This document provides guidelines for organizations to prevent and respond to ransomware attacks. It recommends joining an information sharing organization and engaging with CISA to receive critical threat information and services. The document includes best practices for ransomware prevention, such as regularly backing up data offline, maintaining system images, patching software, securing remote access, and conducting phishing awareness training. It also provides tips to address infection vectors like internet-facing vulnerabilities, phishing emails, and precursor malware infections.