This chapter discusses drug use in contemporary society. It notes that nearly every American has used a mind-altering substance such as alcohol, cigarettes, or caffeine. It provides statistics on drug use from national surveys. It discusses the health, social, and economic costs of drug use as well as patterns of drug taking and the extent of drug use according to national surveys. It also covers topics like drug use and education/employment outcomes, drug testing policies, and the large illegal drug business.