Complement pathway (mnemonic)
- 1. COMPLEMENT SYSTEM MNEMONICS Ms. A. INDUMATHI & M.V.MALA PG & RESEARCH DEPARTMENT OF BIOTECHNOLOGY Bon Secours College for Women, Thanjavur IMMUNOLOGY
- 2. ❑ INTRODUCTION ❑ COMPLEMENT COMPONENT Classical Alternative Mannose Binding Lectin Pathway Pathway Pathway ❑ BIOLOGIC EFFECTS ❑ REGULATION ❑ CONCLUSION
- 3. COMPLEMENT COMPONENTS • Complement was discoverd by Jules Bordet as a heat- labile component of normal plasma that causes the Opsonisation and killing of bacteria. • Group of 20 plasma proteins and essential part in the innate immunity. • Word “Complement” enhances or complements our immunity • 11 protein are mostly involved name as B, C1-C9 and D.
- 4. Catalyze a series of enzymatic reactions Products of complement system ENZYMES CASCADE the activations of one protein to another protein with enzyme help • Attracts macrophagess and neutrophils and also actives mast cell.
- 5. Activation of Complement System
- 6. Classical Pathway • This pathway involves complement components C1, C2, C4. • This pathway is triggered by antibody -antigen complex binding to C1. • Three subcomponents C1q, C1r and C1s. • It produce C3 with help of cnvertase hydeolysis subcomplement component C3a small and C3b large fragment.
- 7. Alternative Pathway • This pathway involves various factors B,D,H.and I • This inhibited by molecules on the surface of normal mammalian cells. e.g., bacterial lipopolysaccharides (endotoxin), fungal cell well , and viral envelopes. • Usually activated by products of micro organisms like endotoxin. • One of first responds of innate immune system.
- 8. Lytic Pathway • This pathway is initiated by the splitting of C5, and attachment of C5b to a target. • C6,C7,C8 and C9 unite with C5b. this membrane attack complex (MAC). • C5 C5b C6 MAC C7 C8 Lysis the bacteria C9
- 9. Review
- 11. ➢ OPSONIZATION • C3b &C1q -enhance phagocytosis
- 12. ➢ Anaphylatoxin ( C3a,C4a,C5a ) • Smaller complement fragments ➢ Cytolysis (MAC) • Disrupt the mambrane and entry H2O and electrolyte into the cell.
- 13. ➢ Enhancement of antibody production • Binding of C3b its receptors on the surface of activated B cells enhanced antibody production. ROLE OF COMPLEMENT IN DISEASE ▪ This inflammation Response ▪ Fungal infection ▪ Bacterial infection
- 15. REGULATION C1 Inhibitor • Important regulator of classic pathway Factor H • Regulate alternative pathway Properdin • Protects C3b and stabilizes C3 convertase Complement receptor Complement protein
- 18. CONCLUSION • The complement system is a group of serum protein, which participate in innate as well as adaptive immune response. • The complement system is characteristically activated by antigen antibody interaction. • It is help antibacterial cells and molecules of the immune system.
- 19. THANK YOU
- 20. mnemonic • CP- 142 • LP- 42 • AP- C3,b,D,B,P C3 Rest is same