A Study on Pattern of Using Prophylactic Antibiotics in Caesarean Section

IOSR Journal Of Pharmacy
(e)-ISSN: 2250-3013, (p)-ISSN: 2319-4219
www.iosrphr.org Volume 5, Issue 1 (January 2015), PP. -12-18
12
A Study on Pattern of Using Prophylactic Antibiotics in
Caesarean Section
Shamna.M.S1*
, V.K.Kalaichelvan2
, Y.M.Fazil Marickar3
, R.Manavalan4
,
K.Kannan5
, Deepu.S6
1
(Department of Pharmacy Practice, Mar Dioscorus college of Pharmacy, Trivandrum, India,
2
(Department of Pharmacy, Annamalai University, Annamalai Nagar, TamilNadu, India)
3
(Department of Surgery, Mount Zion Medical College, Adoor, Pathanamthitta, India)
4
5
6
(Department of Pharmaceutics, Mar Dioscorus college of Pharmacy, Trivandrum, India)
Abstract: An estimated 40-60% of SSI are preventable with appropriate use of prophylactic antibiotics. The
major infectious complications of caesarean delivery are fever, wound infection, endometritis and urinary tract
infection. Prevention of surgical site infection is the major goal of antibiotic prophylaxis. Postoperative
surgical site infection remains a major source of illness and a less frequent cause of death in the surgical
patient. The administration of prophylactic antibiotics with in specific interval has been shown to reduce the
burden of surgical site infection, but adherence to proper timing guidelines remains problematic. Judicious use
of antibiotics in the hospital through effective antibiotic policy and guideline development is then essential.
Keywords: Cesarean section, Post Caesarean infectious complication, Prophylactic antibiotics, Surgical
antibiotic prophylaxis, Surgical antimicrobial prophylaxis.
I. INTRODUCTION
Antibiotics administered prior to the contamination of previously sterile tissues or fluids are deemed
‘prophylactic antibiotics’. Prevention of surgical site infection is the major goal of antibiotic prophylaxis.1
An
estimated 40-60% of SSI are preventable with appropriate use of prophylactic antibiotics1
.
The development of clinical infection is dependent on a complex balance between host defence mechanisms and
bacterial virulence factors. Cesarean delivery alters this balance so as to predispose the patient to infection.
During labor and abdominal delivery, the endometrium and peritoneal cavity invariably are contaminated with
large numbers of highly pathogenic aerobic and anaerobic bacteria2
.
Type of antimicrobials: Since the time chemotherapeutic drugs and antibiotics are available, they have been
administered following clean surgery to reduce infectious morbidity3
. The surgeon is faced with a bewildering
array of antimicrobials. But a few antimicrobials are frequently used by the surgeon.
Penicillin’s: This class represents one of the most important groups of anti-infective agents. They are
bactericidal and act by interfering with the synthesis of bacterial peptidoglycan cell wall. The broad use of
penicillin’s has been eclipsed by other drugs because of the emergence of resistance in microorganisms that
produce penicillinase as well as emergence of methicillin resistant staphylococcus. Penicillin’s are effective

A Study On Pattern Of Using…
13
against gram positive organisms and neisseria gonorrhoeae. The aminopencillin (ampicillin, amoxicillin) also
has got limited gram negative activity. Pencillinase resistant penicillin’s are useful against resistant
staphylococci. Penicillin’s have allergic reactions ranging from rashes to anaphylaxis4
.
Cephalosporin’s: Cephalosporium acremonium, the first source of the cephalosporin’s was isolated in 1948 by
Brotzu. Cephalosporin’s are bactericidal and by inhibition of cell wall synthesis.
They are classified as follows:
(1) First generation : eg. Cefadroxyl, Cephalexin, Cephalothin, Cefazolin
(2) Second generation : eg. Cefaclor, Cefamandole, Cefoxitin, Cefuroxime, Cefotetan
(3) Third generation : eg. Cefotaxime, Ceftriaxone, Cefixime, Cefoperazone
(4) Fourth generation : eg. Cefepime, Cefpirone
First generations have good activity against a wide spectrum of gram positive bacteria including
pencillinase producing but not methicillin resistant staphylococci. Enterococci are however resistant. Activity
against gram negative is modest.
They are available in both oral and parenteral forms. In this group, Cefazolin has widely used as a
prophylactic drug in high risk elective operations. The major advantages of second generation cephalosporin’s
are improved activity against important gram negative organisms. Unique feature is its activity against
Haemophilus influenzae including strains producing beta lactamases. Not active against Pseudomonas, proteus
and enterococci4
.
Third generation cephalosporin’s are active against gram-positive and gram -negative microorganisms.
It is stable to beta–lactamase produced by many organisms, and has good activity against beta-lactamase
producing organisms. Some of the drugs in this class have been suggested as primary single therapy for
infections such as nosocomial pneumonia and peritonitis. The major advantage of these drugs over combination
of aminoglycosides with earlier generation cephalosporin for infections is lack of toxicity and elimination of
need to monitor drug levels. Toxic side effects are unusual. Fourth generations have a very broad spectrum of
activity4
.
Aminoglycosides: Aminoglycosides are bactericidal antibiotics interfering with bacterial protein synthesis.
They have post antibiotic effect ie antibacterial activities persisting after concentrations have dropped below
minimum inhibitory concentrations. Toxicity is the major drawback, involving renal insufficiency and
ototoxicity .Gentamicin, Tobramycin and Amikacin belong to this group of antimicrobial drugs. These drugs are
given parenterally because of poor intestinal absorption. Adjustments of amino glycoside doses are frequently
necessary because of inadequate levels or poor clinical response4
.
Metronidazole: Metronidazole is an antiprotozoal and antibacterial drug used in the treatment of bacterial
infections caused by anaerobic microorganisms. Metronidazole is also used for prophylaxis against post-
operative infections4
.

14
II. OBJECTIVES OF THE STUDY
 To study the pattern of using antibiotic prophylaxis in Caesarean section.
 To study the effect of prophylactic antibiotics on maternal and neonatal infectious complications.
 Monitor any adverse drug reactions occurring during hospital stay.
 To evaluate the cost of therapy.
Considering the aims, the study was structured in the following manner:
Design of a structured data collection form.
Getting Ethical Committee clearance to conduct this study.
Screening of patients admitted to the Hospital, using the selection criteria.
Recording the clinical data of prophylactic antibiotic therapy of the patients selected
after getting a written consent from the patient.
Evaluating the effect of antibiotic prophylaxis on maternal infectious complications, monitoring of adverse
drug reaction and cost evaluation.
Recording the data’s associated prophylactic therapy.
Statistical analysis of data.
Interpretation of results.
RESEARCH DESIGN AND METHODOLOGY
A. Study setting:
The study was conducted in the inpatient department of the obstetrics and gynecology of the Hospital.
B. Period of study:
6 Months (From June 2014 to November 2014)
C. Design of study:
Prospective observational study.
D. Study population:
100 patients admitted and delivered by Caesarean section & Meeting all the inclusion criteria during
the study period.
E. Selection criteria:
Inclusion criteria:
 Patients who are in the age group of 18-40 years.
 Patients who are admitted for Caesarean deliveries.
Exclusion criteria:
 Patients who are already on antibiotic therapy for any infections.
 Patients whose data is insufficient.

15
F. Research study approval and consent:
The study was approved by the Human Ethical Committee. All patients participating in the study
provided consent. Confidentiality of all patient information was strictly maintained.
G. Statistical analysis: The data were entered in Microsoft Excel format and the statistical analysis were done
using SPSS for Windows version 21.0.
Data Collection:
Those cases which met study criteria were identified from the wards. Information on patients admitted
for Caesarean delivery was collected and recorded in a standard proforma by reviewing their medical records
after getting a written consent from the patient. Additional information was collected by interviewing the patient
or the bystanders. The patient’s condition was monitored daily till the day of discharge from the hospital.
Confidentiality of the patient information was maintained strictly. Human Ethical Committee clearance was
obtained for the study
IV. RESULTS AND DISCUSSION:
Total of 100 patients between age group 18 to 40 were considered for the study.
Data on nature of surgery:
Categorization of patients based on nature of surgery:(Table – 1)
No. of patients %
Elective 73 73.0%
Emergency 27 27.0%
Majority of the patients were undergoing elective Caesarean section (73%).
Data on surgery period:
Categorization of patients based on period of surgery:
(Table – 2)
No of patients %
45 minutes 80 20.0%
45 minutes to 1 hour 20 62.0%
From analysis it was found that 80% cesarean section takes 45 minutes and 20% takes 45 minutes to
one hour in our study.
Data on commonly used antibiotics for prophylaxis:
Categorization of patients based on usage of antibiotics: (Table – 3)
No. of
patients
%
Amoxicillin 99 99.0%
Azithromycin 1 1.0%
Cefotaxime 100 100.0%

16
In our study Cefotaxime was the commonly used antibiotic (100%) and the second most drug used was
amoxicillin (99%) .Azithromycin was used for only one patient.
Data on timing of prophylaxis:
Categorization of patients based on timing of prophylaxis: (Table – 4)
From total of 100 patient’s majority of patients receives ½ hour before surgery (80%).
Data on no of days of post op antibiotics:
From analysis all the patients received post operative antibiotic for 10 days.5 days IV and remaining 5
days orally.
Data on early switch from iv to oral antibiotics:
For all the patients IV to Oral switch therapy was in 5th
day of therapy.
Data on Adverse drug reactions:
In our study there were no adverse reactions reported in both groups.
Data on Drug allergy:
There were no cases of drug allergy reported.
Trade Name Vs Generic Name:
All the prescriptions were in generic name.
Maternal Complications:
Categorization of patients based on maternal infections after cesarean delivery:
(Table – 5)
No. of
patients
%
Fever 0 0
Wound infection 0 0
Endometritis 0 0
UTI 0 0
In the analysis there were no infectious complications reported after Caesarean section.
No. of patients %
1/2 hour before 80 80
1/2 to 1 hour before 20 20

17
Cost evaluation:
There were no costs incurred from patients because they all were registered in Janani Sisu Suraksha
Karyakram (JSSK) and Janani Suraksha Yojana (JSY) Scheme sponsored by Central government for mother
and child care and also for minimizing home delivery. So all patients underwent Cesarean delivery was free of
cost.
V SUMMARY:
The use of antibiotic prophylaxis before surgery has evolved greatly in the last 20 years.
Improvements in the timing of initial administration, the appropriate choice of antibiotic agents, shorter duration
have defined more clearly the value of this technique in reducing postoperative wound infections. Women
taking antibiotics just before, during or just after their cesarean section operation are much less likely to have
infection of their womb & wound. The study population consisted of 100 patients delivered by cesarean section
during the period June-November 2014.Their condition was monitored till the day of discharge & outcomes
were recorded.
The salient findings of this study were:
 Majority of the patients were undergoing elective Caesarean section (73%).
 Mean surgery period is ½-1hour.
 All the patients received cefotaxime for surgical prophylaxis.
 Majority of patients take antibiotics 1/2hour before surgery.
 All the patients take postoperative antibiotics for 10 days.
 Patients switched over to oral therapy in the 5th
day.
 There were no adverse reactions reported in our study.
 There were no cases of drug allergy reported.
 Prescriptions were in generic form.
 The antibiotic prophylaxis effectively reduced the rate of postpartum infections like fever, endometritis,
wound infections, urinary tract infections etc. There were no infectious complications found in our
study.
 There were no costs incurred from patients for Caesarean delivery.
VI CONCLUSION:
The antimicrobial should be safe for the patient and economical for the hospital. The concept of clinical
pharmacy is being advocated in health care practice to promote rational drug use. Clinical pharmacists will have
to consider the clinician’s choice of drugs to provide the most cost effective therapy. A concentrated effort
should be made in areas of clinical surgery where the value of antibiotic prophylaxis has not been proven.
REFERENCES:
1. Dipiro J T. Pharmacotherapy-A path physiologic approach.5th
ed, 1999, 2111-2120.
2. Thigpen BD, Hood WA, Chauhan S, Bufkin L, Bofill J, Magann E, Morrison JC.Timing of
prophylactic antibiotic administration in the uninfected laboring gravida: a randomized clinical trial.
Am J Obstet Gynecol 2005 Jun,192(6),1864-8 .
3. Survey and evaluation of antibiotic prophylaxis usage in surgery wards of tertiary level institution

18
before and after the implementation of clinical guidelines. Indian journal of surgery 2006, 68 (3):150-
156.
4. Goodman and Gilman, Hardman GJ, Limbird EL. The pharmacological basis of therapeutics. 9th
edition.1996, 1091-99.
5. Antimicrobial prophylaxis for surgery. An advisory statement from the national surgical infection
prevention project. Clinical infectious diseases 2004, 38, 1706-15.

A Study on Pattern of Using Prophylactic Antibiotics in Caesarean Section

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A Study on Pattern of Using Prophylactic Antibiotics in Caesarean Section