This document provides an overview of cloud computing models and their application in healthcare. It defines cloud computing, outlines the service models of infrastructure as a service (IaaS), platform as a service (PaaS), and software as a service (SaaS). It also discusses deployment models and roles. The document reviews benefits of cloud computing for healthcare organizations, as well as challenges regarding control, security and legal issues when moving healthcare data to the cloud. It profiles real-world case studies of cloud computing for diabetes management in Chile and current cloud adoption within a large Spanish regional health agency.