This case presentation describes a 33-year-old male patient with a history of major depressive disorder and anxiety disorders who was admitted to the psychiatric unit due to worsening depression and suicidal ideation. During his hospitalization, he received ECT treatment and medication changes which resulted in significant improvement in his mood, energy, motivation, and resolution of suicidal thoughts. His diagnosis was refined to atypical depression with panic disorder based on the atypical features of his depression. Computational psychiatry analysis of his symptoms before and during treatment found moderate generalized anxiety due to instability in brain systems and marked depression due to decreased brain plasticity, both of which improved with the administered treatment plan.