The document discusses various clinical factors that can affect the outcome of endodontic treatment. It covers historical concepts of endodontic success and failure. Key factors that influence treatment outcomes include thorough debridement and disinfection of the root canal, obtaining an adequate apical seal, clinical signs and symptoms, radiographic findings, root canal anatomy, systemic health status, and the clinician's skill level. The document also provides guidance on assessing case difficulty and determining whether a case should be treated or referred.