The RIS3 Workbook for Learning-Driven Regional Development outlines practical strategies for project organizations, regions, and consortia to meet the EU's smart specialization requirements for 2014-2020. It emphasizes the importance of collaborative leadership, the formation of activity portfolios around shared themes, and leveraging international and domestic funding synergistically. The workbook includes case examples and guidance on orchestrating regional development through experimentation and co-creation in dynamic environments.