This document summarizes research on measuring the impact of mission-driven organizations like NASA. It discusses challenges in quantifying new knowledge generated by research and how it benefits stakeholders. The document outlines NASA's goals for the International Space Station regarding scientific, technological and educational purposes. It also provides statistics on the breadth of scientific disciplines studied on the ISS and growth in citations to this research, demonstrating diffusion of knowledge within space journals and more broadly. In conclusion, it acknowledges key contributors and states that a "science of science" approach can objectively describe ISS science outputs and impacts.