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Chapter 5
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Ch. 5 integumentary system - part 3
 Affects 1 in 5 Americans
 Caused by UV damage to DNA
Types:
1. Basal cell carcinoma
 Least malignant, most common (80% skin cancers)
 Stratum basale
 Sun-exposed areas of face
 Shiny, dome-shaped nodules
 Slow-growing; rarely metastasizes (spreads)
 Removal by surgery (99% cases)
2. Squamous cell carcinoma
 2nd
most common
 Keratinocytes of stratum spinosum
 Scaly, reddened bump
 Grows rapidly and can metastasize if not removed
 Removal by surgery or radiation therapy
3. Melanoma
 Most dangerous
 Highly metastatic, resistant to chemotherapy
 1/3 from moles (spreading brownblack patch)
 Key = Early detection!!!
 Surgery + immunotherapy
 A = Asymmetry: 2 sides of
pigmented spot do not match
 B = Border irregularity: blurry
or jagged edges
 C = Color: several colors
(brown, black, tan, blue, red)
 D = Diameter: >6mm in
diameter (pencil eraser)
 E = Elevation: raised above
surface or uneven surface
Ch. 5 integumentary system - part 3
 Tissue damage caused by heat, electricity, radiation,
chemicals
 Main threat: loss of fluids (dehydration, electrolyte
imbalance)
Kidney failure, circulatory shock
 Treatment: replace fluids via IV
 Rule of NinesRule of Nines: estimating extent of burns
Divide body into 11 areas
Each part is 9% of total body area + 1% genital region
Ch. 5 integumentary system - part 3
 11stst
-degree burns-degree burns: only epidermis damaged 
swelling, redness, pain (sunburn)
 22ndnd
-degree burns-degree burns: injure epidermis & upper dermis
 redness and pain; blisters
 33rdrd
-degree burns-degree burns: entire thickness of skin, destroy
nerve endings (no pain)  need skin graftskin graft
Ch. 5 integumentary system - part 3
Ch. 5 integumentary system - part 3
Ch. 5 integumentary system - part 3
Ch. 5 integumentary system - part 3
 >25% of body with 2nd
degree burns
 >10% of body with 3rd
degree burns
 3rd
degree burns on face, hands, feet
 Face: swelling of respiratory passages 
suffocation
 Joints: scar tissue formation limits mobility
Ch. 5 integumentary system - part 3
 Fetus: downy coat of colorless hairs (lanugo)
 At birth:
covered with white, cheesy substance (vernix
caseosa) to protect skin in watery environment
Milia: white spots, accumulations in sebaceous
glands (baby acne)
 Childhood: skin thickens; deposit subcutaneous fat
 Adolescence: sebaceous glands activated (oilier hair
and skin), acne appears
 Adults:
Environmental assaults (sun, wind, chemicals)
 Old age: thin skin, less oil (dry skin), less fat, less
elasticity, less hair (greying and balding)
Ch. 5 integumentary system - part 3

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Ch. 5 integumentary system - part 3

  • 3.  Affects 1 in 5 Americans  Caused by UV damage to DNA Types: 1. Basal cell carcinoma  Least malignant, most common (80% skin cancers)  Stratum basale  Sun-exposed areas of face  Shiny, dome-shaped nodules  Slow-growing; rarely metastasizes (spreads)  Removal by surgery (99% cases)
  • 4. 2. Squamous cell carcinoma  2nd most common  Keratinocytes of stratum spinosum  Scaly, reddened bump  Grows rapidly and can metastasize if not removed  Removal by surgery or radiation therapy
  • 5. 3. Melanoma  Most dangerous  Highly metastatic, resistant to chemotherapy  1/3 from moles (spreading brownblack patch)  Key = Early detection!!!  Surgery + immunotherapy
  • 6.  A = Asymmetry: 2 sides of pigmented spot do not match  B = Border irregularity: blurry or jagged edges  C = Color: several colors (brown, black, tan, blue, red)  D = Diameter: >6mm in diameter (pencil eraser)  E = Elevation: raised above surface or uneven surface
  • 8.  Tissue damage caused by heat, electricity, radiation, chemicals  Main threat: loss of fluids (dehydration, electrolyte imbalance) Kidney failure, circulatory shock  Treatment: replace fluids via IV  Rule of NinesRule of Nines: estimating extent of burns Divide body into 11 areas Each part is 9% of total body area + 1% genital region
  • 10.  11stst -degree burns-degree burns: only epidermis damaged  swelling, redness, pain (sunburn)  22ndnd -degree burns-degree burns: injure epidermis & upper dermis  redness and pain; blisters  33rdrd -degree burns-degree burns: entire thickness of skin, destroy nerve endings (no pain)  need skin graftskin graft
  • 15.  >25% of body with 2nd degree burns  >10% of body with 3rd degree burns  3rd degree burns on face, hands, feet  Face: swelling of respiratory passages  suffocation  Joints: scar tissue formation limits mobility
  • 17.  Fetus: downy coat of colorless hairs (lanugo)  At birth: covered with white, cheesy substance (vernix caseosa) to protect skin in watery environment Milia: white spots, accumulations in sebaceous glands (baby acne)
  • 18.  Childhood: skin thickens; deposit subcutaneous fat  Adolescence: sebaceous glands activated (oilier hair and skin), acne appears
  • 19.  Adults: Environmental assaults (sun, wind, chemicals)  Old age: thin skin, less oil (dry skin), less fat, less elasticity, less hair (greying and balding)