The document discusses how European powers explored eastward in the Age of Exploration to find a direct sea route to Asia for trade opportunities and profits. Portugal was first to venture into the Atlantic, proving Africa could be sailed around. Spain joined Portugal's efforts under Ferdinand and Isabella, with Columbus landing in the Caribbean thinking he reached India. Magellan proved in 1522 that the world was round and larger than thought, and no feasible trade route existed west. Portugal focused on trade over colonization, dominating Africa and India. Spain sought wealth and conversion to Christianity, conquering Aztec and Inca civilizations and controlling America and West Indies by 1600. Disease and mistreatment reduced native populations, replaced by African slaves.