Sandeep Cashyap discusses cost optimization when using AWS. He emphasizes that AWS allows customers to pay only for what they use. There are many areas where customers can optimize costs, such as rightsizing instances, using reserved instances and spot instances, stopping unused resources, and using different storage classes. Customers should focus on five pillars of cost optimization: right-sizing instances, using the right pricing models, increasing elasticity, monitoring usage, and matching usage to appropriate storage classes.