Classification of Solubility Enhancement Techniques
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This document defines solubility and discusses the need for enhancing solubility of poorly soluble drugs. It classifies techniques for enhancing drug solubility into chemical modifications, physical modifications, and other approaches such as pH adjustment and use of supercritical fluids. Chemical modifications include techniques like salt formation, co-crystallization, and use of novel solubilizers. Physical modifications involve methods for reducing particle size, modifying crystal habits, and using surfactants, solid solutions, and inclusion complexes to improve solubility. Proper solubility is essential for drug absorption and bioavailability after oral administration.
Classification of Solubility Enhancement Techniques
- 1. PREPARED BY : Mr. Santu S. Mistree M-Pharm (P’ceutics) P.Wadhwani college of Pharmacy Yavatmal (MH)
- 2. CONTENT’S Definition of Solubility Need of Solubility Classification of Solubility Enhancement Technique’s References
- 3. Definition of solubility.. In quantitative terms, it may be defined as the concentration of the solute in a saturated solution at a certain temperature. OR In qualitative terms, the spontaneous interaction of two or more substances to form a homogeneous molecular dispersion. The solubility may be expressed as parts, percentage, molarity, molality, volume fraction, and mole fraction.
- 4. Need of solubility… Drug absorption from the GIT is a most important process for getting therapeutic effect BUT Its limited by various factors like poor aqueous solubility and permeability of drug molecules. After orall administration of drug, it first dissolved in GI fluids or intestinal fluids, prior to permeation through GI membrane in order to reach systemic circulation. Therefore, to enhance bioavailabilty of active agents, the p’ceutical researcher focus on two area include enhancing solubility and dissolution rate of poorly water soluble drugs.
- 5. Classification of Solubility Enhancement Techniques.. The solubility enhancement technique are classified as per following way, A) Chemical Modifications: Salt Formation Co-crystallization Co-solvency Hydrotropy Use of novel solubilizer Nanotechnology
- 6. B) Physical Modifications: B-1) Particle size reduction: Conventional method Micronization Nanosuspension B-2) Modification of the crystal habit: Polymorphs Pseudo polymorphs B-3) Complexation: Physical mixture Kneading method Co-precipitate method
- 7. B-4) Inclusion Complex Formulation Based Techniques: Kneading method Lyophilization/ Freeze- drying Technique Microwave irradiation method B-5) Solubilization by surfactants: Micro emulsions Self-micro emulsifying drug delivery system B-6) Drug dispersion in carriers: B-6-a) Solid solutions: Fusion Process Solvent Method
- 8. Solvent Method Fusion solvent method Spray drying Lyophilization Hot melt Extrusion Dropping Method C) PH Adjustment D) Supercritical Fluid Process E) Liquisolid Technique F) Polymeric Alterssation
- 9. References.. 1. Limbachiya M.I, Solubility enhancement techniques for poorly soluble drugs: A review. IJPRD, 2011;4(4): 71-86 2. Patil MS, Godse SG, Saudagar RB. Solubility Enhancement by Various Techniques: An overview. World journal of pharmacy and pharmaceutical sciences. 2013; 2(6):4558-4572. 3. Kadam SV, Shinkar DM, Saudagar RB., Int.j.pharm.biol.sci. 2015,3 (3), 462-475.
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