This proposal submission from clinicalMessage responds to the Matchmaking Innovation request to help connect patients and researchers differently. The clinicalMessage platform can engage providers, patients, and researchers to collaboratively develop research questions, share data according to consent, and disseminate results to improve population health outcomes. clinicalMessage currently provides capabilities for patient engagement, provider decision support, and outcomes registries. Partnering with Matchmaking could help clinicalMessage expand these capabilities to more populations and research areas. The proposal demonstrates how clinicalMessage meets the criteria of connecting diverse groups, developing usable models, and maximizing patient-centeredness while ensuring scientific rigor in potential collaborations.