Common laboratory animals part 2
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Common laboratory animals used in drug development include rodents like mice and rats as well as non-rodents. Non-rodent models discussed in the document include rabbits, monkeys, cats, dogs, frogs, zebrafish, chickens, and pigeons. Rabbits are used for pyrogen testing due to their resistance to atropine. Monkeys such as rhesus monkeys and squirrel monkeys are used due to their similarity to humans, though squirrel monkeys are smaller making them easier to handle. Cats and dogs are also used for research due to their similarities to humans. Frogs have provided a new class of antibiotic compounds and zebrafish are used for genetic research due to external fertilization. Chick
Common laboratory animals part 2
- 1. Common laboratory animals used in Drug Development Part- II Dr. K. Manohar Babu VJ’s College of Pharmacy Rajamahendravaram
- 2. Contents Types of animal models Non Rodent Animal Models Rabbit Monkey Cat Dog Miscellaneous Frog Zebra Fish Chicken Pigeon
- 3. INTRODUCTION Physiologically and Anatomically there is a similarity between the humans and animals at organs and organ systems, which function in a similar fashion. This similarity makes animals ideal models for the study and development of products and techniques for humans.
- 4. Animals used in Research Mammals Rodents Non Rodents Miscellaneous Mice, Rat, Guinea pig, Hamsters Rabbit, Dog, Cat, Monkey Pigeon, Zebra fish, Chicken
- 6. Non Rodents Animals Rabbit Monkey Cat Dog
- 7. Rabbits (Oryctolagus cuniculus) Domestic rabbits (2-3kg) are used for pyrogen testing. one of the peculiar thing about rabbits is that they are resistant to the action of atropine as they contain atropinesterase enzyme, the presence of which is genetically determined. Some of the tissue or organs from rabbits used are heart, aorta, duodenum and ileum.
- 8. Gestation : 30-33 days Parturition = Kindling Weaning : 4-6 weeks Offspring NZW : 8-10 kits Dutch : 5-6 kits Ovulation : Coitus Induced Estrus : Continuous Lifespan NZW : 5-6+ years Dutch : 5-10+ years
- 9. Use of Rabbit in Research Development of Rabis vaccine Bio assay of Diabetes drugs Hypertension Glaucoma Eye and ear infection Testing of Anti fertility agents Testing of cosmetics using Draize test
- 11. Rhesus monkey
- 12. Squirrel monkey • Squirrel monkeys are small in size and ease of handling that contribute to their desirability as research subjects. • The mean body weight of adult squirrel monkeys is less than 1 kg compared with female rhesus monkeys, which usually weigh 4 – 5 kg. • Smaller doses necessary sp. Expensive medications • easily adapt to laboratory housing
- 15. Miscellaneous Animals Frog Zebra Fish Chicken Pigeon
- 16. FROG (Rana tigrine) New class of antibiotic compounds in frog skin called magainins .
- 17. ZEBRA FISH (Danio reiro)