of-Fit
Biological Simplicity
vs.
Scalability
Units
Connections
Learning
Behavior
Units
MODELING
UNITS
Leaky Integrate-and-fire Model
Leaky Integrate-and-fire Model
Leaky Integrate-and-fire Model
Activation
Set spiking threshold,Vpeak,
onVB(t)
Building better models in cognitive neuroscience. Part 1: Theory
Leaky Integrate-and-fire Model
with quadratic polynomial
Building better models in cognitive neuroscience. Part 1: Theory
Izhikevich model
See Figure 3 in Paper
Units
Connections
Axon & Synaptic Delays
Break
L
E
A
R
N
I
N
G
Units
Connections
Learning
Long-Term Potentiation
(LTP)
Long lasting increase in
the efficacy of a synapse
Long-Term Depression
(LTD)
Long lasting decrease in
the efficacy of a synapse
Dopamine
Important function
but depends on location
Building better models in cognitive neuroscience. Part 1: Theory
Building better models in cognitive neuroscience. Part 1: Theory
Discrete-Time
vs.
Continuous-Time
Discrete Time & Slow DA Reuptake
Discrete Time & Slow DA Reuptake
Discrete Time & Fast DA Reuptake
Modeling Dopamine Release
Input
Black Box
Output
Predicted
Reward
-
Reward
Prediction
Error
(RPE)
Obtained
Reward
=
Obtained Reward (Simple)
+1 if correct
-1 if error
Predicted Reward (Simple)
Dopamine &
Reward Prediction Error
Continuous-time models of learning
Learning Rules:
Local
vs.
Global
Building better models in cognitive neuroscience. Part 1: Theory
Building better models in cognitive neuroscience. Part 1: Theory
+
BEHAVIOR
Units
Connections
Learning
Behavior
1) Which brain regions
controls behavior?
Input
Black Box
Output
2) What is the neural activity
function that drives the decision?
1)Integrated neural activity
2)Spiking behavior
3)Integrated output alpha function
Integrated Output Alpha Function
3) How is response
competition resolved?
Two Choice Tasks
1)Diffusion Model
2)Accumulator/Race Model with
Lateral Inhibition
>Two Choice Tasks
• Set criterion at each decision unit
• 1st unit that crosses threshold “wins”
• Add lateral inhibition
OVERCONNECTING
Have a Happy
Thanksgiving!

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Building better models in cognitive neuroscience. Part 1: Theory