The document provides a comprehensive overview of the historical development of Rasa Shastra, a crucial branch of Ayurveda focusing on alchemy and the use of minerals in medicinal practices. It traces the origins of Rasa Shastra from the pre-Vedic period, highlighting significant advancements during the time of Lord Buddha and the philosophical influences thereafter, ultimately recognizing it as an independent medical science by the 14th century. The document also discusses various classical texts and contributors to Rasa Shastra, emphasizing its therapeutic applications and the evolution of methodologies for the use of metals and minerals in health care.