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Continued Rebound:
Trends in Life Science M&A
Silicon Valley Bank
July 2012




Written By:
         y
Jonathan Norris
Managing Director
650.926.0126
jnorris@svb.com



                             1
Agenda   • Part I:Overview of 2011 Big Exits
         • Part II: Analysis by Indication
             o Series A Investment by Indication
               between 2005 and 2011
             o LPI and Hit Rate – Measuring
               Indication Performance in the Life
               Science Industry




                                                    2
Overview of Big Exits




                        3
M&A Big Exits Per Year (
      g                (2005-2011)
                                 )




                                     4
Total Big Exit Dollar Volume
        g




                               5
Average Time to Exit
     g




                       6
Biotech Deal Type
              yp




                    7
Biotech Big Exits
          g




                    8
Biotech Structured Deal Breakdown




                                    9
Biotech Breakdown by Stage, Round, Years to Exit
                   y    g ,      ,




                                               10
Biotech Upfront Payments by Stage in Structured
Deal Era (2009-2011)
         (         )




                                                  11
Device Big Exits
         g




                   12
Device Structured Deal Breakdown




                                   13
Device Stage Breakdown
          g




                         14
Device Capital Efficient Exits by Multiple
         p                      y      p




                                             15
Analysis By Indication
    y     y




                         16
Life Science Series A Data




                             17
Biotech Series A Data




                        18
Device Series A Data




                       19
Life Science Investments by Indication
                          y




                                         20
Indication Breakdown: Biotech




                                21
Indication Breakdown: Med Device




                                   22
Biotech Indication Performance Data




                                      23
Device Indication Performance Data




                                     24
Disclosures

 This material, including without limitation the statistical information herein, is provided for
 informational purposes only. The material is based in part upon information from third-party
                          only
 sources that we believe to be reliable, but which has not been independently verified by us
 and, as such, we do not represent that the information is accurate or complete. The
 information should not be viewed as tax, investment, legal or other advice nor is it to be
 relied on in making an investment or other decision. You should obtain relevant and specific
 professional advice b f
     f   i    l d i before making any i
                                ki         investment d i i
                                                t     t decision. N thi relating t th material
                                                                   Nothing l ti to the        t i l
 should be construed as a solicitation or offer, or recommendation, to acquire or dispose of
 any investment or to engage in any other transaction.
 U.S. VC-backed Service companies were included under the device category. Services
 represented l
          t d less th 10 percent of all d l i thi category. R ti
                   than           t f ll deals in this t        Rational f i l di
                                                                       l for including
 Services was to try and capture as much U.S. LS Venture investment as possible -
 creating an additional category with a small data set did not make sense.

 ©2012 SVB Financial Group All rights reserved Member Federal Reserve System
                     Group.           reserved.                         System.
 SVB>, SVB>Find a way, SVB Financial Group, and Silicon Valley Bank are registered
 trademarks. B-12-12265. Rev. 07-16-12.




                                                                                                  25
Continued Rebound: Trends in Life Science M&A

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Continued Rebound: Trends in Life Science M&A

  • 1. Continued Rebound: Trends in Life Science M&A Silicon Valley Bank July 2012 Written By: y Jonathan Norris Managing Director 650.926.0126 jnorris@svb.com 1
  • 2. Agenda • Part I:Overview of 2011 Big Exits • Part II: Analysis by Indication o Series A Investment by Indication between 2005 and 2011 o LPI and Hit Rate – Measuring Indication Performance in the Life Science Industry 2
  • 3. Overview of Big Exits 3
  • 4. M&A Big Exits Per Year ( g (2005-2011) ) 4
  • 5. Total Big Exit Dollar Volume g 5
  • 6. Average Time to Exit g 6
  • 10. Biotech Breakdown by Stage, Round, Years to Exit y g , , 10
  • 11. Biotech Upfront Payments by Stage in Structured Deal Era (2009-2011) ( ) 11
  • 13. Device Structured Deal Breakdown 13
  • 15. Device Capital Efficient Exits by Multiple p y p 15
  • 17. Life Science Series A Data 17
  • 18. Biotech Series A Data 18
  • 19. Device Series A Data 19
  • 20. Life Science Investments by Indication y 20
  • 25. Disclosures This material, including without limitation the statistical information herein, is provided for informational purposes only. The material is based in part upon information from third-party only sources that we believe to be reliable, but which has not been independently verified by us and, as such, we do not represent that the information is accurate or complete. The information should not be viewed as tax, investment, legal or other advice nor is it to be relied on in making an investment or other decision. You should obtain relevant and specific professional advice b f f i l d i before making any i ki investment d i i t t decision. N thi relating t th material Nothing l ti to the t i l should be construed as a solicitation or offer, or recommendation, to acquire or dispose of any investment or to engage in any other transaction. U.S. VC-backed Service companies were included under the device category. Services represented l t d less th 10 percent of all d l i thi category. R ti than t f ll deals in this t Rational f i l di l for including Services was to try and capture as much U.S. LS Venture investment as possible - creating an additional category with a small data set did not make sense. ©2012 SVB Financial Group All rights reserved Member Federal Reserve System Group. reserved. System. SVB>, SVB>Find a way, SVB Financial Group, and Silicon Valley Bank are registered trademarks. B-12-12265. Rev. 07-16-12. 25