This document summarizes a research conference on Housing First programs for the homeless with mental illness. It discusses the At Home/Chez Soi project, the largest Housing First study in the world conducted across 5 Canadian cities. Interim results found Housing First reduced health system costs and increased housing stability. Efforts were made to promote sustainability after funding ended through negotiations. Current priorities are the project transition and disseminating findings to scale up Housing First nationally through toolkits and partnerships. Housing First is now a major policy shift in Canada with renewed homelessness funding and the Mental Health Commission's advisory role on implementation.