This document discusses collaboration between science and industry for innovation. It presents different sources of innovation, both internal and external. It also classifies innovations as incremental, radical, new to the company, or new to the world. The document addresses the challenges of collaboration between policy, science, and industry, known as the "triple helix." It analyzes how setting the right framework conditions through funding programs can encourage cooperation. Examples of successful collaborative R&D programs between academia and industry in Germany are provided. The document concludes that the program design is key to stimulating cooperation and provides recommendations.