Client-side languages like HTML, CSS, and JavaScript are used to build the front-end structure, layout, and interactive behavior of webpages. Server-side languages like PHP are used to dynamically output content from a server like HTML, images, and files. Each language has a specific purpose, with HTML defining content structure, CSS specifying design, JavaScript programming behavior, and PHP processing server-side code. They each allow different abilities ranging from basic webpage structure to dynamic content generation and processing.