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Cells are the Structural and Functional
         Units of an Organism
Cell structure and function
Cells are Diverse in Size, Shape,
           and Length
Parts of a Cell: Nucleus, Cytoplasm, and Plasma Membrane
The Cytoplasm

The major functional area of the cell.


Consists of:

  Cytosol

  Organelles

  Inclusions
Inclusions: Stored Nutrients



                          Glycogen




Lipid (brown fat)
Melanin          Secretory Granules




Substantia Nigra       Pancreas
Mitochondria - Structure
Mitochondria


The site of ATP production.

Metabolically active cells have more mitochondria.

Are self-replicating.

May have evolved from purple bacteria.
Ribosomes


Composed of protein and rRNA.

May be free in the cytoplasm or bound to
endoplasmic reticulum.
Rough Endoplasmic Reticulum
Endoplasmic Reticulum
Smooth Endoplasmic Reticulum
The Golgi Apparatus
The Golgi Apparatus




     Plasma Cells
Lysosomes

Sites of digestion.

Lysosomal enzymes are produced by the RER.

The lysosomal membrane has special adaptations.

Lysosomes function in:

     1. Digestion of ingested particles
     2. Digestion of worn-out organelles
     3. Metabolism of stored glycogen

Lysosomal rupture results in autolysis.
Lysosomes   Phagocytosis
Peroxisomes

Convert free radicals to H2O2

Required for detoxification

Self-replicate
Peroxisomes
The Cytoskeleton
Cytoskeletal Elements




Microtubules:

       * Hollow tubes formed by proteins called tubulins

       * Comprise the centrosome and other structures (e.g., cilia &
         flagella)

       * Variable stability (mitotic spindle is labile)

       * Maintain cell shape and rigidity
Structure of a Microtubule
Cilia




Basal bodies control the assembly of the
axoneme.
Structure of Cilia




Axoneme
Cytoskeletal Elements

Microfilaments:

     consist of thin strands of actin

     form the core of microvilli, allow amoeboid
     movement, produce the cleavage furrow

     most highly developed in muscle cells

     labile

     are attached to the cytoplasmic side of the
     plasma membrane
Cytoskeletal Elements


Intermediate Filaments:

     Intermediate in size

     Have tensile strength

     Most stable

     Specific names in certain cell types
     (see table 2-4)
The Nucleus

The largest organelle and has 3 regions:

    nuclear membrane

    nucleolus – protein and rRNA

    chromatin – DNA and histone proteins
         euchromatin - active
         (vesiculate nucleus)

         heterochromatin - inactive
         (pachychromatic nucleus)
The Nucleus
Nuclear Pores




200,000 X                   48,000 X
Nucleosomes – the fundamental units of chromatin
Intracellular Pigments

* Endogenous or exogenous (environmental)

* Exogenous pigments include carbon and other
  dusts

* Endogenous pigments: lipofuscin, melanin,
  hemosiderin.

     Apoferritin + iron = ferritin

     hemosiderin = large amounts of ferritin
Endogenous Intracellualr Pigments - Hemosiderin
Exogenous Intracellular Pigments



                        Silicosis




                        Asbestosis
Endogenous Intracellular Pigments




          Lipofucsin

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