The document summarizes major figures and developments in Renaissance and Mannerism in Italy. It discusses how the Medici family, led by Giovanni de' Medici and his son Cosimo, made Florence the cultural center of Renaissance Europe through their patronage of the arts. Individual genius was allowed to flourish during the Renaissance in Italy. Key Renaissance artists mentioned include Leonardo da Vinci, Raphael, and Michelangelo. The document also identifies Josquin Des Pres as the musical composer most closely associated with the High Renaissance.