Cell Division And Connection By D Gnanasingh Arputhadas
 Cell ------------------------------------------------------- 3
 DNA vs RNA ------------------------------------------ 4
 Chromosomes ----------------------------------------- 5
 Cell Cycle ----------------------------------------------- 6
 Mitosis --------------------------------------------------- 9
 Meiosis -------------------------------------------------- 18
 Mitosis vs Meiosis ----------------------------------- 20
 Crossing Over ----------------------------------------- 21
 Cell Junction ------------------------------------------- 22
 Gap Junction ------------------------------------------ 23
 Tight Junction ----------------------------------------- 24
 Desmosomes ------------------------------------------- 25
 Hemidesmosomes ------------------------------------ 26
 References ----------------------------------------------- 27
 Cell is the basic structural, functional and
biological unit of all known living organisms
 Often called as building blocks of life.
DNA
 Double stranded
 A=T, G= C
 Carries genetic
information in most
of the organisms
 Single stranded
 A=U, G=C
 Carries genetic
information in some
viruses
 Types:
 messenger RNA
 transfer RNA
 ribosomal RNA
RNA
• Condensed DNA.
• DNA that is
preparing to undergo
cellular division
• Can now be seen with
a microscope.
 G0 Phase
 Interphase
(90% of cell cycle)
 Gap 1 (G1)
 Synthetic phase (S)
 Gap 2 (G2)
 Mitosis
(10% of cell cycle)
 Resting phase
 Cell leaves the cell cycle and stops dividing
 G0 phase is viewed as either an extended
G1 phase, where the cell is neither dividing nor
preparing to divide, or a distinct quiescent
stage that occurs outside of the cell cycle.
• G-1: Maturation.
• S-Phase: DNA replicates - makes a
duplicate copy of itself.
• G-2: Organelles replicate and final
preparations for division.
 Division of the nucleus
 Also called
karyokinesis
 Only occurs in
eukaryotes
 Has four stages
 Doesn’t occur in some
cells such as brain cells
10
Prophase
Metaphase
Anaphase
Telophase
• The chromatin
condense to form
visible chromosomes
• The nuclear envelope
begins to dissolve
• The centrioles divide
and begin to migrate to
opposite sides of the
cell
• Centrioles have
moved to opposite
sides of the cell
• The spindle has
formed
• Chromosomes are
lined up in the middle
of the cell across the
equator
• The centromeres split
and the spindles pull
the sister chromatids
apart toward opposite
sides of the cell
• The chromosomes
move to opposite
sides of the cell.
• The nuclear envelope
begins to reform
around each set of
chromosomes at
opposite sides of the
cell.
• Division of the
cytoplasm
• Begins to occur
during telophase
• Different in plants
and animal cells
Cell Division And Connection By D Gnanasingh Arputhadas
Cell Division And Connection By D Gnanasingh Arputhadas
 Only occurs in sexually reproducing organisms
 The goal of Meiosis is to produce gametes
 2 cell divisions result in 4 daughter cells
 The chromosome number is halved
 Meiosis increases variability as no 2 gametes
are the same
 Involves two successive divisions
 Meiosis I
 Meiosis 2
Cell Division And Connection By D Gnanasingh Arputhadas
Cell Division And Connection By D Gnanasingh Arputhadas
 Crossing over consists of a mutual exchange of
equal quantity (segments) of chromosomal
material between two non-sister chromatids.
Cell Division And Connection By D Gnanasingh Arputhadas
 Adjacent plasma
membrane are closely
opposed. intercellular
space narrows upto
2-3 nm.
 Gap junctions are
made up of large
protein units called
CONNEXONS
 "Zonula“ means band
 "occludens" = that close
off the space between
the cells.
 are the most apical of
the junctions
 Seal cells of an epithelial
sheet to create a
permeability barrier
(MCQ)
 This junctional type
resembles a single
"spot-weld" and does
not form a belt around
the cell
 Cadherins:
transmembrane
proteins.
 Bind intermediate
filaments rather than
actin filaments
 Adhere epithelial cells
to the basal membrane
 Integrins are the
transmembrane
proteins.
 Anchor proteins link
integrins to
intermediate filaments
1. Alberts, Bruce, “Molecular Biology Of Cell”, 4th
Edition, Garland Science, 2008.
2. Lodish, Harvey etal., “Molecular Cell Biology”,
6th Edition, W.H.Freeman, 2008.
3. Dr. Liz Williams, “The Journal Of Cell
Biology”, Volume 194, No. 3, August 8,2011.
4. Kara Rogers, “The Cell”, 1st Edition, Britannica,
2011.
Submitted to
Dr.P.Dhasarathan Ph.D,
Senior Assistant Professor,
Department Of BioTechnology,
PITAM.

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Cell Division And Connection By D Gnanasingh Arputhadas

  • 2.  Cell ------------------------------------------------------- 3  DNA vs RNA ------------------------------------------ 4  Chromosomes ----------------------------------------- 5  Cell Cycle ----------------------------------------------- 6  Mitosis --------------------------------------------------- 9  Meiosis -------------------------------------------------- 18  Mitosis vs Meiosis ----------------------------------- 20  Crossing Over ----------------------------------------- 21  Cell Junction ------------------------------------------- 22  Gap Junction ------------------------------------------ 23  Tight Junction ----------------------------------------- 24  Desmosomes ------------------------------------------- 25  Hemidesmosomes ------------------------------------ 26  References ----------------------------------------------- 27
  • 3.  Cell is the basic structural, functional and biological unit of all known living organisms  Often called as building blocks of life.
  • 4. DNA  Double stranded  A=T, G= C  Carries genetic information in most of the organisms  Single stranded  A=U, G=C  Carries genetic information in some viruses  Types:  messenger RNA  transfer RNA  ribosomal RNA RNA
  • 5. • Condensed DNA. • DNA that is preparing to undergo cellular division • Can now be seen with a microscope.
  • 6.  G0 Phase  Interphase (90% of cell cycle)  Gap 1 (G1)  Synthetic phase (S)  Gap 2 (G2)  Mitosis (10% of cell cycle)
  • 7.  Resting phase  Cell leaves the cell cycle and stops dividing  G0 phase is viewed as either an extended G1 phase, where the cell is neither dividing nor preparing to divide, or a distinct quiescent stage that occurs outside of the cell cycle.
  • 8. • G-1: Maturation. • S-Phase: DNA replicates - makes a duplicate copy of itself. • G-2: Organelles replicate and final preparations for division.
  • 9.  Division of the nucleus  Also called karyokinesis  Only occurs in eukaryotes  Has four stages  Doesn’t occur in some cells such as brain cells
  • 11. • The chromatin condense to form visible chromosomes • The nuclear envelope begins to dissolve • The centrioles divide and begin to migrate to opposite sides of the cell
  • 12. • Centrioles have moved to opposite sides of the cell • The spindle has formed • Chromosomes are lined up in the middle of the cell across the equator
  • 13. • The centromeres split and the spindles pull the sister chromatids apart toward opposite sides of the cell
  • 14. • The chromosomes move to opposite sides of the cell. • The nuclear envelope begins to reform around each set of chromosomes at opposite sides of the cell.
  • 15. • Division of the cytoplasm • Begins to occur during telophase • Different in plants and animal cells
  • 18.  Only occurs in sexually reproducing organisms  The goal of Meiosis is to produce gametes  2 cell divisions result in 4 daughter cells  The chromosome number is halved  Meiosis increases variability as no 2 gametes are the same  Involves two successive divisions  Meiosis I  Meiosis 2
  • 21.  Crossing over consists of a mutual exchange of equal quantity (segments) of chromosomal material between two non-sister chromatids.
  • 23.  Adjacent plasma membrane are closely opposed. intercellular space narrows upto 2-3 nm.  Gap junctions are made up of large protein units called CONNEXONS
  • 24.  "Zonula“ means band  "occludens" = that close off the space between the cells.  are the most apical of the junctions  Seal cells of an epithelial sheet to create a permeability barrier (MCQ)
  • 25.  This junctional type resembles a single "spot-weld" and does not form a belt around the cell  Cadherins: transmembrane proteins.  Bind intermediate filaments rather than actin filaments
  • 26.  Adhere epithelial cells to the basal membrane  Integrins are the transmembrane proteins.  Anchor proteins link integrins to intermediate filaments
  • 27. 1. Alberts, Bruce, “Molecular Biology Of Cell”, 4th Edition, Garland Science, 2008. 2. Lodish, Harvey etal., “Molecular Cell Biology”, 6th Edition, W.H.Freeman, 2008. 3. Dr. Liz Williams, “The Journal Of Cell Biology”, Volume 194, No. 3, August 8,2011. 4. Kara Rogers, “The Cell”, 1st Edition, Britannica, 2011.
  • 28. Submitted to Dr.P.Dhasarathan Ph.D, Senior Assistant Professor, Department Of BioTechnology, PITAM.