Tally ERP9 provides comprehensive support for GST compliance in India. Key aspects include activating GST in Tally, setting up GST at the company, ledger, and inventory levels, and understanding GST taxes like SGST, CGST, and IGST. Transactions can be recorded using purchase and sales vouchers with GST details. GST reports and returns like GSTR-1 can be generated to meet regulatory filing requirements.